{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:13:03Z","timestamp":1787652783583,"version":"build-2736575974"},"reference-count":108,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Corrosion resistance, biocompatibility, improved osteointegration, as well the prevention of inflammation and pain are the most desired characteristics of hip replacement implants. In this study we introduce a novel multi-layered coating on AISI 316LVM stainless steel that shows promise with regard to all mentioned characteristics. The coating is prepared from alternating layers of the biocompatible polysaccharide chitosan and the non-steroid anti-inflammatory drug (NSAID), diclofenac. Electrochemical methods were employed to characterize the corrosion behavior of coated and uncoated samples in physiological solution. It is shown that these coatings improve corrosion resistance. It was also found that these coatings release the incorporated drug in controlled, multi-mechanism manner. Adding additional layers on top of the as-prepared samples, has potential for further tailoring of the release profile and increasing the drug dose. Biocompatibility was proven on human-derived osteoblasts in several experiments. Only viable cells were found on the sample surface after incubation of the samples with the same cell line. This novel coating could prove important for prolongation of the application potential of steel-based hip replacements, which are these days often replaced by more expensive ceramic or other metal alloys.<\/jats:p>","DOI":"10.1038\/srep26653","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T17:08:20Z","timestamp":1464109700000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Novel chitosan\/diclofenac coatings on medical grade stainless steel for hip replacement applications"],"prefix":"10.1038","volume":"6","author":[{"given":"Matja\u017e","family":"Fin\u0161gar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amra Perva","family":"Uzunali\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janja","family":"Stergar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidija","family":"Gradi\u0161nik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uro\u0161","family":"Maver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"BFsrep26653_CR1","unstructured":"Division, U. N. P. World Population Prospects: The 2015 Revision, Key Findings and Advance Tables (2015)."},{"key":"BFsrep26653_CR2","unstructured":"Union, O. E. Health at a Glance: Europe (OECD Publishing 2014)."},{"key":"BFsrep26653_CR3","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1016\/j.actbio.2014.01.004","volume":"10","author":"D Arcos","year":"2014","unstructured":"Arcos, D. et al. The relevance of biomaterials to the prevention and treatment of osteoporosis. Acta Biomaterialia 10, 1793\u20131805 (2014).","journal-title":"Acta Biomaterialia"},{"key":"BFsrep26653_CR4","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.apsusc.2013.10.029","volume":"288","author":"A Sharifnabi","year":"2014","unstructured":"Sharifnabi, A., Fathi, M. H., Yekta, B. E. & Hossainalipour, M. The structural and bio-corrosion barrier performance of Mg-substituted fluorapatite coating on 316L stainless steel human body implant. Applied Surface Science 288, 331\u2013340 (2014).","journal-title":"Applied Surface Science"},{"key":"BFsrep26653_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2014.11.004","volume":"13","author":"V Miguez-Pacheco","year":"2015","unstructured":"Miguez-Pacheco, V., Hench, L. L. & Boccaccini, A. R. Bioactive glasses beyond bone and teeth: Emerging applications in contact with soft tissues. Acta Biomaterialia 13, 1\u201315 (2015).","journal-title":"Acta Biomaterialia"},{"key":"BFsrep26653_CR6","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1166\/jbn.2013.1619","volume":"9","author":"E Salahinejad","year":"2013","unstructured":"Salahinejad, E. et al. Surface modification of stainless steel orthopedic implants by sol-gel ZrTiO4 and ZrTiO4-PMMA coatings. J Biomed Nanotechnol 9, 1327\u20131335 (2013).","journal-title":"J Biomed Nanotechnol"},{"key":"BFsrep26653_CR7","first-page":"463","volume":"25","author":"B Krecisz","year":"2012","unstructured":"Krecisz, B., Kiec-Swierczynska, M. & Chomiczewska-Skora, D. Allergy to orthopedic metal implants - a prospective study. Int J Occup Med Environ Health 25, 463\u2013469 (2012).","journal-title":"Int J Occup Med Environ Health"},{"key":"BFsrep26653_CR8","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s10047-011-0584-6","volume":"15","author":"Y Okazaki","year":"2012","unstructured":"Okazaki, Y. Development trends of custom-made orthopedic implants. J Artif Organs 15, 20\u201325 (2012).","journal-title":"J Artif Organs"},{"key":"BFsrep26653_CR9","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.actbio.2007.11.005","volume":"4","author":"C Wu","year":"2008","unstructured":"Wu, C. et al. Novel sphene coatings on Ti-6Al-4V for orthopedic implants using sol-gel method. Acta Biomater 4, 569\u2013576 (2008).","journal-title":"Acta Biomater"},{"key":"BFsrep26653_CR10","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.ijbiomac.2016.02.035","volume":"87","author":"A Rafique","year":"2016","unstructured":"Rafique, A., Mahmood Zia, K., Zuber, M., Tabasum, S. & Rehman, S. Chitosan