{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:11:04Z","timestamp":1790730664121,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>RIG-I is a key cytosolic RNA sensor that mediates innate immune defense against RNA virus. Aberrant RIG-I activity leads to severe pathological states such as autosomal dominant multi-system disorder, inflammatory myophathies and dermatomyositis. Therefore, identification of regulators that ensure efficient defense without harmful immune-pathology is particularly critical to deal with RIG-I-associated diseases. Here, we presented the inflammatory inducible FAT10 as a novel negative regulator of RIG-I-mediated inflammatory response. In various cell lines, FAT10 protein is undetectable unless it is induced by pro-inflammatory cytokines. FAT10 non-covalently associated with the 2CARD domain of RIG-I, and inhibited viral RNA-induced IRF3 and NF-kB activation through modulating the RIG-I protein solubility. We further demonstrated that FAT10 was recruited to RIG-I-TRIM25 to form an inhibitory complex where FAT10 was stabilized by E3 ligase TRIM25. As the result, FAT10 inhibited the antiviral stress granules formation contains RIG-I and sequestered the active RIG-I away from the mitochondria. Our study presented a novel mechanism to dampen RIG-I activity. Highly accumulated FAT10 is observed in various cancers with pro-inflammatory environment, therefore, our finding which uncovered the suppressive effect of the accumulated FAT10 during virus-mediated inflammatory response may also provide molecular clue to understand the carcinogenesis related with infection and inflammation.<\/jats:p>","DOI":"10.1038\/srep23377","type":"journal-article","created":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T09:47:35Z","timestamp":1458553655000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform"],"prefix":"10.1038","volume":"6","author":[{"given":"Nhung T.H.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesung","family":"Now","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Jong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nari","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo-Yeon","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,21]]},"reference":[{"key":"BFsrep23377_CR1","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1038\/ni1087","volume":"5","author":"M Yoneyama","year":"2004","unstructured":"Yoneyama, M. et al. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5, 730\u2013737 (2004).","journal-title":"Nat. Immunol."},{"key":"BFsrep23377_CR2","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nri2975","volume":"11","author":"AP West","year":"2011","unstructured":"West, A. P., Shadel, G. S. & Ghosh, S. Mitochondria in innate immune responses. Nature reviews. Immunol. 11, 389\u2013402 (2011).","journal-title":"Nature reviews. Immunol."},{"key":"BFsrep23377_CR3","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.cell.2005.08.012","volume":"122","author":"RB Seth","year":"2005","unstructured":"Seth, R. B., Sun, L., Ea, C. K. & Chen, Z. J. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669\u2013682 (2005).","journal-title":"Cell"},{"key":"BFsrep23377_CR4","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.immuni.2011.05.003","volume":"34","author":"YM Loo","year":"2011","unstructured":"Loo, Y. M. & Gale, M. Jr. Immune signaling by RIG-I-like receptors. Immunity 34, 680\u2013692 (2011).","journal-title":"Immunity"},{"key":"BFsrep23377_CR5","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1084\/jem.20101664","volume":"207","author":"G Trinchieri","year":"2010","unstructured":"Trinchieri, G. Type I interferon: friend or foe? J. Exp. Med. 207, 2053\u20132063 (2010).","journal-title":"J. Exp. Med."