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However, how it affects AD occurrence is still unknown. Brain reserve hypothesis highlights the tolerant capacities of brain as a passive means to fight against neurodegenerations. Here, we took the baseline volume and\/or thickness of LOAD-associated brain regions as proxies of brain reserve capacities and investigated whether <jats:italic>PICALM<\/jats:italic> genetic variations can influence the baseline reserve capacities and the longitudinal atrophy rate of these specific regions using data from Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI) dataset. In mixed population, we found that brain region significantly affected by <jats:italic>PICALM<\/jats:italic> genetic variations was majorly restricted to posterior cingulate. In sub-population analysis, we found that one <jats:italic>PICALM<\/jats:italic> variation (C allele of rs642949) was associated with larger baseline thickness of posterior cingulate in health. We found seven variations in health and two variations (rs543293 and rs592297) in individuals with mild cognitive impairment were associated with slower atrophy rate of posterior cingulate. Our study provided preliminary evidences supporting that <jats:italic>PICALM<\/jats:italic> variations render protections by facilitating reserve capacities of posterior cingulate in non-demented elderly.<\/jats:p>","DOI":"10.1038\/srep24480","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T08:53:09Z","timestamp":1461747189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD 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