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In the joint environment there are mesenchymal stem\/progenitor cells (MSCs) in the synovial membrane and synovial fluid that can differentiate into cartilage, but it is still under debate if these cells contribute to cartilage repair <jats:italic>in vivo<\/jats:italic>. In this study, we isolated a Sca-1 positive, chondrogenesis capable population of mouse synovial MSCs from C57BL6 and MRL\/MpJ \u201csuper-healer\u201d strains. Intra-articular injection of Sca-1\u2009+\u2009GFP\u2009+\u2009synovial cells from C57BL6 or MRL\/MpJ into C57BL6 mice following cartilage injury led to increased cartilage repair by 4 weeks after injury. GFP expression was detected in the injury site at 2 weeks, but not 4 weeks after injury. These results suggest that synovial stem\/progenitor cells, regardless of strain background, have beneficial effects when injected into an injured joint. MSCs derived from MRL\/MpJ mice did not promote an increased repair capacity compared to MSCs derived from non-healing C57BL6 controls; however, MRL\/MpJ MSCs were observed within the defect area at the time points examined, while C57BL6 MSCs were not.<\/jats:p>","DOI":"10.1038\/srep23076","type":"journal-article","created":{"date-parts":[[2016,3,17]],"date-time":"2016-03-17T11:29:49Z","timestamp":1458214189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Intra-articular injection of synovial mesenchymal stem cells improves cartilage repair in a mouse injury model"],"prefix":"10.1038","volume":"6","author":[{"given":"J.","family":"Mak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. L.","family":"Jablonski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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