{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T21:58:30Z","timestamp":1787003910731,"version":"build-2736575974"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T00:00:00Z","timestamp":1461542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T00:00:00Z","timestamp":1461542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We assessed exercise performance, coronary blood flow and cardiac reserve of female ApoE\/LDLR\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice with advanced atherosclerosis compared with age-matched, wild-type C57BL6\/J mice. Exercise capacity was assessed as whole body maximal oxygen consumption (V\u2019O\n                    <jats:sub>2max<\/jats:sub>\n                    ), maximum running velocity (v\n                    <jats:sub>max<\/jats:sub>\n                    ) and maximum distance (DIST\n                    <jats:sub>max<\/jats:sub>\n                    ) during treadmill exercise. Cardiac systolic and diastolic function in basal conditions and in response to dobutamine (mimicking exercise-induced cardiac stress) were assessed by Magnetic Resonance Imaging (MRI)\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Function of coronary circulation was assessed in isolated perfused hearts. In female ApoE\/LDLR\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice V\u2019O\n                    <jats:sub>2max<\/jats:sub>\n                    , v\n                    <jats:sub>max<\/jats:sub>\n                    and DIST\n                    <jats:sub>max<\/jats:sub>\n                    were not impaired as compared with C57BL6\/J mice. Cardiac function at rest and systolic and diastolic cardiac reserve were also preserved in female ApoE\/LDLR\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice as evidenced by preserved fractional area change and similar fall in systolic and end diastolic area after dobutamine. Moreover, endothelium-dependent responses of coronary circulation induced by bradykinin (Bk) and acetylcholine (ACh) were preserved, while endothelium-independent responses induced by NO-donors were augmented in female ApoE\/LDLR\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Basal COX-2-dependent production of 6-keto-PGF\n                    <jats:sub>1\u03b1<\/jats:sub>\n                    was increased. Concluding, we suggest that robust compensatory mechanisms in coronary circulation involving PGI\n                    <jats:sub>2<\/jats:sub>\n                    - and NO-pathways may efficiently counterbalance coronary atherosclerosis-induced impairment in V\u2019O\n                    <jats:sub>2max<\/jats:sub>\n                    and exercise capacity.\n                  <\/jats:p>","DOI":"10.1038\/srep24714","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T05:15:58Z","timestamp":1461561358000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Exercise capacity and cardiac hemodynamic response in female ApoE\/LDLR\u2212\/\u2212 mice: a paradox of preserved V\u2019O2max and exercise capacity despite coronary atherosclerosis"],"prefix":"10.1038","volume":"6","author":[{"given":"M.","family":"Wojewoda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Tyrankiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gwozdz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Skorka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jablonska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Orzylowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Jasinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jasztal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Przyborowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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