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In this study, we thoroughly assess whether MICA-TM gene variants are associated with BD by means of a systematic review and meta-analysis. Our study focused on the effects of polymorphisms of MICA-A4, A5, A5.1, A6 and A9 from the included articles. Sixteen previous original publications representing 1,555 BD patients and 2,086 unrelated healthy controls analyzed the association of BD with MICA-TM gene polymorphisms. For the five alleles, MICA-A6 showed a strongly positive correlation with BD patients and could be viewed as an increased risk factor of BD (OR\u2009=\u20092.34, 95%CI: 2.02\u20132.70). Furthermore, MICA-A4, A5, A5.1 and A9 exhibited negative associations with BD (OR\u2009=\u20090.71, 95%CI: 0.58\u20130.86; OR\u2009=\u20090.75, 95%CI: 0.63\u20130.90; OR\u2009=\u20090.63, 95%CI: 0.44\u20130.91; OR\u2009=\u20090.70, 95%CI: 0.58\u20130.84, respectively). Our meta-analysis confirmed MICA-A6 could be responsible for BD in three ethnic regions and should probably be treated as a risk factor for BD. MICA-A4, A5, A5.1 and A9 could be regarded as protective factors, especially in the Middle East and East Asia.<\/jats:p>","DOI":"10.1038\/srep21033","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T10:37:18Z","timestamp":1455532638000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association between Functional MICA-TM and Behcet\u2019s Disease: A Systematic Review and Meta-analysis"],"prefix":"10.1038","volume":"6","author":[{"given":"Jun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengping","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,15]]},"reference":[{"key":"BFsrep21033_CR1","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1073\/pnas.94.4.1298","volume":"94","author":"N Mizuki","year":"1997","unstructured":"Mizuki, N. et al. 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