functionalized poly(vinyl alcohol) for prospects biomedical and industrial applications: A review. Int J Biol Macromol 87, 141\u2013154 (2016).","journal-title":"Int J Biol Macromol"},{"key":"BFsrep26653_CR11","doi-asserted-by":"publisher","first-page":"6379","DOI":"10.1021\/acsami.6b00739","volume":"8","author":"WA Sarhan","year":"2016","unstructured":"Sarhan, W. A., Azzazy, H. M. & El-Sherbiny, I. Honey\/Chitosan Nanofiber Wound Dressing Enriched with Allium sativum and Cleome droserifolia: Enhanced Antimicrobial and Wound Healing Activity. ACS Appl Mater Interfaces 8, 6379\u20136390 (2016).","journal-title":"ACS Appl Mater Interfaces"},{"key":"BFsrep26653_CR12","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.ijbiomac.2015.01.049","volume":"75","author":"X Huang","year":"2015","unstructured":"Huang, X. et al. Using absorbable chitosan hemostatic sponges as a promising surgical dressing. Int J Biol Macromol 75, 322\u2013329 (2015).","journal-title":"Int J Biol Macromol"},{"key":"BFsrep26653_CR13","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.actbio.2015.08.043","volume":"27","author":"JH Ryu","year":"2015","unstructured":"Ryu, J. H., Hong, S. & Lee, H. Bio-inspired adhesive catechol-conjugated chitosan for biomedical applications: A mini review. Acta Biomater 27, 101\u2013115 (2015).","journal-title":"Acta Biomater"},{"key":"BFsrep26653_CR14","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.ijbiomac.2016.01.003","volume":"85","author":"I Kavianinia","year":"2016","unstructured":"Kavianinia, I. et al. Design and evaluation of a novel chitosan-based system for colon-specific drug delivery. Int J Biol Macromol 85, 539\u2013546 (2016).","journal-title":"Int J Biol Macromol"},{"key":"BFsrep26653_CR15","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.ijpharm.2015.08.056","volume":"495","author":"M Xue","year":"2015","unstructured":"Xue, M. et al. Development of chitosan nanoparticles as drug delivery system for a prototype capsid inhibitor. Int J Pharm 495, 771\u2013782 (2015).","journal-title":"Int J Pharm"},{"key":"BFsrep26653_CR16","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2174\/1567201812666150114155948","volume":"12","author":"L Cheng","year":"2015","unstructured":"Cheng, L., Bulmer, C. & Margaritis, A. Characterization of novel composite alginate chitosan-carrageenan nanoparticles for encapsulation of BSA as a model drug delivery system. Curr Drug Deliv 12, 351\u2013357 (2015).","journal-title":"Curr Drug Deliv"},{"key":"BFsrep26653_CR17","doi-asserted-by":"publisher","first-page":"821279","DOI":"10.1155\/2015\/821279","volume":"2015","author":"M Rodriguez-Vazquez","year":"2015","unstructured":"Rodriguez-Vazquez, M., Vega-Ruiz, B., Ramos-Zuniga, R., Saldana-Koppel, D. A. & Quinones-Olvera, L. F. Chitosan and Its Potential Use as a Scaffold for Tissue Engineering in Regenerative Medicine. Biomed Res Int 2015, 821279 (2015).","journal-title":"Biomed Res Int"},{"key":"BFsrep26653_CR18","doi-asserted-by":"publisher","first-page":"7263","DOI":"10.3892\/mmr.2015.4371","volume":"12","author":"L Chen","year":"2015","unstructured":"Chen, L. et al. Preparation and evaluation of an Arg-Gly-Asp-modified chitosan\/hydroxyapatite scaffold for application in bone tissue engineering. Mol Med Rep 12, 7263\u20137270 (2015).","journal-title":"Mol Med Rep"},{"key":"BFsrep26653_CR19","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.ijbiomac.2015.07.012","volume":"80","author":"A Shavandi","year":"2015","unstructured":"Shavandi, A., Bekhit Ael, D., Ali, M. A. & Sun, Z. Bio-mimetic composite scaffold from mussel shells, squid pen and crab chitosan for bone tissue engineering. Int J Biol Macromol 80, 445\u2013454 (2015).","journal-title":"Int J Biol Macromol"},{"key":"BFsrep26653_CR20","first-page":"63","volume":"24","author":"V Brun","year":"2014","unstructured":"Brun, V. et al. Chitosan\/hydroxyapatite hybrid scaffold for bone tissue engineering. Biomed Mater Eng 24, 63\u201373 (2014).","journal-title":"Biomed Mater Eng"},{"key":"BFsrep26653_CR21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/09205063.2013.836950","volume":"25","author":"J Zhang","year":"2014","unstructured":"Zhang, J. et al. Preparation and characterization of bionic bone structure chitosan\/hydroxyapatite scaffold for bone tissue engineering. J Biomater Sci Polym Ed 25, 61\u201374 (2014).","journal-title":"J Biomater Sci Polym Ed"},{"key":"BFsrep26653_CR22","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.ijbiomac.2015.04.078","volume":"79","author":"RA Farghali","year":"2015","unstructured":"Farghali, R. A., Fekry, A. M., Ahmed, R. A. & Elhakim, H. K. Corrosion resistance of Ti modified by chitosan-gold nanoparticles for orthopedic implantation. Int J Biol Macromol 79, 787\u2013799 (2015).","journal-title":"Int J Biol Macromol"},{"key":"BFsrep26653_CR23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.msec.2015.01.020","volume":"49","author":"Z Zhong","year":"2015","unstructured":"Zhong, Z., Qin, J. & Ma, J. Cellulose acetate\/hydroxyapatite\/chitosan coatings for improved corrosion resistance and bioactivity. Mater Sci Eng C Mater Biol Appl 49, 251\u2013255 (2015).","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"BFsrep26653_CR24","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.carbpol.2014.07.064","volume":"115","author":"AY