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We identified LLC in meningeal, cortical and neurogenic brain regions. The density of cerebral LLC increased with age. LLC presenting small lipid droplets were visualized adjacent to blood vessels or deeper in the brain cortical and striatal parenchyma of aging mice. LLC with larger droplets were asymmetrically distributed in the cerebral ventricle walls, mainly located in the lateral wall. We also found that LLC in the subventricular region co-expressed beclin-1 or LC3, markers for autophagosome or autophagolysosome formation and perilipin (PLIN), a lipid droplet-associated protein, suggesting lipophagic activity. Some cerebral LLC exhibited \u03b2 galactosidase activity indicating a senescence phenotype. Moreover, we detected production of the pro-inflammatory cytokine TNF-\u03b1 in cortical PLIN<jats:sup>+<\/jats:sup> LLC. Some cortical NeuN<jats:sup>+<\/jats:sup> neurons, GFAP<jats:sup>+<\/jats:sup> glia limitans astrocytes, Iba-1<jats:sup>+<\/jats:sup> microglia and S100\u03b2<jats:sup>+<\/jats:sup> ependymal cells expressed PLIN in the aging brain. 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