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It was investigated whether measurement of basal pulmonary artery pressure (Ppa) and brain natriuretic peptide (BNP) could improve identification of HAPE susceptible subjects in a non-mountaineer population. We studied BNP levels, baseline hemodynamics and the response to hypoxia (FIo<jats:sub>2<\/jats:sub>\u2009=\u20090.12 for 30\u2009min duration at sea level) in 11 HAPE resistant (no past history of HAPE, Control) and 11 HAPE susceptible (past history of HAPE, HAPE-S) subjects. Baseline Ppa (19.31\u2009\u00b1\u20093.63 vs 15.68\u2009\u00b1\u20092.79\u2009mm Hg, p\u2009&lt;\u20090.05) and plasma BNP levels (52.39\u2009\u00b1\u200932.9 vs 15.05\u2009\u00b1\u20099.6\u2009pg\/ml, p\u2009&lt;\u20090.05) were high and stroke volume was less (p\u2009&lt;\u20090.05) in HAPE-S subjects compared to control. Acute hypoxia produced an exaggerated increase in heart rate (p\u2009&lt;\u20090.05), mean arterial pressure (p\u2009&lt;\u20090.05) and Ppa (28.2\u2009\u00b1\u20095.8 vs 19.33\u2009\u00b1\u20093.74\u2009mm Hg, p\u2009&lt;\u20090.05) and fall in peripheral oxygen saturation (p\u2009&lt;\u20090.05) in HAPE-S compared to control. Receiver operating characteristic (ROC) curves showed that Ppa response to acute hypoxia was the best variable to identify HAPE susceptibility (AUC 0.92) but BNP levels provided comparable information (AUC 0.85). BNP levels are easy to determine and may represent an important marker for the determination of HAPE susceptibility.<\/jats:p>","DOI":"10.1038\/srep21357","type":"journal-article","created":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T10:24:52Z","timestamp":1455877492000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Elevated pulmonary artery pressure and brain natriuretic peptide in high altitude pulmonary edema susceptible non-mountaineers"],"prefix":"10.1038","volume":"6","author":[{"given":"Rajinder K.","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Himashree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishan","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Soree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koundinya","family":"Desiraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dishari","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Dass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prassana K.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha","family":"Panjwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashi Bala","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"key":"BFsrep21357_CR1","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1002\/cphy.c100029","volume":"2","author":"ER Swenson","year":"2012","unstructured":"Swenson, E. 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