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However, no randomized controlled trial has been published comparing SABG outcomes in patients with and without, presurgical orthodontic treatment. This randomized, prospective, single-blinded trial was conducted between January 2012 and April 2015 to compare ABG volumes 6 months postoperatively between patients with and without presurgical orthodontic treatment. Twenty-four patients were enrolled and randomized and 22 patients completed follow-up. Patients who had presurgical orthodontics before SABG had significantly improved inclination (p\u2009&lt;\u20090.001) and rotation (p\u2009&lt;\u20090.001) of the central incisor adjacent to the defect, significantly improved ABG fill volume (0.81\u2009\u00b1\u20090.26\u2009cm<jats:sup>3<\/jats:sup> at 6 months compared to 0.59\u2009\u00b1\u20090.22\u2009cm<jats:sup>3<\/jats:sup>; p\u2009&lt;\u20090.05) and less residual alveolar bone defect (0.31\u2009\u00b1\u20090.08\u2009cm<jats:sup>3<\/jats:sup> at 6 months compared to s 0.55\u2009\u00b1\u20090.14\u2009cm<jats:sup>3<\/jats:sup>; p\u2009&lt;\u20090.001) compared to patients who did not have presurgical orthodontic treatment. In conclusion, orthodontic treatment combined with SABG results in superior bone volume when compared with conventional SABG alone.<\/jats:p>","DOI":"10.1038\/srep23597","type":"journal-article","created":{"date-parts":[[2016,4,4]],"date-time":"2016-04-04T11:32:22Z","timestamp":1459769542000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Difference in the Surgical Outcome of Unilateral Cleft Lip and Palate Patients with and without Pre-Alveolar Bone Graft Orthodontic Treatment"],"prefix":"10.1038","volume":"6","author":[{"given":"Chun-Shin","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Glenn","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Chang","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty Chien-Jung","family":"Pai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Ju","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Fang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Jen-Wein","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Kuo-Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyh-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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