},{"key":"BFsrep23377_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1128\/MMBR.05015-11","volume":"76","author":"JR Tisoncik","year":"2012","unstructured":"Tisoncik, J. R. et al. Into the eye of the cytokine storm. Microbiol. Mol. Biol. Rev. 76, 16\u201332 (2012).","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"BFsrep23377_CR7","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.ajhg.2014.11.019","volume":"96","author":"MA Jang","year":"2015","unstructured":"Jang, M. A. et al. Mutations in DDX58, which encodes RIG-I, cause atypical Singleton-Merten syndrome. Am. J. Hum. Genet. 96, 266\u2013274 (2015).","journal-title":"Am. J. Hum. Genet."},{"key":"BFsrep23377_CR8","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/path.4346","volume":"233","author":"X Suarez-Calvet","year":"2014","unstructured":"Suarez-Calvet, X. et al. Altered RIG-I\/DDX58-mediated innate immunity in dermatomyositis. J. Pathol. 233, 258\u2013268 (2014).","journal-title":"J. Pathol."},{"key":"BFsrep23377_CR9","first-page":"33","volume":"76","author":"J Maelfait","year":"2012","unstructured":"Maelfait, J. & Beyaert, R. Emerging role of ubiquitination in antiviral RIG-I signaling. Microbiol. Mol. Biol. Rev. 76, 33\u201345 (2012).","journal-title":"Emerging role of ubiquitination in antiviral RIG-I signaling. Microbiol. Mol. Biol. Rev."},{"key":"BFsrep23377_CR10","doi-asserted-by":"publisher","first-page":"3989","DOI":"10.1074\/jbc.M510787200","volume":"281","author":"W Zou","year":"2006","unstructured":"Zou, W. & Zhang, D. E. The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase. J. Biol. Chem. 281, 3989\u20133994 (2006).","journal-title":"J. Biol. Chem."},{"key":"BFsrep23377_CR11","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1038\/nature05732","volume":"446","author":"MU Gack","year":"2007","unstructured":"Gack, M. U. et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446, 916\u2013920 (2007).","journal-title":"Nature"},{"key":"BFsrep23377_CR12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s13238-010-0030-1","volume":"1","author":"Z Mi","year":"2010","unstructured":"Mi, Z., Fu, J., Xiong, Y. & Tang, H. SUMOylation of RIG-I positively regulates the type I interferon signaling. Protein & cell 1, 275\u2013283, doi: 10.1007\/s13238-010-0030-1 (2010).","journal-title":"Protein & cell"},{"key":"BFsrep23377_CR13","doi-asserted-by":"publisher","first-page":"14050","DOI":"10.1073\/pnas.0704014104","volume":"104","author":"N Jounai","year":"2007","unstructured":"Jounai, N. et al. The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc. Natl. Acad. Sci. USA. 104, 14050\u201314055 (2007).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"BFsrep23377_CR14","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1128\/JVI.01650-07","volume":"82","author":"MJ Kim","year":"2008","unstructured":"Kim, M. J., Hwang, S. Y., Imaizumi, T. & Yoo, J. Y. Negative feedback regulation of RIG-I-mediated antiviral signaling by interferon-induced ISG15 conjugation. J. Virol. 82, 1474\u20131483 (2008).","journal-title":"J. Virol."},{"key":"BFsrep23377_CR15","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.1128\/MCB.25.9.3483-3491.2005","volume":"25","author":"MS Hipp","year":"2005","unstructured":"Hipp, M. S., Kalveram, B., Raasi, S., Groettrup, M. & Schmidtke, G. FAT10, a ubiquitin-independent signal for proteasomal degradation. Mol. Cell. Biol. 25, 3483\u20133491 (2005).","journal-title":"Mol. Cell. Biol."},{"key":"BFsrep23377_CR16","doi-asserted-by":"publisher","first-page":"4313","DOI":"10.1073\/pnas.96.8.4313","volume":"96","author":"YC Liu","year":"1999","unstructured":"Liu, Y. C. et al. A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2. Proc. Natl. Acad. Sci. USA. 96, 4313\u20134318 (1999).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"BFsrep23377_CR17","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.1242\/jcs.087403","volume":"124","author":"J Ren","year":"2011","unstructured":"Ren, J., Wang, Y., Gao, Y., Mehta, S. B. & Lee, C. G. FAT10 mediates the effect of TNF-alpha in inducing chromosomal instability. J. Cell. Sci. 124, 3665\u20133675 (2011).","journal-title":"J. Cell. Sci."