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The present study aimed to investigate whether the tag single-nucleotide polymorphisms (tag SNPs) of these 5 protein-coding genes are associated with Beh\u00e7et\u2019s disease (BD). A two-stage association study was performed in a total of 907 BD patients and 1780 healthy controls. Altogether 32 polymorphisms were tested, using a Sequenom MassARRAY genotyping method in the first stage and a PCR-restriction fragment length polymorphism (PCR-RFLP) assay in the replication phase. Real-time PCR was performed to test the relative mRNA expression level of GAS6 and PROS1 from different SNP genotyped healthy individuals. The frequency of the C allele and CC genotype of rs9577873 in GAS6 (P<jats:sub>c<\/jats:sub>\u2009=\u20094.92\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>, P<jats:sub>c<\/jats:sub>\u2009=\u20091.91\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>, respectively) and A allele and AA genotype of rs4857037 in PROS1 (P<jats:sub>c<\/jats:sub>\u2009=\u20091.85\u2009\u00d7\u200910<jats:sup>\u22126<\/jats:sup>, P<jats:sub>c<\/jats:sub>\u2009=\u20094.52\u2009\u00d7\u200910<jats:sup>\u22127<\/jats:sup>, respectively) were significantly increased in BD. GAS6 expression in CC carriers of rs9577873 was significantly lower than that in CT\/TT individuals (P\u2009=\u20090.001). Decreased expression of GAS6 and increased pro-inflammatory cytokines (IL-6 and IFN-\u03b3: P\u2009=\u20094.23\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>, P\u2009=\u20090.011, respectively) in individuals carrying the CC genotype suggest that the TAM-GAS6\/PROS1 signal pathway may be involved in the pathogenesis of BD.<\/jats:p>","DOI":"10.1038\/srep26662","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T09:28:13Z","timestamp":1464168493000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of receptor tyrosine kinase genetics identifies two novel risk loci in GAS6 and PROS1 in Beh\u00e7et\u2019s disease"],"prefix":"10.1038","volume":"6","author":[{"given":"Jieying","family":"Qin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donglei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongsong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Handan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bolin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aize","family":"Kijlstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peizeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,5,25]]},"reference":[{"key":"BFsrep26662_CR1","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.ophtha.2007.04.056","volume":"115","author":"P Yang","year":"2008","unstructured":"Yang, P. et al. 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