Escobedo-Lozano","year":"2015","unstructured":"Escobedo-Lozano, A. Y., Domard, A., Vel\u00e1zquez, C. A., Goycoolea, F. M. & Arg\u00fcelles-Monal, W. M. Physical properties and antibacterial activity of chitosan\/acemannan mixed systems. Carbohydrate Polymers 115, 707\u2013714 (2015).","journal-title":"Carbohydrate Polymers"},{"key":"BFsrep26653_CR25","doi-asserted-by":"crossref","unstructured":"Zivanovic, S., Davis, R. H. & Golden, D. A. In Handbook of Natural Antimicrobials for Food Safety and Quality (ed Taylor, T. M. ) 153\u2013181 (Woodhead Publishing, 2015).","DOI":"10.1016\/B978-1-78242-034-7.00008-6"},{"key":"BFsrep26653_CR26","doi-asserted-by":"crossref","unstructured":"Jiang, T., James, R., Kumbar, S. G. & Laurencin, C. T. In Natural and Synthetic Biomedical Polymers (ed Sangamesh, G., KumbarCato, T., LaurencinMeng, Deng ) 91\u2013113 (Elsevier, 2014).","DOI":"10.1016\/B978-0-12-396983-5.00005-3"},{"key":"BFsrep26653_CR27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13643-016-0189-5","volume":"5","author":"EM Marques","year":"2016","unstructured":"Marques, E. M. et al. The choice between hip prosthetic bearing surfaces in total hip replacement: a protocol for a systematic review and network meta-analysis. Syst Rev 5, 19 (2016).","journal-title":"Syst Rev"},{"key":"BFsrep26653_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1302\/2046-3758.36.2000239","volume":"3","author":"JR Berstock","year":"2014","unstructured":"Berstock, J. R., Beswick, A. D., Lenguerrand, E., Whitehouse, M. R. & Blom, A. W. Mortality after total hip replacement surgery: A systematic review. Bone Joint Res 3, 175\u2013182 (2014).","journal-title":"Bone Joint Res"},{"key":"BFsrep26653_CR29","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.joca.2013.12.006","volume":"22","author":"L Shan","year":"2014","unstructured":"Shan, L., Shan, B., Graham, D. & Saxena, A. Total hip replacement: a systematic review and meta-analysis on mid-term quality of life. Osteoarthr Cartilage 22, 389\u2013406 (2014).","journal-title":"Osteoarthr Cartilage"},{"key":"BFsrep26653_CR30","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1302\/0301-620X.95B7.26931","volume":"95-B","author":"R Kallala","year":"2013","unstructured":"Kallala, R., Anderson, P., Morris, S. & Haddad, F. S. The cost analysis of cemented versus cementless total hip replacement operations on the NHS. Bone Joint J 95-B, 874\u2013876 (2013).","journal-title":"Bone Joint J"},{"key":"BFsrep26653_CR31","doi-asserted-by":"publisher","first-page":"888","DOI":"10.3111\/13696998.2013.802695","volume":"16","author":"CM Kozma","year":"2013","unstructured":"Kozma, C. M., Slaton, T., Paris, A. & Edgell, E. T. Cost and utilization of healthcare services for hip and knee replacement. J Med Econ 16, 888\u2013896 (2013).","journal-title":"J Med Econ"},{"key":"BFsrep26653_CR32","doi-asserted-by":"publisher","first-page":"f1026","DOI":"10.1136\/bmj.f1026","volume":"346","author":"M Pennington","year":"2013","unstructured":"Pennington, M. et al. Cemented, cementless and hybrid prostheses for total hip replacement: cost effectiveness analysis. BMJ 346, f1026 (2013).","journal-title":"BMJ"},{"key":"BFsrep26653_CR33","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jmbbm.2015.05.020","volume":"49","author":"A Ataollahi Oshkour","year":"2015","unstructured":"Ataollahi Oshkour, A. et al. Mechanical and physical behavior of newly developed functionally graded materials and composites of stainless steel 316L with calcium silicate and hydroxyapatite. J Mech Behav Biomed Mater 49, 321\u2013331 (2015).","journal-title":"J Mech Behav Biomed Mater"},{"key":"BFsrep26653_CR34","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s10856-015-5399-1","volume":"26","author":"S Ghaith el","year":"2015","unstructured":"Ghaith el, S., Hodgson, S. & Sharp, M. Laser surface alloying of 316L stainless steel coated with a bioactive hydroxyapatite-titanium oxide composite. J Mater Sci Mater Med 26, 83 (2015).","journal-title":"J Mater Sci Mater Med"},{"key":"BFsrep26653_CR35","doi-asserted-by":"publisher","first-page":"4046","DOI":"10.1016\/j.msec.2013.05.047","volume":"33","author":"S Sutha","year":"2013","unstructured":"Sutha, S., Kavitha, K., Karunakaran, G. & Rajendran, V. In-vitro bioactivity, biocorrosion and antibacterial activity of silicon integrated hydroxyapatite\/chitosan composite coating on 316 L stainless steel implants. Mater Sci Eng C Mater Biol Appl 33, 4046\u20134054 (2013).","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"BFsrep26653_CR36","doi-asserted-by":"publisher","first-page":"4594","DOI":"10.1016\/j.msec.2013.07.015","volume":"33","author":"VK Balla","year":"2013","unstructured":"Balla, V. K., Das, M., Bose, S., Ram, G. D. & Manna, I. Laser surface modification of 316 L stainless steel with bioactive hydroxyapatite. Mater Sci Eng C Mater Biol Appl 33, 4594\u20134598 (2013).","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"BFsrep26653_CR37","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1016\/j.msec.2013.02.038","volume":"33","author":"K Kato","year":"2013","unstructured":"Kato, K. et al. Cytocompatibility and mechanical properties of novel porous 316 L stainless steel. Mater Sci Eng C Mater Biol Appl 33, 2736\u20132743 (2013).","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"BFsrep26653_CR38","doi-asserted-by":"crossref","unstructured":"Roberts, N., Mujica-Mota, R. & Williams, D. The Cost of Improving Hip Replacement Follow-Up in the UK. Musculoskeletal Care (2015), doi: 10.1002\/msc.1117.","DOI":"10.1002\/msc.1117"},{"key":"BFsrep26653_CR39","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1001\/jamainternmed.2013.465","volume":"173","author":"A Steinmetz","year":"2013","unstructured":"Steinmetz, A. & Emanuel, E. J. What does a hip replacement cost?: the transparency imperative in 2013. Comment on \u201cObtaining consumer prices from US hospitals for a common surgical procedure\u201d. JAMA Intern Med 173, 432\u2013434 (2013).","journal-title":"JAMA Intern Med"},{"key":"BFsrep26653_CR40","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.jcis.2013.11.062","volume":"417","author":"X Hu","year":"2014","unstructured":"Hu, X., Neoh, K. G., Zhang, J. & Kang, E. T. Bacterial and osteoblast behavior on titanium, cobalt-chromium alloy and stainless steel treated with alkali and heat: a comparative study for potential orthopedic applications. J Colloid Interface Sci 417, 410\u2013419 (2014).","journal-title":"J Colloid Interface Sci"},{"key":"BFsrep26653_CR41","doi-asserted-by":"publisher","first-page":"e61633","DOI":"10.1371\/journal.pone.0061633","volume":"8","author":"E Salahinejad","year":"2013","unstructured":"Salahinejad, E. et al. In vitro electrochemical corrosion and cell viability studies on nickel-free stainless steel orthopedic implants. PLos One 8, e61633 (2013).","journal-title":"PLos One"},{"key":"BFsrep26653_CR42","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1007\/s00264-015-2894-4","volume":"39","author":"DA Fitch","year":"2015","unstructured":"Fitch, D. A., Ancarani, C. & Bordini, B. Long-term survivorship and complication rate comparison of a cementless modular stem and cementless fixed neck stems for primary total hip replacement. Int Orthop 39, 1827\u20131832 (2015).","journal-title":"Int Orthop"},{"key":"BFsrep26653_CR43","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1024\/1661-8157\/a001853","volume":"103","author":"M Attinger","year":"2014","unstructured":"Attinger, M. & Siebenrock, K. [Total hip replacement: between normal rehabilitation and complication]. Praxis (Bern 1994) 103, 1439\u20131446 (2014).","journal-title":"Praxis (Bern 1994)"},{"key":"BFsrep26653_CR44","first-page":"53","volume":"75","author":"M Drobniewski","year":"2010","unstructured":"Drobniewski, M., Sibinski, M., Plebanski, R. & Synder, M. [Breakage of the prosthesis steam as a rare complication of total hip replacement]. Chir Narzadow Ruchu Ortop Pol 75, 53\u201356 (2010).","journal-title":"Chir Narzadow Ruchu Ortop Pol"},{"key":"BFsrep26653_CR45","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.jmbbm.2014.08.021","volume":"40","author":"M Bryant","year":"2014","unstructured":"Bryant, M. et al. Galvanically enhanced fretting-crevice corrosion of cemented femoral stems. J Mech Behav Biomed Mater 40, 275\u2013286 (2014).","journal-title":"J Mech Behav Biomed Mater"},{"key":"BFsrep26653_CR46","doi-asserted-by":"publisher","first-page":"327","DOI":"10.5301\/hipint.5000139","volume":"24","author":"MJ Le Duff","year":"2014","unstructured":"Le Duff, M. J., Johnson, A. J. & Amstutz, H. C. Do hardened femoral heads reduce blood metal ion concentrations after hip resurfacing? Hip Int 24, 327\u2013332 (2014).","journal-title":"Hip Int"},{"key":"BFsrep26653_CR47","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1007\/s11999-013-2981-z","volume":"471","author":"L Savarino","year":"2013","unstructured":"Savarino, L., Cadossi, M., Chiarello, E., Baldini, N. & Giannini, S. Do ion levels in metal-on-metal hip resurfacing differ from those in metal-on-metal THA at long-term followup? Clin Orthop Relat Res 471, 2964\u20132971 (2013).","journal-title":"Clin Orthop Relat Res"},{"key":"BFsrep26653_CR48","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1177\/0300060513476583","volume":"41","author":"Y Zeng","year":"2013","unstructured":"Zeng, Y. & Feng, W. Metal allergy in patients with total hip replacement: a review. J Int Med Res 41, 247\u2013252 (2013).","journal-title":"J Int Med Res"},{"key":"BFsrep26653_CR49","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.mspro.2012.06.060","volume":"1","author":"MD Pereda","year":"2012","unstructured":"Pereda, M. D. et al. Impact of Surface Treatment on the Corrosion Resistance of ASTM F138-F139 Stainless Steel for Biomedical Applications. Procedia Materials Science 1, 446\u2013453 (2012).","journal-title":"Procedia Materials Science"},{"key":"BFsrep26653_CR50","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.jbiomech.2014.11.035","volume":"48","author":"V Saikko","year":"2015","unstructured":"Saikko, V. High frequency circular translation pin-on-disk method for accelerated wear testing of ultrahigh molecular weight polyethylene as a bearing material in total hip arthroplasty. J Biomech 48, 401\u2013404 (2015).","journal-title":"J Biomech"},{"key":"BFsrep26653_CR51","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1007\/s11999-012-2396-2","volume":"470","author":"T Kadar","year":"2012","unstructured":"Kadar, T., Dybvik, E., Hallan, G., Furnes, O. & Havelin, L. I. Head material influences survival