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Recently, miR-21 has emerged as a key omnipotent player in carcinogenesis, including brain tumors. It is recognized as an indicator of glioma prognosis and a prosperous target for anti-tumor therapy. Here we show that rationally designed hammerhead ribozymes and DNAzymes can target miR-21 and\/or its precursors. They decrease miR-21 level and thus silence this oncomiR functions. We demonstrated that anti-miRNA catalytic nucleic acids show a novel terrific arsenal for specific and effective combat against diseases with elevated cellular miR-21 content, such as brain tumors.<\/jats:p>","DOI":"10.1038\/srep24516","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T05:35:30Z","timestamp":1460698530000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Inhibition of miR-21 in glioma cells using catalytic nucleic acids"],"prefix":"10.1038","volume":"6","author":[{"given":"Agnieszka","family":"Belter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Rolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Piwecka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Fedoruk-Wyszomirska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miros\u0142awa Z.","family":"Naskr\u0119t-Barciszewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Barciszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,15]]},"reference":[{"key":"BFsrep24516_CR1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.pathol.1.110304.100043","volume":"1","author":"DN Louis","year":"2006","unstructured":"Louis, D. 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