},{"key":"BFsrep23377_CR18","doi-asserted-by":"publisher","first-page":"4079","DOI":"10.1242\/jcs.035006","volume":"121","author":"B Kalveram","year":"2008","unstructured":"Kalveram, B., Schmidtke, G. & Groettrup, M. The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition. J. Cell. Sci. 121, 4079\u20134088 (2008).","journal-title":"J. Cell. Sci."},{"key":"BFsrep23377_CR19","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1038\/sj.onc.1206337","volume":"22","author":"CG Lee","year":"2003","unstructured":"Lee, C. G. et al. Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers. Oncogene 22, 2592\u20132603 (2003).","journal-title":"Oncogene"},{"key":"BFsrep23377_CR20","doi-asserted-by":"publisher","first-page":"6068","DOI":"10.1038\/onc.2008.201","volume":"27","author":"S Lukasiak","year":"2008","unstructured":"Lukasiak, S. et al. Proinflammatory cytokines cause FAT10 upregulation in cancers of liver and colon. Oncogene 27, 6068\u20136074 (2008).","journal-title":"Oncogene"},{"key":"BFsrep23377_CR21","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.molonc.2014.01.007","volume":"8","author":"Y Choi","year":"2014","unstructured":"Choi, Y., Kim, J. K. & Yoo, J. Y. NFkappaB and STAT3 synergistically activate the expression of FAT10, a gene counteracting the tumor suppressor p53. Mol. Oncol. 8, 642\u2013655 (2014).","journal-title":"Mol. Oncol."},{"key":"BFsrep23377_CR22","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/onc.2013.236","volume":"33","author":"L Liu","year":"2014","unstructured":"Liu, L. et al. As an independent prognostic factor, FAT10 promotes hepatitis B virus-related hepatocellular carcinoma progression via Akt\/GSK3beta pathway. Oncogene 33, 909\u2013920 (2014).","journal-title":"Oncogene"},{"key":"BFsrep23377_CR23","doi-asserted-by":"publisher","first-page":"5287","DOI":"10.1158\/0008-5472.CAN-14-0284","volume":"74","author":"R Yuan","year":"2014","unstructured":"Yuan, R. et al. Ubiquitin-like protein FAT10 promotes the invasion and metastasis of hepatocellular carcinoma by modifying beta-catenin degradation. Cancer Res. 74, 5287\u20135300 (2014).","journal-title":"Cancer Res."},{"key":"BFsrep23377_CR24","doi-asserted-by":"publisher","first-page":"e43031","DOI":"10.1371\/journal.pone.0043031","volume":"7","author":"K Onomoto","year":"2012","unstructured":"Onomoto, K. et al. Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity. PloS one 7, e43031, doi: 10.1371\/journal.pone.0043031 (2012).","journal-title":"PloS one"},{"key":"BFsrep23377_CR25","doi-asserted-by":"publisher","first-page":"9511","DOI":"10.1128\/JVI.03248-12","volume":"87","author":"CS Ng","year":"2013","unstructured":"Ng, C. S. et al. Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses. J. Virol. 87, 9511\u20139522 (2013).","journal-title":"J. Virol."},{"key":"BFsrep23377_CR26","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.1242\/jcs.107789","volume":"125","author":"A Aichem","year":"2012","unstructured":"Aichem, A. et al. The proteomic analysis of endogenous FAT10 substrates identifies p62\/SQSTM1 as a substrate of FAT10ylation. J. Cell. Sci. 125, 4576\u20134585 (2012).","journal-title":"J. Cell. Sci."},{"key":"BFsrep23377_CR27","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1091\/mbc.e11-07-0609","volume":"23","author":"S Buchsbaum","year":"2012","unstructured":"Buchsbaum, S., Bercovich, B. & Ciechanover, A. FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination. Mol. Biol. Cell. 23, 225\u2013232 (2012).","journal-title":"Mol. Biol. Cell."},{"key":"BFsrep23377_CR28","doi-asserted-by":"publisher","first-page":"16743","DOI":"10.1073\/pnas.0804947105","volume":"105","author":"MU Gack","year":"2008","unstructured":"Gack, M. U. et al. Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proc. Natl. Acad. Sci. USA 105, 16743\u201316748 (2008).