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Migrating birds catabolize substantial amounts of lean tissue during flight which may mobilize methylmercury and increase circulating levels of this neurotoxin. As a model for a migrating songbird, we fasted zebra finches (<jats:italic>Taeniopygia guttata<\/jats:italic>) that had been dosed with 0.0, 0.1, and 0.6 parts per million (ppm) dietary methylmercury and measured changes in blood total mercury concentrations (THg) in relation to reductions in lean mass. Birds lost 6\u201316% of their lean mass during the fast, and THg increased an average of 12% and 11% in the 0.1 and 0.6\u2009ppm treatments, respectively. Trace amounts of THg in the 0.0\u2009ppm control group also increased as a result of fasting, but remained extremely low. THg increased 0.4\u2009ppm for each gram of lean mass catabolized in the higher dose birds. Our findings indicate that methylmercury is mobilized from lean tissues during protein catabolism and results in acute increases in circulating concentrations. This is a previously undocumented potential threat to wild migratory birds, which may experience greater surges in circulating methylmercury than demonstrated here as a result of their greater reductions in lean mass.<\/jats:p>","DOI":"10.1038\/srep25762","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T10:30:48Z","timestamp":1463049048000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Mobilization of mercury from lean tissues during simulated migratory fasting in a model songbird"],"prefix":"10.1038","volume":"6","author":[{"given":"Chad L.","family":"Seewagen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Cristol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander R.","family":"Gerson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"BFsrep25762_CR1","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1126\/science.1154082","volume":"320","author":"DA Cristol","year":"2008","unstructured":"Cristol, D. 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