of a cemented total hip prosthesis in the Norwegian Arthroplasty Register. Clin Orthop Relat Res 470, 3007\u20133013 (2012).","journal-title":"Clin Orthop Relat Res"},{"key":"BFsrep26653_CR52","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1080\/10255840802546754","volume":"12","author":"J Folgado","year":"2009","unstructured":"Folgado, J., Fernandes, P. R., Jacobs, C. R. & Pellegrini, V. D., Jr. Influence of femoral stem geometry, material and extent of porous coating on bone ingrowth and atrophy in cementless total hip arthroplasty: an iterative finite element model. Comput Methods Biomech Biomed Engin 12, 135\u2013145 (2009).","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"BFsrep26653_CR53","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cps.2011.09.005","volume":"39","author":"EA Gantwerker","year":"2012","unstructured":"Gantwerker, E. A. & Hom, D. B. Skin: histology and physiology of wound healing. Clin Plast Surg 39, 85\u201397 (2012).","journal-title":"Clin Plast Surg"},{"key":"BFsrep26653_CR54","first-page":"72","volume":"55","author":"S Petrulyte","year":"2008","unstructured":"Petrulyte, S. Advanced textile materials and biopolymers in wound management. Dan Med Bull 55, 72\u201377 (2008).","journal-title":"Dan Med Bull"},{"key":"BFsrep26653_CR55","doi-asserted-by":"publisher","first-page":"110","DOI":"10.12968\/jowc.2010.19.3.47280","volume":"19","author":"K Solowiej","year":"2010","unstructured":"Solowiej, K., Mason, V. & Upton, D. Psychological stress and pain in wound care, part 2: a review of pain and stress assessment tools. J Wound Care 19, 110\u2013115 (2010).","journal-title":"J Wound Care"},{"key":"BFsrep26653_CR56","first-page":"50","volume":"2","author":"GV Korshunov","year":"2012","unstructured":"Korshunov, G. V., Puchin\u2019ian, D. M. & Shakhmartova, S. G. The molecular markers of systemic inflammation response and hemocoagulation in case of endoprosthesis replacement of articulation of hip. Klin Lab Diagn 2, 50\u201352 (2012).","journal-title":"Klin Lab Diagn"},{"key":"BFsrep26653_CR57","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.2106\/JBJS.K.00625","volume":"93","author":"P Manner","year":"2011","unstructured":"Manner, P. Good start on using biochemical markers to compare surgical trauma in total hip replacement approaches: commentary on an article by Patrick F. Bergin, MD, et al.: \u201cComparison of minimally invasive direct anterior versus posterior total hip arthroplasty based on inflammation and muscle damage markers\u201d. J Bone Joint Surg Am 93, e89 (2011).","journal-title":"J Bone Joint Surg Am"},{"key":"BFsrep26653_CR58","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s10570-014-0515-9","volume":"22","author":"T Maver","year":"2015","unstructured":"Maver, T. et al. Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials. Cellulose 22, 749\u2013761 (2015).","journal-title":"Cellulose"},{"key":"BFsrep26653_CR59","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1111\/pme.12288","volume":"14","author":"ML McPherson","year":"2013","unstructured":"McPherson, M. L. & Cimino, N. M. Topical NSAID formulations. Pain Med 14 Suppl 1, S35\u201339 (2013).","journal-title":"Pain Med"},{"key":"BFsrep26653_CR60","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.2174\/0929867311320140004","volume":"20","author":"C Puglia","year":"2013","unstructured":"Puglia, C., Tirendi, G. G. & Bonina, F. Emerging role of colloidal drug delivery systems (CDDS) in NSAID topical administration. Curr Med Chem 20, 1847\u20131857 (2013).","journal-title":"Curr Med Chem"},{"key":"BFsrep26653_CR61","doi-asserted-by":"publisher","first-page":"77873","DOI":"10.1039\/C5RA11972C","volume":"5","author":"T Maver","year":"2015","unstructured":"Maver, T. et al. Functional wound dressing materials with highly tunable drug release properties. RSC Advances 5, 77873\u201377884 (2015).","journal-title":"RSC Advances"},{"key":"BFsrep26653_CR62","doi-asserted-by":"crossref","unstructured":"Fin\u0161gar, M. & Jackson, J. The corrosion resistance of 2205 duplex steel in non-inhibited methanesulphonic acid at elevated temperature. Mater Corros, 10.1002\/maco.201408222 (2015).","DOI":"10.1002\/maco.201408222"},{"key":"BFsrep26653_CR63","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.corsci.2014.02.016","volume":"83","author":"M Fin\u0161gar","year":"2014","unstructured":"Fin\u0161gar, M. & Kek Merl, D. An Electrochemical, Long-term Immersion and XPS Study of 2-Mercaptobenzothiazole as a Copper Corrosion Inhibitor in Chloride Solution. Corros. Sci. 83, 164\u2013175 (2014).","journal-title":"Corros. Sci."},{"key":"BFsrep26653_CR64","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.colsurfb.2014.09.053","volume":"123","author":"T Mohan","year":"2014","unstructured":"Mohan, T. et al. Interaction and enrichment of protein on cationic polysaccharide surfaces. Colloids Surf B Biointerfaces 123, 533\u2013541 (2014).","journal-title":"Colloids Surf B Biointerfaces"},{"key":"BFsrep26653_CR65","doi-asserted-by":"crossref","unstructured":"Horcas, I. et al. WSXM: A software for scanning probe microscopy and a tool for nanotechnology. Rev Sci Instrum 78 (2007).","DOI":"10.1063\/1.2432410"},{"key":"BFsrep26653_CR66","unstructured":"Massart, D. L. et al. Handbook of Chemometrics and Qualimetrics: Part A. (Elsevir, 1997)."