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These cells have been\nhistorically considered as carrying out a single function in insects, namely the\nbiochemical conversion of cholesterol to ecdysteroids and their secretion. A growing\nbody of evidence shows that PG cells receive multiple cues during insect development\nso we tested the hypothesis that they carry out more than just one function in\ninsects. We characterised the molecular nature and developmental profiles of cell\nmembrane receptors in PG cells of <jats:italic>Bombyx mori<\/jats:italic> during the final larval stage\nand determined what receptors decode nutritional, developmental and physiological\nsignals. Through iterative approaches we identified a complex repertoire of cell\nmembrane receptors that are expressed in intricate patterns and activate previously\nunidentified signal transduction cascades in PG cells. The expression patterns of\nsome of these receptors explain precisely the mechanisms that are known to control\necdysteroidogenesis. However, the presence of receptors for the notch, hedgehog and\nwingless signalling pathways and the expression of innate immunity-related receptors\nsuch as phagocytosis receptors, receptors for microbial ligands and Toll-like\nreceptors call for a re-evaluation of the role these cells play in insects.<\/jats:p>","DOI":"10.1038\/srep20229","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T10:29:35Z","timestamp":1454668175000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Reassessing ecdysteroidogenic cells from the cell membrane receptors\u2019\nperspective"],"prefix":"10.1038","volume":"6","author":[{"given":"Alexandros","family":"Alexandratos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Moulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Nellas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Mavridis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Skarlatos G.","family":"Dedos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,5]]},"reference":[{"key":"BFsrep20229_CR1","doi-asserted-by":"crossref","unstructured":"Smith, W. & Rybczynski, R. 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