{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:48:32Z","timestamp":1781279312635,"version":"3.54.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recurrent miscarriage (RM) is the occurrence of repeated pregnancies that end in miscarriage of the fetus before 20 weeks of gestation. At least 50% of the RM patients are considered idiopathic. High IL-33 levels are critical in early pregnancy and impact the outcome of subsequent pregnancies. However, the association of polymorphisms of <jats:italic>IL-33<\/jats:italic> with idiopathic RM is still unclear. The present study was initiated to investigate whether <jats:italic>IL-33<\/jats:italic> polymorphisms are risk factors for idiopathic RM in Chinese Han population. Study subjects comprised of 321 cases and 384 controls. Five polymorphisms (rs10435816, rs16924159, rs16924171, rs1929992, rs1332290) in <jats:italic>IL-33<\/jats:italic> and serum IL-33 concentrations were assessed. rs16924159 variant exhibits significant association with RM in additive and recessive genetic model (additive model <jats:italic>P<\/jats:italic>\u2009=\u20090.015, recessive model <jats:italic>P<\/jats:italic>\u2009=\u20090.007). In contrast, rs10435816, rs16924171, rs1929992 and rs1332290 are not significantly associated with RM. Serum IL-33 levels are significantly lower in RM cases than in control (173.51\u2009\u00b1\u200994.12 versus. 200.97\u2009\u00b1\u2009110.06 (pg\/ml), <jats:italic>P<\/jats:italic>\u2009=\u20094.57\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>). There are lower levels of serum IL-33 in rs16924159 homozygous mutant (AA) than homozygous wild-type (GG) in this study population, including cases and control groups (172.18\u2009\u00b1\u2009103.01 versus. 205.82\u2009\u00b1\u2009119.01 (pg\/ml), <jats:italic>P<\/jats:italic>\u2009=\u20090.006). Reduced IL-33 levels and rs16924159 <jats:italic>IL-33<\/jats:italic> variant may contribute to the pathogenesis of idiopathic RM in Chinese Han population.<\/jats:p>","DOI":"10.1038\/srep23806","type":"journal-article","created":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T09:15:55Z","timestamp":1459329355000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Genetic variant in IL-33 is associated with idiopathic recurrent miscarriage in Chinese Han population"],"prefix":"10.1038","volume":"6","author":[{"given":"Jun","family":"Yue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"BFsrep23806_CR1","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1056\/NEJMcp1005330","volume":"363","author":"DW Branch","year":"2010","unstructured":"Branch, D. 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