},{"key":"BFsrep26653_CR67","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3109\/17453679908997826","volume":"70","author":"KB Jonsson","year":"1999","unstructured":"Jonsson, K. B., Frost, A., Nilsson, O., Ljunghall, S. & Ljunggren, O. Three isolation techniques for primary culture of human osteoblast-like cells: a comparison. Acta Orthop Scand 70, 365\u2013373 (1999).","journal-title":"Acta Orthop Scand"},{"key":"BFsrep26653_CR68","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/0022-1759(94)90034-5","volume":"174","author":"AA van de Loosdrecht","year":"1994","unstructured":"van de Loosdrecht, A. A., Beelen, R. H., Ossenkoppele, G. J., Broekhoven, M. G. & Langenhuijsen, M. M. A tetrazolium-based colorimetric MTT assay to quantitate human monocyte mediated cytotoxicity against leukemic cells from cell lines and patients with acute myeloid leukemia. J Immunol Methods 174, 311\u2013320 (1994).","journal-title":"J Immunol Methods"},{"key":"BFsrep26653_CR69","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0022-1759(90)90187-Z","volume":"131","author":"M Ferrari","year":"1990","unstructured":"Ferrari, M., Fornasiero, M. C. & Isetta, A. M. MTT colorimetric assay for testing macrophage cytotoxic activity in vitro. J Immunol Methods 131, 165\u2013172 (1990).","journal-title":"J Immunol Methods"},{"key":"BFsrep26653_CR70","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65, 55\u201363 (1983).","journal-title":"J Immunol Methods"},{"key":"BFsrep26653_CR71","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1039\/c3tb00498h","volume":"1","author":"HS Mansur","year":"2013","unstructured":"Mansur, H. S., Mansur, A. A. P., Curti, E. & De Almeida, M. V. Functionalized-chitosan\/quantum dot nano-hybrids for nanomedicine applications: towards biolabeling and biosorbing phosphate metabolites. J Mater Chem B 1, 1696\u20131711 (2013).","journal-title":"J Mater Chem B"},{"key":"BFsrep26653_CR72","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s10570-014-0515-9","volume":"22","author":"T Maver","year":"2015","unstructured":"Maver, T. et al. Cellulose based thin films as a platform for drug release studies to mimick wound dressing materials. Cellulose 22, 749\u2013761 (2015).","journal-title":"Cellulose"},{"key":"BFsrep26653_CR73","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.amc.2013.07.071","volume":"223","author":"V Cregan","year":"2013","unstructured":"Cregan, V. & O\u2019Brien, S. B. G. Extended asymptotic solutions to the spin-coating model with small evaporation. Appl Math Comput 223, 76\u201387 (2013).","journal-title":"Appl Math Comput"},{"key":"BFsrep26653_CR74","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1039\/c3ay26476a","volume":"5","author":"EP Randviir","year":"2013","unstructured":"Randviir, E. P. & Banks, C. E. Electrochemical impedance spectroscopy: an overview of bioanalytical applications. Aanal Method 5, 1098\u20131115 (2013).","journal-title":"Aanal Method"},{"key":"BFsrep26653_CR75","unstructured":"Raistrick, I. D., Franceschetti, D. R. & Macdonald, J. R. Impedance Spectroscopy Theory, Experiment and Application, 2nd Edition. (John Wiley&Sons, Inc., Hoboken, 2005)."},{"key":"BFsrep26653_CR76","doi-asserted-by":"publisher","first-page":"J15","DOI":"10.1149\/1.2165778","volume":"153","author":"D Kek-Merl","year":"2006","unstructured":"Kek-Merl, D., Lappalainen, J. & Tuller, H. L. Electrical properties of nanocrystalline CeO2 thin films deposited by in situ pulsed laser deposition. Journal of the Electrochemical Society 153, J15\u2013J20 (2006).","journal-title":"Journal of the Electrochemical Society"},{"key":"BFsrep26653_CR77","unstructured":"ASTM F 2129\u201308, Standard Test Method for Conducting Cyclic Potentiodynamic Polarization Measurements to Determine the Corrosion Susceptibility of Small Implant Devices, ASTM International, West Conshohocken, PA, www.astm.org (2008)."},{"key":"BFsrep26653_CR78","doi-asserted-by":"publisher","first-page":"734","DOI":"10.5006\/1.3315994","volume":"48","author":"EM Rosen","year":"1992","unstructured":"Rosen, E. M. & Silverman, D. C. Corrosion Prediction from Polarization Scans Using an Artificial Neural Network Integrated with an Expert System. Corrosion 48, 734\u2013745 (1992).","journal-title":"Corrosion"},{"key":"BFsrep26653_CR79","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1016\/j.corsci.2010.04.001","volume":"52","author":"M Fin\u0161gar","year":"2010","unstructured":"Fin\u0161gar, M. & Milo\u0161ev, I. Corrosion behaviour of stainless steels in aqueous solutions of methanesulfonic acid. Corros. Sci. 52, 2430\u20132438 (2010).","journal-title":"Corros. Sci."},{"key":"BFsrep26653_CR80","doi-asserted-by":"publisher","first-page":"283","DOI":"10.5006\/0010-9312-28.8.283","volume":"28","author":"BE Wilde","year":"1972","unstructured":"Wilde, B. E. A Critical Appraisal of Some Popular Laboratory Electrochemical Tests for Predicting the Localized Corrosion Resistance of Stainless Alloys in Sea Water. Corrosion 28, 283\u2013291 (1972).","journal-title":"Corrosion"},{"key":"BFsrep26653_CR81","first-page":"1179","volume":"68","author":"DC Silverman","year":"2000","unstructured":"Silverman, D. C. In Uhlig Corrosion Handbook (ed Revie, R. W. ) Ch. 68, 1179\u20131225 (John Wiley and Sons, 2000).","journal-title":"Uhlig Corrosion Handbook"},{"key":"BFsrep26653_CR82","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.corsci.2008.12.006","volume":"51","author":"M Fin\u0161gar","year":"2009","unstructured":"Fin\u0161gar, M., Fassbender, S., Nicolini, F. & Milo\u0161ev, I. Polyethyleneimine as a corrosion inhibitor for ASTM 420 stainless steel in near-neutral saline media. Corros. Sci. 51, 525\u2013533 (2009).","journal-title":"Corros. Sci."