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Infiltration and\/or migration of macrophages into the infarct area early after MI is critical for infarct healing, vascularization and cardiac function. Hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) has been demonstrated to possess cardioprotective effects post MI and during the progress of cardiac remodeling. However, the specific molecular and cellular mechanisms involved in macrophage recruitment by H\n                    <jats:sub>2<\/jats:sub>\n                    S remain to be identified. In this study, the NaHS (exogenous sources of H\n                    <jats:sub>2<\/jats:sub>\n                    S) treatment exerted an increased infiltration of macrophages into the infarcted myocardium at early stage of MI cardiac tissues in both wild type (WT) and cystathionine-\u03b3-lyase-knockout (CSE-KO) mice. And NaHS accelerated the migration of macrophage cells\n                    <jats:italic>in vitro<\/jats:italic>\n                    . While, the inhibitors not only significantly diminished the migratory ability in response to NaHS, but also blocked the activation of phospho-Src, -Pyk2, -FAK\n                    <jats:sup>397<\/jats:sup>\n                    and -FAK\n                    <jats:sup>925<\/jats:sup>\n                    . Furthermore, NaHS induced the internalization of integrin \u03b21 on macrophage surface, but, integrin \u03b21 silencing inhibited macrophage migration and Src signaling activation. These results indicate that H\n                    <jats:sub>2<\/jats:sub>\n                    S may have the potential as an anti-infarct of MI by governing macrophage migration, which was achieved by accelerating internalization of integrin \u03b21 and activating downstream Src-FAK\/Pyk2-Rac pathway.\n                  <\/jats:p>","DOI":"10.1038\/srep22363","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T06:11:50Z","timestamp":1456899110000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Hydrogen Sulfide Recruits Macrophage Migration by Integrin \u03b21-Src-FAK\/Pyk2-Rac Pathway in Myocardial Infarction"],"prefix":"10.1038","volume":"6","author":[{"given":"Lei","family":"Miao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Zhun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"BFsrep22363_CR1","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1253\/circj.CJ-09-0338","volume":"73","author":"JM Downey","year":"2009","unstructured":"Downey, J. 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