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Clinical records of a total of 654 patients with HBoV infection during January 2013 and December 2014 were retrospectively reviewed. Patients with high HBoV virus load infection had a similar age distribution with the total HBoV infection, which had a peak age group of 6\u201324 months. Patients with high virus load are significantly younger (P\u2009&lt;\u20090.01) than those with low load. The patients who had wheeze and tachypnea\/dyspnea at presentation were more strongly affiliated with the patients with high virus load (both P\u2009&lt;\u20090.01). Co-infection was found significantly more frequently among patients with low virus load than those with high virus load (57.0% vs 38.9%; P\u2009&lt;\u20090.01). High virus load was a significant predictor of severe LRTI (P\u2009&lt;\u20090.05). HBoV infections are found in an important proportion of the hospitalized children with respiratory illnesses (8.85% in our series). A high HBoV virus load could be an etiologic agent for LRTI, which may lead to more severe lower respiratory tract symptom and severe disease.<\/jats:p>","DOI":"10.1038\/srep20246","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T09:53:47Z","timestamp":1454320427000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Clinical significance of different virus load of human bocavirus in patients with lower respiratory tract infection"],"prefix":"10.1038","volume":"6","author":[{"given":"Wujun","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongdong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,1]]},"reference":[{"key":"BFsrep20246_CR1","doi-asserted-by":"publisher","first-page":"12891","DOI":"10.1073\/pnas.0504666102","volume":"102","author":"T Allander","year":"2005","unstructured":"Allander, T. et al. 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