{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T08:02:49Z","timestamp":1773475369950,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T00:00:00Z","timestamp":1459987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schistosomiasis remains a major public health problem and causes substantial economic impact in east China, particularly along the Yangtze River Basin. Disease forecasting and surveillance can assist in the development and implementation of more effective intervention measures to control disease. In this study, we applied a Bayesian hierarchical spatio-temporal model to describe trends in schistosomiasis risk in Anhui Province, China, using annual parasitological and environmental data for the period 1997\u20132010. A computationally efficient approach\u2013Integrated Nested Laplace Approximation\u2013was used for model inference. A zero-inflated, negative binomial model best described the spatio-temporal dynamics of schistosomiasis risk. It predicted that the disease risk would generally be low and stable except for some specific, local areas during the period 2011\u20132014. High-risk counties were identified in the forecasting maps: three in which the risk remained high, and two in which risk would become high. The results indicated that schistosomiasis risk has been reduced to consistently low levels throughout much of this region of China; however, some counties were identified in which progress in schistosomiasis control was less than satisfactory. Whilst maintaining overall control, specific interventions in the future should focus on these refractive counties as part of a strategy to eliminate schistosomiasis from this region.<\/jats:p>","DOI":"10.1038\/srep24173","type":"journal-article","created":{"date-parts":[[2016,4,7]],"date-time":"2016-04-07T09:31:22Z","timestamp":1460021482000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Monitoring schistosomiasis risk in East China over space and time using a Bayesian hierarchical modeling approach"],"prefix":"10.1038","volume":"6","author":[{"given":"Yi","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Congcong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Lynn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenghua","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qizhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenglong","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingwu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,4,7]]},"reference":[{"key":"BFsrep24173_CR1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1517\/14656566.5.2.263","volume":"5","author":"J Utzinger","year":"2004","unstructured":"Utzinger, J. & Keiser, J. Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control. Expert Opin Pharmacother 5, 263\u201385 (2004).","journal-title":"Expert Opin Pharmacother"},{"key":"BFsrep24173_CR2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S1473-3099(10)70099-2","volume":"10","author":"DJ Gray","year":"2010","unstructured":"Gray, D. J. et al. Schistosomiasis elimination: lessons from the past guide the future. Lancet Infect Dis 10, 733\u2013736 (2010).","journal-title":"Lancet Infect Dis"},{"key":"BFsrep24173_CR3","unstructured":"WHO. schistosomiasis. (2015) Available at: http:\/\/ www.who.int\/mediacentre\/factsheets\/fs115\/en\/. (Accessed: 5th July 2015)."},{"key":"BFsrep24173_CR4","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1016\/S2214-109X(13)70089-5","volume":"1","author":"RV Krishnamurthi","year":"2013","unstructured":"Krishnamurthi, R. V. et al. Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990\u20132010: findings from the Global Burden of Disease Study 2010. Lancet Glob Health 1, e259\u201381 (2013).","journal-title":"Lancet Glob Health"},{"key":"BFsrep24173_CR5","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/S0140-6736(06)69440-3","volume":"368","author":"B Gryseels","year":"2006","unstructured":"Gryseels, B., Polman, K., Clerinx, J. & Kestens, L. Human schistosomiasis. Lancet 368, 1106\u20131118 (2006).","journal-title":"Lancet"},{"key":"BFsrep24173_CR6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1383-5769(99)00004-5","volume":"48","author":"M Chen","year":"1999","unstructured":"Chen, M. & Feng, Z. Schistosomiasis control in China. Parasitol Int 48, 11\u201319 (1999).","journal-title":"Parasitol Int"},{"key":"BFsrep24173_CR7","first-page":"591","volume":"26","author":"Z Lei","year":"2014","unstructured":"Lei, Z. et al. Endemic status of schistosomiasis in People\u2019s Republic of China in 2013. Chin J Schisto Control 26, 591\u2013597 (2014).","journal-title":"Chin J Schisto Control"},{"key":"BFsrep24173_CR8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0001-706X(02)00263-2","volume":"85","author":"W Zhang","year":"2003","unstructured":"Zhang, W. & Wong, C. M. Evaluation of the 1992\u20131999 World Bank Schistosomiasis Control Project in China. Acta Trop 85, 303\u2013313 (2003).","journal-title":"Acta Trop"},{"key":"BFsrep24173_CR9","first-page":"1009","volume":"122","author":"SZ Li","year":"2009","unstructured":"Li, S. Z. et al. Schistosomiasis in China: acute infections during 2005\u20132008. Chin Med J (Engl) 122, 1009\u201314 (2009).","journal-title":"Chin Med J (Engl)"},{"key":"BFsrep24173_CR10","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1128\/CMR.00044-09","volume":"23","author":"DP McManus","year":"2010","unstructured":"McManus, D. P. et al. schistosomasis in the People\u2019s Republic of China: the Era of the Three Gorges Dam. Clin Microbiol Rev 23, 442\u2013466 (2010).","journal-title":"Clin Microbiol Rev"},{"key":"BFsrep24173_CR11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2049-9957-1-8","volume":"1","author":"C Collions","year":"2012","unstructured":"Collions, C., Xu, J. & Tang, S. Schistosomiasis control and the health system in P.R. China. Infect Dis Poverty 1, 8 (2012).","journal-title":"Infect Dis Poverty"},{"key":"BFsrep24173_CR12","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.actatropica.2005.07.021","volume":"96","author":"XH Wu","year":"2005","unstructured":"Wu, X. H., Chen, M. G. & Zheng, J. Surveillance of schistosomiasis in five provinces of China which have reached the national criteria for elimination of the disease. Acta Trop 96, 276\u201381 (2005).","journal-title":"Acta Trop"},{"key":"BFsrep24173_CR13","unstructured":"Zhu, H., Cai, S. X. & Gao, X. B. Preliminary effect of comprehensive measures with emphasis on infectious source control for schistosomiasis control in Hubei Province. Chin J Schisto Control 21 (2009)."},{"key":"BFsrep24173_CR14","doi-asserted-by":"crossref","first-page":"e1620","DOI":"10.1371\/journal.pntd.0001620","volume":"6","author":"Z Zhang","year":"2012","unstructured":"Zhang, Z. et al. Long-term impact of the World Bank Loan Project for schistosomiasis control: a comparison of the spatial distribution of schistosomiasis risk in China. PLos Negl Trop Dis 6, e1620 (2012).","journal-title":"PLos Negl Trop Dis"},{"key":"BFsrep24173_CR15","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3390\/ijerph110100701","volume":"11","author":"Y Hu","year":"2014","unstructured":"Hu, Y. et al. Changing patterns of spatial clustering of schistosomiasis in Southwest China between 1999\u20132001 and 2007\u20132008: assessing progress toward eradication after the World Bank Loan Project. Int J Environ Res Public Health 11, 701\u201312 (2014).","journal-title":"Int J Environ Res Public Health"},{"key":"BFsrep24173_CR16","unstructured":"Zhu, R., Zhao, G. M. & Huang, X. B. Development and prospect of surveillance network of schistosom iasis in China. Chin J Schisto Control 23 (2011)."