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Male C57BL\/6 mice were randomly assigned into three groups (n\u2009=\u20096): sham, intestinal I\/R + vehicle, and intestinal I\/R + fenofibrate. Intestinal I\/R was achieved by clamping the superior mesenteric artery. Fenofibrate (100\u2009mg\/kg) or equal volume of vehicle was injected intraperitoneally 60\u2009minutes before the ischemia. At the end of experiment, measurement of pathohistological score, inflammatory mediators and other markers were performed. In addition, a 24-hour survival experiment was conducted in intestinal I\/R mice treated with fenofibrate or vehicle. The chief results were as anticipated. Pathohistological evaluation indicated that fenofibrate ameliorated the local intestine damage and distant lung injury. Pretreatment with fenofibrate significantly decreased inflammatory factors in both the intestine and the lung. Consistently, renal creatine levels and hepatic ALT levels were significantly decreased in the fenofibrate group. Moreover, serum systemic inflammatory response indicators were significantly alleviated in the fenofibrate group. In addition, fenofibrate administration significantly improved the survival rate. 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