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The copepod is resistant to this toxic alga, but little is known about other effects. Gene expression profiles were used to investigate the physiological response of females feeding for two and five days on a control diet or a diet containing either a low or a high dose of <jats:italic>A. fundyense<\/jats:italic>. The physiological responses to the two experimental diets were similar, but changed between the time points. At 5-days the response was characterized by down-regulated genes involved in energy metabolism. Detoxification was not a major component of the response. Instead, genes involved in digestion were consistently regulated, suggesting that food assimilation may have been affected. Thus, predicted increases in the frequency of blooms of <jats:italic>A. fundyense<\/jats:italic> could affect <jats:italic>C. finmarchicus<\/jats:italic> populations by changing the individuals\u2019 energy budget and reducing their ability to build lipid reserves.<\/jats:p>","DOI":"10.1038\/srep25708","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T09:01:21Z","timestamp":1463389281000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Transcriptomic responses of the calanoid copepod Calanus finmarchicus to the saxitoxin producing dinoflagellate Alexandrium fundyense"],"prefix":"10.1038","volume":"6","author":[{"given":"Vittoria","family":"Roncalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Cieslak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra H.","family":"Lenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,16]]},"reference":[{"key":"BFsrep25708_CR1","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1111\/j.1365-2486.2009.01848.x","volume":"15","author":"G Beaugrand","year":"2009","unstructured":"Beaugrand, G., Christophe, L. & Martin, E. 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