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A literature search in PubMed, Embase, and Web of Sciencewas conducted to obtain relevant publications. Finally a total of 16 articles with 24 case-control studies (nine on\n                    <jats:italic>MMP<\/jats:italic>\n                    -9-1562 C\/T, seven on\n                    <jats:italic>MMP<\/jats:italic>\n                    -3-1171 A5\/A6, four on\n                    <jats:italic>MMP<\/jats:italic>\n                    -2-753C\/T, and four on\n                    <jats:italic>MMP<\/jats:italic>\n                    -8-799 C\/T) were considered in this meta-analysis. The results based on 2,724 periodontitis patients and 3,438 controls showed that\n                    <jats:italic>MMP<\/jats:italic>\n                    -9-1562C\/T,\n                    <jats:italic>MMP<\/jats:italic>\n                    -3-1171 A5\/A6, and\n                    <jats:italic>MMP<\/jats:italic>\n                    -8-799C\/T polymorphisms were associated with periodontitis susceptibility. No significant association was found between\n                    <jats:italic>MMP<\/jats:italic>\n                    -2-753 C\/T and periodontitis susceptibility. Subgroup analyses suggested that the\n                    <jats:italic>MMP<\/jats:italic>\n                    -9-1562 C\/T polymorphism reduced chronic periodontitis susceptibility and\n                    <jats:italic>MMP<\/jats:italic>\n                    -3-1171 A5\/A6polymorphism increased chronic periodontitis susceptibility. In summary, current evidence demonstrated that\n                    <jats:italic>MMP<\/jats:italic>\n                    -9-753 C\/Tpolymorphism reduced the risk of periodontitis,\n                    <jats:italic>MMP<\/jats:italic>\n                    -3-1171 5A\/6A and\n                    <jats:italic>MMP<\/jats:italic>\n                    -8-799 C\/Tpolymorphisms increased the risk of periodontitis, and\n                    <jats:italic>MMP<\/jats:italic>\n                    -2-753 C\/T was not associated with risk of periodontitis.\n                  <\/jats:p>","DOI":"10.1038\/srep24812","type":"journal-article","created":{"date-parts":[[2016,4,20]],"date-time":"2016-04-20T05:50:22Z","timestamp":1461131422000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta-analysis involving 6,162 individuals"],"prefix":"10.1038","volume":"6","author":[{"given":"Hong","family":"Weng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hui","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Yu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Yuan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-Tao","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,20]]},"reference":[{"key":"BFsrep24812_CR1","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","volume":"366","author":"BL Pihlstrom","year":"2005","unstructured":"Pihlstrom, B. 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