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFsrep23377_CR29","doi-asserted-by":"crossref","unstructured":"Zhang, P. et al. TRIM25 has a dual function in the p53\/Mdm2 circuit. Oncogene, doi: 10.1038\/onc.2015.21 (2015).","DOI":"10.1038\/onc.2015.21"},{"key":"BFsrep23377_CR30","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.immuni.2011.03.026","volume":"34","author":"IC Allen","year":"2011","unstructured":"Allen, I. C. et al. NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-kappaB signaling pathways. Immunity 34, 854\u2013865 (2011).","journal-title":"Immunity"},{"key":"BFsrep23377_CR31","doi-asserted-by":"publisher","first-page":"e1004041","DOI":"10.1371\/journal.ppat.1004041","volume":"10","author":"Y Peng","year":"2014","unstructured":"Peng, Y., Xu, R. & Zheng, X. HSCARG negatively regulates the cellular antiviral RIG-I like receptor signaling pathway by inhibiting TRAF3 ubiquitination via recruiting OTUB1. PLoS Pathog. 10, e1004041, doi: 10.1371\/journal.ppat.1004041 (2014).","journal-title":"PLoS Pathog."},{"key":"BFsrep23377_CR32","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.cell.2010.03.040","volume":"141","author":"J Cui","year":"2010","unstructured":"Cui, J. et al. NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell. 141, 483\u2013496 (2010).","journal-title":"Cell."},{"key":"BFsrep23377_CR33","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1128\/JVI.01635-10","volume":"85","author":"M Solis","year":"2011","unstructured":"Solis, M. et al. RIG-I-mediated antiviral signaling is inhibited in HIV-1 infection by a protease-mediated sequestration of RIG-I. J. Virol. 85, 1224\u20131236 (2011).","journal-title":"J. Virol."},{"key":"BFsrep23377_CR34","doi-asserted-by":"publisher","first-page":"4572","DOI":"10.1128\/JVI.03021-13","volume":"88","author":"FW Santiago","year":"2014","unstructured":"Santiago, F. W. et al. Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses. J. Virol. 88, 4572\u20134585 (2014).","journal-title":"J. Virol."},{"key":"BFsrep23377_CR35","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/ng1383","volume":"36","author":"YK Hong","year":"2004","unstructured":"Hong, Y. K. et al. Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus. Nat. Genet. 36, 683\u2013685 (2004).","journal-title":"Nat. Genet."},{"key":"BFsrep23377_CR36","doi-asserted-by":"publisher","first-page":"11983","DOI":"10.1128\/JVI.00034-09","volume":"83","author":"A Snyder","year":"2009","unstructured":"Snyder, A. et al. FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. J. Virol. 83, 11983\u201311988, (2009).","journal-title":"J. Virol."},{"key":"BFsrep23377_CR37","doi-asserted-by":"publisher","first-page":"4883","DOI":"10.1242\/jcs.152371","volume":"127","author":"V Spinnenhirn","year":"2014","unstructured":"Spinnenhirn, V. et al. The ubiquitin-like modifier FAT10 decorates autophagy-targeted Salmonella and contributes to Salmonella resistance in mice. J. Cell. Sci. 127, 4883\u20134893 (2014).","journal-title":"J. Cell. Sci."},{"key":"BFsrep23377_CR38","doi-asserted-by":"publisher","first-page":"5180","DOI":"10.1128\/MCB.00966-05","volume":"26","author":"A Canaan","year":"2006","unstructured":"Canaan, A. et al. FAT10\/diubiquitin-like protein-deficient mice exhibit minimal phenotypic differences. Mol. Cell. Biol. 26, 5180\u20135189 (2006).","journal-title":"Mol. Cell. Biol."},{"key":"BFsrep23377_CR39","doi-asserted-by":"publisher","first-page":"4106","DOI":"10.4049\/jimmunol.1500592","volume":"195","author":"S Buerger","year":"2015","unstructured":"Buerger, S. et al. The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection. J. Immunol. 195, 4106\u20134116 (2015).","journal-title":"J. Immunol."},{"key":"BFsrep23377_CR40","doi-asserted-by":"publisher","first-page":"29594","DOI":"10.1074\/jbc.M111.261032","volume":"286","author":"Y Nagashima","year":"2011","unstructured":"Nagashima, Y., Kowa, H., Tsuji, S. & Iwata, A. FAT10 protein binds to polyglutamine proteins and modulates their solubility. J. Biol.Chem. 286, 29594\u201329600 (2011).","journal-title":"J. Biol.Chem."},{"key":"BFsrep23377_CR41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bbrc.2012.09.110","volume":"428","author":"S Buchsbaum","year":"2012","unstructured":"Buchsbaum, S., Bercovich, B., Ziv, T. & Ciechanover, A. Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS. Biochem. Biophys. Res. Commun. 428, 11\u201316 (2012).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFsrep23377_CR42","doi-asserted-by":"publisher","first-page":"6486","DOI":"10.1074\/jbc.M807547200","volume":"284","author":"A Mukherjee","year":"2009","unstructured":"Mukherjee, A. et al. Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. J. Biol.Chem. 284, 6486\u20136494 (2009).","journal-title":"J. Biol.Chem."},{"key":"BFsrep23377_CR43","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1242\/jcs.03424","volume":"120","author":"S Legrand-Poels","year":"2007","unstructured":"Legrand-Poels, S. et al. Modulation of Nod2-dependent NF-kappaB signaling by the actin cytoskeleton. J. Cell. Sci. 120, 1299\u20131310 (2007).","journal-title":"J. Cell. Sci."},{"key":"BFsrep23377_CR44","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0959-437X(00)00200-8","volume":"11","author":"M Goedert","year":"2001","unstructured":"Goedert, M. The significance of tau and alpha-synuclein inclusions in neurodegenerative diseases. Curr. Opin. Genet. Dev. 11, 343\u2013351 (2001).","journal-title":"Curr. Opin. Genet. Dev"},{"key":"BFsrep23377_CR45","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1093\/nar\/29.6.1341","volume":"29","author":"AS Balajee","year":"2001","unstructured":"Balajee, A. S. & Geard, C. R. Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells. Nucleic Acid. Res. 29, 1341\u20131351 (2001).","journal-title":"Nucleic Acid. Res."},{"key":"BFsrep23377_CR46","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1101\/gad.471708","volume":"22","author":"TC Tuoc","year":"2008","unstructured":"Tuoc, T. C. & Stoykova, A. Trim11 modulates the function of neurogenic transcription factor Pax6 through ubiquitin-proteosome system. Genes. Dev. 22, 1972\u20131986 (2008).","journal-title":"Genes. Dev."},{"key":"BFsrep23377_CR47","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrn1587","volume":"6","author":"PJ Muchowski","year":"2005","unstructured":"Muchowski, P. J. & Wacker, J. L. Modulation of neurodegeneration by molecular chaperones. Nat. Rev. Neurosci 6, 11\u201322 (2005).","journal-title":"Nat. Rev. Neurosci"},{"key":"BFsrep23377_CR48","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nature00826","volume":"417","author":"T Urano","year":"2002","unstructured":"Urano, T. et al. Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. Nature 417, 871\u2013875 (2002).","journal-title":"Nature"},{"key":"BFsrep23377_CR49","doi-asserted-by":"publisher","first-page":"7324","DOI":"10.4049\/jimmunol.181.10.7324","volume":"181","author":"MJ Kim","year":"2008","unstructured":"Kim, M. J. & Yoo, J. Y. Active caspase-1-mediated secretion of retinoic acid inducible gene-I. J. Immunol. 181, 7324\u20137331 (2008).","journal-title":"J. Immunol."},{"key":"BFsrep23377_CR50","doi-asserted-by":"publisher","first-page":"2724","DOI":"10.1093\/nar\/gkr1098","volume":"40","author":"SY Hwang","year":"2012","unstructured":"Hwang, S. Y. et al. 5\u2032-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity. Nucleic Acids. Res. 40, 2724\u20132733, doi: 10.1093\/nar\/gkr1098 (2012).","journal-title":"Nucleic Acids. Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep23377.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep23377","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep23377.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T03:59:59Z","timestamp":1672891199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep23377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,21]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,3,31]]}},"alternative-id":["BFsrep23377"],"URL":"https:\/\/doi.org\/10.1038\/srep23377","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,21]]},"assertion":[{"value":"9 October 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23377"}}