},{"key":"BFsrep26653_CR83","doi-asserted-by":"crossref","unstructured":"Burstein, G. T. In Shreir\u2019s Corrosion Vol. Volume 2: Corrosion in Liquids, Corrosion Evaluation (ed Richardson, Tony J.A. ) Ch. 2.02 \u2013 Passivity and Localized Corrosion, 731\u2013752 (Elsevier, 2010).","DOI":"10.1016\/B978-044452787-5.00198-0"},{"key":"BFsrep26653_CR84","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1093\/bja\/aet416","volume":"112","author":"G Imberger","year":"2014","unstructured":"Imberger, G. et al. Does anaesthesia with nitrous oxide affect mortality or cardiovascular morbidity? A systematic review with meta-analysis and trial sequential analysis. Br J Anaesth 112, 410\u2013426 (2014).","journal-title":"Br J Anaesth"},{"key":"BFsrep26653_CR85","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.ijoa.2011.07.005","volume":"20","author":"S Soltanifar","year":"2011","unstructured":"Soltanifar, S., Tunstill, S., Bhardwaj, M. & Russell, R. The incidence of postoperative morbidity following general anaesthesia for caesarean section. Int J Obstet Anesth 20, 365 (2011).","journal-title":"Int J Obstet Anesth"},{"key":"BFsrep26653_CR86","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.bpa.2011.02.008","volume":"25","author":"G Haller","year":"2011","unstructured":"Haller, G., Laroche, T. & Clergue, F. Morbidity in anaesthesia: today and tomorrow. Best Pract Res Clin Anaesthesiol 25, 123\u2013132 (2011).","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"BFsrep26653_CR87","doi-asserted-by":"publisher","first-page":"929","DOI":"10.2217\/fmb.15.27","volume":"10","author":"G Banche","year":"2015","unstructured":"Banche, G. et al. Antimicrobial chitosan nanodroplets: new insights for ultrasound-mediated adjuvant treatment of skin infection. Future Microbiol 10, 929\u2013939 (2015).","journal-title":"Future Microbiol"},{"key":"BFsrep26653_CR88","doi-asserted-by":"publisher","first-page":"7995","DOI":"10.3390\/ijms16047995","volume":"16","author":"SC Park","year":"2015","unstructured":"Park, S. C. et al. Antimicrobial action of water-soluble beta-chitosan against clinical multi-drug resistant bacteria. Int J Mol Sci 16, 7995\u20138007 (2015).","journal-title":"Int J Mol Sci"},{"key":"BFsrep26653_CR89","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1089\/mdr.2014.0117","volume":"21","author":"Y Deng","year":"2015","unstructured":"Deng, Y. et al. Antimicrobial resistance investigation on Staphylococcus strains in a local hospital in Guangzhou, China, 2001-2010. Microb Drug Resist 21, 102\u2013104 (2015).","journal-title":"Microb Drug Resist"},{"key":"BFsrep26653_CR90","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s10440-012-9683-5","volume":"118","author":"MC Delfour","year":"2012","unstructured":"Delfour, M. C. Drug Release Kinetics from Biodegradable Polymers via Partial Differential Equations Models. Acta Appl Math 118, 161\u2013183 (2012).","journal-title":"Acta Appl Math"},{"key":"BFsrep26653_CR91","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ijpharm.2010.12.009","volume":"418","author":"C Yin","year":"2011","unstructured":"Yin, C. & Li, X. C. Anomalous diffusion of drug release from a slab matrix: Fractional diffusion models. Int J Pharm 418, 78\u201387 (2011).","journal-title":"Int J Pharm"},{"key":"BFsrep26653_CR92","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1179\/175355510X12723642365566","volume":"25","author":"C Aguzzi","year":"2010","unstructured":"Aguzzi, C., Cerezo, P., Salcedo, I., Sanchez, R. & Viseras, C. Mathematical models describing drug release from biopolymeric delivery systems. Mater Technol 25, 205\u2013211 (2010).","journal-title":"Mater Technol"},{"key":"BFsrep26653_CR93","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.materresbull.2012.10.021","volume":"48","author":"U Maver","year":"2013","unstructured":"Maver, U., Bele, M., Jamnik, J., Gaber\u0161\u010dek, M. & Planin\u0161ek, O. A fast and simple method for preparation of calcium carbonate-drug composites for fast drug release. Materials Research Bulletin 48, 137\u2013145 (2013).","journal-title":"Materials Research Bulletin"},{"key":"BFsrep26653_CR94","doi-asserted-by":"publisher","first-page":"3908","DOI":"10.1021\/am400604d","volume":"5","author":"P Nadrah","year":"2013","unstructured":"Nadrah, P. et al. Hindered Disulfide Bonds to Regulate Release Rate of Model Drug from Mesoporous Silica. ACS Appl. Mater. Interfaces 5, 3908\u20133915 (2013).","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"BFsrep26653_CR95","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.matchemphys.2012.01.013","volume":"133","author":"K \u017du\u017eek Ro\u017eman","year":"2012","unstructured":"\u017du\u017eek Ro\u017eman, K. et al. Electrochemical synthesis and characterization of Fe 70Pd 30 nanotubes for drug-delivery applications. Mater Chem Phys 133, 218\u2013224 (2012).","journal-title":"Mater