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Human parathyroid hormone (PTH), a member of class B GPCRs, binds to its receptor <jats:italic>via<\/jats:italic> its N\u2013terminal domain, thereby activating the pathway to this secondary messenger inside cells. Presently, GPCRs are the target of many pharmaceuticals however, these drugs target only a small fraction of structurally known GPCRs (about 10%). Coordination complexes are gaining interest due to their wide applications in the medicinal field. In the present studies we explored the potential of a coordination complex of Zn(II) and anthracenyl\u2013terpyridine as a modulator of the parathyroid hormone response. Preferential interactions at the N\u2013terminal domain of the peptide hormone were manifested by suppressed cAMP generation inside the cells. These observations contribute a regulatory component to the current GPCR\u2013cAMP paradigm, where not the receptor itself, but the activating hormone is a target. To our knowledge, this is the first report about a coordination complex modulating GPCR activity at the level of deactivating its agonist. Developing such molecules might help in the control of pathogenic PTH function such as hyperparathyroidism, where control of excess hormonal activity is essentially required.<\/jats:p>","DOI":"10.1038\/srep22533","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T11:12:20Z","timestamp":1456917140000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Small Molecule Inhibited Parathyroid Hormone Mediated cAMP Response by N\u2013Terminal Peptide Binding"],"prefix":"10.1038","volume":"6","author":[{"given":"Amit","family":"Kumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"Balbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,3,2]]},"reference":[{"key":"BFsrep22533_CR1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cbpa.2012.01.013","volume":"16","author":"G Gasser","year":"2012","unstructured":"Gasser, G. & Metzler-Nolte, N. 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