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These are difficult to treat often due to drug resistance, particularly because\n                    <jats:italic>C. albicans<\/jats:italic>\n                    biofilms are inherently resistant to most antifungals. Sophorolipid (SL), a glycolipid biosurfactant, has been shown to have antimicrobial and anticancer properties. In this study, we investigated the effect of SL on\n                    <jats:italic>C. albicans<\/jats:italic>\n                    biofilm formation and preformed biofilms. SL was found to inhibit\n                    <jats:italic>C. albicans<\/jats:italic>\n                    biofilm formation as well as reduce the viability of preformed biofilms. Moreover, SL, when used along with amphotericin B (AmB) or fluconazole (FLZ), was found to act synergistically against biofilm formation and preformed biofilms. Effect of SL on\n                    <jats:italic>C. albicans<\/jats:italic>\n                    biofilm formation was further visualized by scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM), which revealed absence of hyphae, typical biofilm architecture and alteration in the morphology of biofilm cells. We also found that SL downregulates the expression of hypha specific genes\n                    <jats:italic>HWP1<\/jats:italic>\n                    ,\n                    <jats:italic>ALS1<\/jats:italic>\n                    ,\n                    <jats:italic>ALS3<\/jats:italic>\n                    ,\n                    <jats:italic>ECE1<\/jats:italic>\n                    and\n                    <jats:italic>SAP4<\/jats:italic>\n                    , which possibly explains the inhibitory effect of SL on hyphae and biofilm formation.\n                  <\/jats:p>","DOI":"10.1038\/srep23575","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T05:04:02Z","timestamp":1459400642000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":184,"title":["Inhibitory Effect of Sophorolipid on Candida albicans Biofilm Formation and Hyphal Growth"],"prefix":"10.1038","volume":"6","author":[{"given":"Farazul","family":"Haque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Alfatah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ganesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mani Shankar","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,31]]},"reference":[{"key":"BFsrep23575_CR1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.diagmicrobio.2012.10.003","volume":"74","author":"M Pfaller","year":"2012","unstructured":"Pfaller, M. et al. 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