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We investigated the relationship between SVD, multiple isoforms of A\u03b2 in cerebrospinal fluid (CSF) and cortical A\u03b2 in 831 subjects with cognitive performance ranging from normal to Alzheimer\u2019s disease (AD) (the Swedish BioFINDER study). SVD was estimated as white matter lesions (WML) and lacunes. 18F-flutemetamol PET was performed in 321 subjects. Lower CSF levels of A\u03b238 and A\u03b240 were consistently associated with increased WML in all subgroups, while lower levels of CSF A\u03b242 were associated with WML mainly in AD. CSF A\u03b238 and A\u03b240 were associated with regional WML in all regions, while CSF A\u03b242 was associated with temporal WML only. A composite measure of 18F-flutemetamol uptake was not associated with WML, and regional 18F-flutemetamol uptake only with temporal WML. Lacunes were not associated with A\u03b2 isoforms nor 18F-flutemetamol uptake. Our results suggest that WML may be associated with alterations in the production or clearance of A\u03b2 species, particularly of A\u03b238 and A\u03b240. However, in AD cases, A\u03b242 pathology might be associated with WML, especially in the temporal lobe.<\/jats:p>","DOI":"10.1038\/srep20709","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T10:20:18Z","timestamp":1455013218000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Cerebral white matter lesions \u2013 associations with A\u03b2 isoforms and amyloid PET"],"prefix":"10.1038","volume":"6","author":[{"given":"Danielle","family":"van Westen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Lindqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Minthon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarina","family":"N\u00e4gga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Stomrud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oskar","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,9]]},"reference":[{"key":"BFsrep20709_CR1","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","volume":"9","author":"L Pantoni","year":"2010","unstructured":"Pantoni, L. 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