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SD (n\u2009=\u2009150) rats were randomly divided into three groups of normal, CCl<jats:sub>4<\/jats:sub>model and rhCygb groups. After model establishment, rats in rhCygb groups were administered daily with rhCygb (2\u2009mg\/kg, s.c.). Histological lesions were staged according to metavir. Serum parameters including ALT, AST, HA, LN, Col III and Col IV were determined. The liver proteins were separated by 2-DE and identified. As a result, the stage of hepatic damage and liver fibrosis in rhCygb groups were significantly milder than that in CCl<jats:sub>4<\/jats:sub>model groups. Meanwhile, rhCygb dramatically reversed serum levels of ALT and AST, and also markedly decreased the liver fibrosis markers levels of LN, HA, Col III and Col IV. In 2-DE, 33 proteins among three groups with the same changing tendency in normal and rhCygb treated groups compared with CCl<jats:sub>4<\/jats:sub>model group were identified. GO analysis showed that several identified proteins involved in oxidative stress pathway. The study provides new insights and data for administration of rhCygb reversing CCl<jats:sub>4<\/jats:sub>-induced liver fibrosis suggesting that rhCygb might be used in the treatment of liver fibrosis.<\/jats:p>","DOI":"10.1038\/srep23508","type":"journal-article","created":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T10:19:50Z","timestamp":1458728390000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Effect of rhCygb on CCl4-Induced Hepatic Fibrogenesis in Rat"],"prefix":"10.1038","volume":"6","author":[{"given":"Zhen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaotai","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,23]]},"reference":[{"key":"BFsrep23508_CR1","first-page":"G7","volume":"279","author":"FJ Eng","year":"2000","unstructured":"Eng, F. 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