},{"key":"BFsrep24173_CR17","first-page":"863","volume":"25","author":"XY Sai","year":"2004","unstructured":"Sai, X. Y. et al. Application of \u201ctime series analysis\u201d in the prediction of schistosomiasis prevalence in areas of \u201cbreaking dikes or opening sluice for waterstore\u201d in Dongting Lake areas, China. Chin J Epidemio 25, 863\u20136 (2004).","journal-title":"Chin J Epidemio"},{"key":"BFsrep24173_CR18","doi-asserted-by":"crossref","first-page":"e276","DOI":"10.1371\/journal.pntd.0000276","volume":"2","author":"DC Medina","year":"2008","unstructured":"Medina, D. C., Findley, S. E. & Doumbia, S. State-space forecasting of Schistosoma haematobium time-series in Niono, Mali. PLos Negl Trop Dis 2, e276 (2008).","journal-title":"PLos Negl Trop Dis"},{"key":"BFsrep24173_CR19","first-page":"345","volume":"21","author":"Y Hao","year":"2009","unstructured":"Hao, Y. et al. Causes and risks of schistosomiasis transmission in Poyang Lake region of Jiangxi Province, China. Chin J Schisto Control 21, 345\u2013349 (2009).","journal-title":"Chin J Schisto Control"},{"key":"BFsrep24173_CR20","doi-asserted-by":"crossref","first-page":"e104875","DOI":"10.1371\/journal.pone.0104875","volume":"9","author":"LL Zhou","year":"2014","unstructured":"Zhou, L. L. et al. A hybrid model for predicting the prevalence of schistosomiasis in humans of Qianjiang City, China. PLos One 9, e104875 (2014).","journal-title":"PLos One"},{"key":"BFsrep24173_CR21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4269\/ajtmh.2006.75.549","volume":"75","author":"GJ Yang","year":"2006","unstructured":"Yang, G. J. et al. A growing degree-days based time-series analysis for prediction of Schistosoma japonicum transmission in Jiangsu province, China. Am J Trop Med Hyg 75, 549\u201355 (2006).","journal-title":"Am J Trop Med Hyg"},{"key":"BFsrep24173_CR22","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/1467-9868.00353","volume":"64","author":"DJ Spiegelhalter","year":"2002","unstructured":"Spiegelhalter, D. J., Best, N. G., Carlin, B. P. & Van Der Linde, A. Bayesian measures of model complexity and fit. J R Stat Soc B 64, 583\u2013639 (2002).","journal-title":"J R Stat Soc B"},{"key":"BFsrep24173_CR23","doi-asserted-by":"crossref","unstructured":"Berliner, L. M. Hierarchical Bayesian time-series models. In Maximum Entropy and Bayesian Methods 15\u201322 (Kluwer Academic Publishers, Dordrecht, NL, 1996).","DOI":"10.1007\/978-94-011-5430-7_3"},{"key":"BFsrep24173_CR24","first-page":"481","volume":"18","author":"TP Pesigan","year":"1958","unstructured":"Pesigan, T. P. et al. Studies on Schistosoma japonicum infection in the Philippines. 2. The molluscan host. Bull World Health Organ 18, 481\u2013578 (1958).","journal-title":"Bull World Health Organ"},{"key":"BFsrep24173_CR25","doi-asserted-by":"crossref","first-page":"188","DOI":"10.4269\/ajtmh.2008.78.188","volume":"78","author":"XN Zhou","year":"2008","unstructured":"Zhou, X. N. et al. Potential impact of climate change on schistosomiasis transmission in China. Am J Trop Med Hyg 78, 188\u201394 (2008).","journal-title":"Am J Trop Med Hyg"},{"key":"BFsrep24173_CR26","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/S0140-6736(03)14968-9","volume":"362","author":"J Utzinger","year":"2003","unstructured":"Utzinger, J., Bergquist, R., Shu-Hua, X., Singer, B. H. & Tanner, M. Sustainable schistosomiasis control\u2013the way forward. Lancet 362, 1932\u20134 (2003).","journal-title":"Lancet"},{"key":"BFsrep24173_CR27","first-page":"555","volume":"25","author":"XN Zhou","year":"2004","unstructured":"Zhou, X. N. et al. The current status of schistosomiasis epidemics in China. Chin J Epidemio 25, 555\u20138 (2004).","journal-title":"Chin J Epidemio"},{"key":"BFsrep24173_CR28","first-page":"437","volume":"17","author":"S Zhang","year":"2005","unstructured":"Zhang, S. et al. Observation on comprehensive measures of safe treatment of night-soil and water supply, replacement of bovine with machine for schistosomiasis control. Chin J Schisto Control 17, 437\u2013442 (2005).","journal-title":"Chin J Schisto