Chem Phys"},{"key":"BFsrep26653_CR96","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1039\/C1JM13493K","volume":"22","author":"T Ukmar","year":"2012","unstructured":"Ukmar, T. et al. Guest-host van der Waals interactions decisively affect the molecular transport in mesoporous media. J Mater Chem 22, 1112\u20131120 (2012).","journal-title":"J Mater Chem"},{"key":"BFsrep26653_CR97","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jconrel.2011.06.038","volume":"155","author":"T Ukmar","year":"2011","unstructured":"Ukmar, T. et al. Understanding controlled drug release from mesoporous silicates: Theory and experiment. J Control Release 155, 409\u2013417 (2011).","journal-title":"J Control Release"},{"key":"BFsrep26653_CR98","first-page":"309","volume":"20","author":"N Goyal","year":"2010","unstructured":"Goyal, N. & Hozack, W. J. Neck-modular femoral stems for total hip arthroplasty. Surg Technol Int 20, 309\u2013313 (2010).","journal-title":"Surg Technol Int"},{"key":"BFsrep26653_CR99","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1002\/jor.22461","volume":"31","author":"A Panagiotidou","year":"2013","unstructured":"Panagiotidou, A. et al. Enhanced wear and corrosion in modular tapers in total hip replacement is associated with the contact area and surface topography. J Orthop Res 31, 2032\u20132039 (2013).","journal-title":"J Orthop Res"},{"key":"BFsrep26653_CR100","first-page":"60","volume":"10","author":"S Fusi","year":"2009","unstructured":"Fusi, S., Paris, D., Dala Pria, P. & Bloch, H. R. & Pressacco, M. L\u2019evoluzione del disegno protesico dei colli modulari: lo stelo H-MAX M. Sphera Medical Journal 10, 60\u201363 (2009).","journal-title":"Sphera Medical Journal"},{"key":"BFsrep26653_CR101","unstructured":"Drugs.com. Diclofenac Information from Drugs.com, (2014) (Date of access: August 28, 2015), http:\/\/www.drugs.com\/pro\/diclofenac.html."},{"key":"BFsrep26653_CR102","first-page":"1","volume":"17","author":"CBSS Danoux","year":"2015","unstructured":"Danoux, C. B. S. S. et al. Elucidating the individual effects of calcium and phosphate ions on hMSCs by using composite materials. Acta Mater 17, 1\u201315 (2015).","journal-title":"Acta Mater"},{"key":"BFsrep26653_CR103","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.actbio.2014.10.021","volume":"12","author":"L-P Yan","year":"2015","unstructured":"Yan, L.-P. et al. Bilayered silk\/silk-nanoCaP scaffolds for osteochondral tissue engineering: In vitro and in vivo assessment of biological performance. Acta Biomater 12, 227\u2013241 (2015).","journal-title":"Acta Biomater"},{"key":"BFsrep26653_CR104","doi-asserted-by":"crossref","unstructured":"Uklejewski, R., Rogala, P., Winiecki, M., Kedzia, A. & Ruszkowski, P. Preliminary Results of Implantation in Animal Model and Osteoblast Culture Evaluation of Prototypes of Biomimetic Multispiked Connecting Scaffold for Noncemented Stemless Resurfacing Hip Arthroplasty Endoprostheses. Biomed Res Int (2013), doi: 10.1155\/2013\/689089.","DOI":"10.1155\/2013\/689089"},{"key":"BFsrep26653_CR105","first-page":"3949","volume":"9","author":"R Ma","year":"2014","unstructured":"Ma, R. et al. Preparation, characterization and in vitro osteoblast functions of a nano-hydroxyapatite\/polyetheretherketone biocomposite as orthopedic implant material. Int J Nanomedicine 9, 3949\u20133961 (2014).","journal-title":"Int J Nanomedicine"},{"key":"BFsrep26653_CR106","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.1016\/j.msec.2013.06.020","volume":"33","author":"A Gyorgyey","year":"2013","unstructured":"Gyorgyey, A. et al. Attachment and proliferation of human osteoblast-like cells (MG-63) on laser-ablated titanium implant material. Mater Sci Eng C Mater Biol Appl 33, 4251\u20134259 (2013).","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"BFsrep26653_CR107","doi-asserted-by":"publisher","first-page":"2636","DOI":"10.1002\/jbm.a.34937","volume":"102","author":"EM Czekanska","year":"2014","unstructured":"Czekanska, E. M., Stoddart, M. J., Ralphs, J. R., Richards, R. G. & Hayes, J. S. A phenotypic comparison of osteoblast cell lines versus human primary osteoblasts for biomaterials testing. J Biomed Mater Res A 102, 2636\u20132643 (2014).","journal-title":"J Biomed Mater Res A"},{"key":"BFsrep26653_CR108","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/adhm.201300265","volume":"3","author":"JM Silva","year":"2014","unstructured":"Silva, J. M. et al. Nanostructured Hollow Tubes Based on Chitosan and Alginate Multilayers. Adv Healthc Mater 3, 433\u2013440 (2014).","journal-title":"Adv Healthc Mater"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep26653","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep26653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep26653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T23:01:06Z","timestamp":1718578866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep26653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,24]]},"references-count":108,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,7,18]]}},"alternative-id":["BFsrep26653"],"URL":"https:\/\/doi.org\/10.1038\/srep26653","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,24]]},"assertion":[{"value":"6 December 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"26653"}}