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According to the 2015 WHO classification system, LAC constituents are required to be precisely reported. T790M mutation and an insertion in exon 20 (E20ins) are associated with <jats:italic>EGFR<\/jats:italic>-TKI resistance. A total of 211 LAC patients were involved in this study, and <jats:italic>EGFR<\/jats:italic> mutations were determined using an amplification refractory mutation system (ARMS). Sex, smoking history, lymph node status, and clinical stage differed significantly between the <jats:italic>EGFR<\/jats:italic> wild type and mutant groups (p\u2009&lt;\u20090.05). The <jats:italic>EGFR<\/jats:italic> mutation occurred more frequently in female, non-smokers, ACs with papillary (85.7%) or MP components (91.4%) (p\u2009&lt;\u20090.001). Twenty ACs with na\u00efve T790M or E20ins were microdissected. The AC constituents metastasizing to lymph nodes exhibited a phenotype and EGFR status that was consistent with the primary loci constituents. Glomerulus-like solid components exhibited the same <jats:italic>EGFR<\/jats:italic> status as the surrounding T790M-mutated MP components. The MP and glomerulus-like portions in AC tumours exhibited a congenial <jats:italic>EGFR<\/jats:italic> status, but the acinar cells with papillary cells were heterogeneous. The na\u00efve T790M mutants, although minor in the MP component, dramatically increased after <jats:italic>EGFR<\/jats:italic>-TKI therapy and indicate that the MP components feature intrinsic heterogeneity.<\/jats:p>","DOI":"10.1038\/srep23755","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T09:14:00Z","timestamp":1459847640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Micropapillary: A component more likely to harbour heterogeneous EGFR mutations in lung adenocarcinomas"],"prefix":"10.1038","volume":"6","author":[{"given":"Yi-Ran","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jie","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Bo","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Chen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Juan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,4,5]]},"reference":[{"key":"BFsrep23755_CR1","unstructured":"Curado, M. 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