Control"},{"key":"BFsrep24173_CR29","first-page":"43","volume":"83","author":"XY Chen","year":"2005","unstructured":"Chen, X. Y. et al. Schistosomiasis control in China: the impact of a 10-year World Bank Loan Project (1992\u20132001). Bull World Health Organ 83, 43\u201348 (2005).","journal-title":"Bull World Health Organ"},{"key":"BFsrep24173_CR30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/1756-3305-5-275","volume":"5","author":"YB Zhou","year":"2012","unstructured":"Zhou, Y. B., Liang, S. & Jiang, Q. W. Factors impacting on progress towards elimination of transmission of schistosomiasis japonica in China. Parasit Vectors 5, 275 (2012).","journal-title":"Parasit Vectors"},{"key":"BFsrep24173_CR31","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/1756-3305-6-138","volume":"6","author":"K Yang","year":"2013","unstructured":"Yang, K. et al. Spatio-temporal analysis to identify determinants of Oncomelania hupensis infection with Schistosoma japonicum in Jiangsu province, China. Parasit Vectors 6, 138 (2013).","journal-title":"Parasit Vectors"},{"key":"BFsrep24173_CR32","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2471\/BLT.08.058933","volume":"87","author":"AC Clements","year":"2009","unstructured":"Clements, A. C., Firth, S., Dembele, R. & Garba, A. Use of Bayesian geostatistical prediction to estimate local variations in Schistosoma haematobium infection in West Africa. Bulletin of the World Health Organization 87, 921\u2013929 (2009).","journal-title":"Bulletin of the World Health Organization"},{"key":"BFsrep24173_CR33","doi-asserted-by":"crossref","first-page":"547","DOI":"10.4269\/ajtmh.14-0251","volume":"91","author":"Y Hu","year":"2014","unstructured":"Hu, Y. et al. Spatio-Temporal Patterns of Schistosomiasis Japonica in Lake and Marshland Areas in China: The Effect of Snail Habitats. Am J Trop Med Hyg 91, 547\u2013554 (2014).","journal-title":"Am J Trop Med Hyg"},{"key":"BFsrep24173_CR34","doi-asserted-by":"crossref","first-page":"e0003470","DOI":"10.1371\/journal.pntd.0003470","volume":"9","author":"Y Hu","year":"2015","unstructured":"Hu, Y. et al. Spatio-temporal Transmission and Environmental Determinants of Schistosomiasis Japonica in Anhui Province, China. PLos Negl Trop Dis 9, e0003470 (2015).","journal-title":"PLos Negl Trop Dis"},{"key":"BFsrep24173_CR35","unstructured":"Cressie, N. & Wikle, C. K. Statistics for spatio-temporal data, xxii, 588 (Wiley, 2011)."},{"key":"BFsrep24173_CR36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-308X(08)60561-8","volume":"24","author":"RM Anderson","year":"1985","unstructured":"Anderson, R. M. & May, R. M. Helminth infections of humans: mathematical models, population dynamics, and control. Adv Parasitol 24, 1\u2013101 (1985).","journal-title":"Adv Parasitol"},{"key":"BFsrep24173_CR37","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2334-4-13","volume":"4","author":"M Booth","year":"2004","unstructured":"Booth, M. et al. Micro-geographical variation in exposure to Schistosoma mansoni and malaria, and exacerbation of splenomegaly in Kenyan school-aged children. BMC Infect Dis 4, 13 (2004).","journal-title":"BMC Infect Dis"},{"key":"BFsrep24173_CR38","doi-asserted-by":"crossref","first-page":"e250","DOI":"10.1371\/journal.pntd.0000250","volume":"2","author":"XH Wang","year":"2008","unstructured":"Wang, X. H. et al. Bayesian spatio-temporal modeling of Schistosoma japonicum prevalence data in the absence of a diagnostic \u2018gold\u2019 standard. PLos Negl Trop Dis 2, e250 (2008).","journal-title":"PLos Negl Trop Dis"},{"key":"BFsrep24173_CR39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.parint.2006.11.002","volume":"56","author":"JM Yu","year":"2007","unstructured":"Yu, J. M., de Vlas, S. J., Jiang, Q. W. & Gryseels, B. Comparison of the Kato-Katz technique, hatching test and indirect hemagglutination assay (IHA) for the diagnosis of Schistosoma japonicum infection in China. Parasitol Int 56, 45\u20139 (2007).","journal-title":"Parasitol Int"},{"key":"BFsrep24173_CR40","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijpara.2004.11.002","volume":"35","author":"GJ Yang","year":"2005","unstructured":"Yang, G. J., Vounatsou, P., Zhou, X. N., Tanner, M. & Utzinger, J. A Bayesian-based approach for spatio-temporal modeling of county level prevalence of Schistosoma japonicum infection in Jiangsu province, China. Int J Parasitol 35, 155\u201362 (2005).","journal-title":"Int J Parasitol"},{"key":"BFsrep24173_CR41","doi-asserted-by":"crossref","first-page":"e431","DOI":"10.1371\/journal.pntd.0000431","volume":"3","author":"AC Clements","year":"2009","unstructured":"Clements, A. C. et al. A comparative study of the spatial distribution of schistosomiasis in Mali in 1984\u20131989 and 2004\u20132006. PLos Negl Trop Dis 3, e431 (2009).","journal-title":"PLos Negl Trop Dis"},{"key":"BFsrep24173_CR42","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/1756-3305-6-214","volume":"6","author":"Y Hu","year":"2013","unstructured":"Hu, Y. et al. Spatial pattern of schistosomiasis in Xingzi, Jiangxi Province, China: the effects of environmental factors. Parasit Vectors 6, 214 (2013).","journal-title":"Parasit Vectors"},{"key":"BFsrep24173_CR43","unstructured":"Ridout, M., Demetrio, C. G. & Hinde, J. Models for count data with many zeros. in Proceedings of the XIX International Biometric Conference (Cape Town, South Africa, 1998)."},{"key":"BFsrep24173_CR44","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1198\/106186008X340760","volume":"17","author":"N Cressie","year":"2008","unstructured":"Cressie, N. & Kapat, P. Some diagnostics for Markov random fields. J Comp Graph Stat 17, 726\u201349 (2008).","journal-title":"J Comp Graph Stat"},{"key":"BFsrep24173_CR45","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1002\/sim.1217","volume":"21","author":"AS Mugglin","year":"2002","unstructured":"Mugglin, A. S., Cressie, N. & Gemmell, I. Hierarchical statistical modelling of influenza epidemic dynamics in space and time. Stat Med 21, 2703\u201321 (2002).","journal-title":"Stat Med"},{"key":"BFsrep24173_CR46","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1016\/j.jspi.2006.07.016","volume":"137","author":"HV Rue","year":"2007","unstructured":"Rue, H. V. & Martino, S. Approximate Bayesian inference for hierarchical Gaussian Markov random field models. J Stat Plan Infer 137, 3177\u20133192 (2007).","journal-title":"J Stat Plan Infer"},{"key":"BFsrep24173_CR47","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1016\/j.csda.2011.10.024","volume":"56","author":"R Ruiz-C\u00e1rdenas","year":"2012","unstructured":"Ruiz-C\u00e1rdenas, R., Krainski, E. T. & Rue, H. V. Direct fitting of dynamic models using integrated nested Laplace approximations \u2014 INLA. Comput. Stat. Data Anal. 56, 1808\u20131828 (2012).","journal-title":"Comput. Stat. Data Anal."},{"key":"BFsrep24173_CR48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.sste.2012.12.001","volume":"4","author":"M Blangiardo","year":"2013","unstructured":"Blangiardo, M., Cameletti, M., Baio, G. & Rue, H. Spatial and spatio-temporal models with R-INLA. Spat Spatiotemporal Epidemiol 4, 33\u201349 (2013).","journal-title":"Spat Spatiotemporal Epidemiol"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep24173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep24173","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep24173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T04:31:52Z","timestamp":1672893112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep24173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,7]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,4,26]]}},"alternative-id":["BFsrep24173"],"URL":"https:\/\/doi.org\/10.1038\/srep24173","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,7]]},"assertion":[{"value":"6 October 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24173"}}