{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T17:52:39Z","timestamp":1792432359487,"version":"4.5.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T00:00:00Z","timestamp":1464307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Parathyroidectomy (PTX) is an effective treatment for severe secondary hyperparathyroidism (SHPT); however, persistent SHPT may occur because of supernumerary and ectopic parathyroids. Here a diagnostic accuracy study of intraoperative and perioperative serum intact parathyroid hormone (iPTH) was performed to predict successful surgery in 501 patients, who received total PTX + autotransplantation without thymectomy. Serum iPTH values before incision (io-iPTH0), 10 and 20 min after removing the last parathyroid (io-iPTH10, io-iPTH20), and the first and fourth day after PTX (D1-iPTH, D4-iPTH) were recoded. Patients whose serum iPTH was &gt;50\u2009pg\/mL at the first postoperative week were followed up within six months. Successful PTX was defined if iPTH was &lt;300\u2009pg\/mL, on the contrary, persistent SHPT was regarded. There were 86.4% patients underwent successful PTX, 9.8% remained as persistent SHPT and 3.8% were undetermined. Intraoperative serum iPTH demonstrated no significant differences in two subgroups with or without chronic hepatitis. Receiver operating characteristic (ROC) curves showed that &gt;88.9% of io-iPTH20% could predict successful PTX (area under the curve [AUC] 0.909, sensitivity 78.6%, specificity 88.5%), thereby avoiding unnecessary exploration to reduce operative complications. D4-iPTH &gt;147.4\u2009pg\/mL could predict persistent SHPT (AUC 0.998, sensitivity 100%, specificity 99.5%), so that medical intervention or reoperation start timely.<\/jats:p>","DOI":"10.1038\/srep26841","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T09:21:25Z","timestamp":1464340885000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Diagnostic Accuracy Study of Intraoperative and Perioperative Serum Intact PTH Level for Successful Parathyroidectomy in 501 Secondary Hyperparathyroidism Patients"],"prefix":"10.1038","volume":"6","author":[{"given":"Lina","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changying","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,27]]},"reference":[{"key":"BFsrep26841_CR1","doi-asserted-by":"publisher","first-page":"913","DOI":"10.2215\/cjn.06040710","volume":"6","author":"J Cunningham","year":"2011","unstructured":"Cunningham, J., Locatelli, F. & Rodriguez, M. Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options. Clinical journal of the American Society of Nephrology: CJASN 6, 913\u2013921, 10.2215\/cjn.06040710 (2011).","journal-title":"Clinical journal of the American Society of Nephrology: CJASN"},{"key":"BFsrep26841_CR2","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Work Group clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney international. Supplement, S1\u2013130, 10.1038\/ki.2009.188 (2009)."},{"key":"BFsrep26841_CR3","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s00268-011-1392-0","volume":"36","author":"R Schneider","year":"2012","unstructured":"Schneider, R., Slater, E. P., Karakas, E., Bartsch, D. K. & Schlosser, K. Initial parathyroid surgery in 606 patients with renal hyperparathyroidism. World journal of surgery 36, 318\u2013326, 10.1007\/s00268-011-1392-0 (2012).","journal-title":"World journal of surgery"},{"key":"BFsrep26841_CR4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3275\/7621","volume":"35","author":"G Conzo","year":"2012","unstructured":"Conzo, G. et al. Total parathyroidectomy without autotransplantation in the surgical treatment of secondary hyperparathyroidism of chronic kidney disease. Journal of endocrinological investigation 35, 8\u201313, 10.3275\/7621 (2012).","journal-title":"Journal of endocrinological investigation"},{"key":"BFsrep26841_CR5","doi-asserted-by":"publisher","first-page":"c102","DOI":"10.1159\/000191200","volume":"111","author":"S Stracke","year":"2009","unstructured":"Stracke, S., Keller, F., Steinbach, G., Henne-Bruns, D. & Wuerl, P. Long-term outcome after total parathyroidectomy for the management of secondary hyperparathyroidism. Nephron. Clinical practice 111, c102\u2013109, 10.1159\/000191200 (2009).","journal-title":"Nephron. Clinical practice"},{"key":"BFsrep26841_CR6","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1172\/JCI110106","volume":"67","author":"KA Hruska","year":"1981","unstructured":"Hruska, K. A., Korkor, A., Martin, K. & Slatopolsky, E. Peripheral metabolism of intact parathyroid hormone. Role of liver and kidney and the effect of chronic renal failure. The Journal of clinical investigation 67, 885\u2013892 (1981).","journal-title":"The Journal of clinical investigation"},{"key":"BFsrep26841_CR7","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1210\/jcem-71-6-1561","volume":"71","author":"W Kirch","year":"1990","unstructured":"Kirch, W., Hofig, M., Ledendecker, T. & Schmidt-Gayk, H. Parathyroid hormone and cirrhosis of the liver. The Journal of clinical endocrinology and metabolism 71, 1561\u20131566, 10.1210\/jcem-71-6-1561 (1990).","journal-title":"The Journal of clinical endocrinology and metabolism"},{"key":"BFsrep26841_CR8","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1373\/clinchem.2005.065490","volume":"52","author":"C Bieglmayer","year":"2006","unstructured":"Bieglmayer, C., Kaczirek, K., Prager, G. & Niederle, B. Parathyroid hormone monitoring during total parathyroidectomy for renal hyperparathyroidism: pilot study of the impact of renal function and assay specificity. Clin Chem 52, 1112\u20131119, 10.1373\/clinchem.2005.065490 (2006).","journal-title":"Clin Chem"},{"key":"BFsrep26841_CR9","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1053\/j.ajkd.2011.08.009","volume":"58","author":"RN Moorthi","year":"2011","unstructured":"Moorthi, R. N. & Moe, S. M. CKD-mineral and bone disorder: core curriculum 2011. American journal of kidney diseases: the official journal of the National Kidney Foundation 58, 1022\u20131036, 10.1053\/j.ajkd.2011.08.009 (2011).","journal-title":"American journal of kidney diseases: the official journal of the National Kidney Foundation"},{"key":"BFsrep26841_CR10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1530\/eje.0.1490301","volume":"149","author":"H Yamashita","year":"2003","unstructured":"Yamashita, H. et al. Large carboxy-terminal parathyroid hormone (PTH) fragment with a relatively longer half-life than 1\u201384 PTH is secreted directly from the parathyroid gland in humans. European journal of endocrinology \/ European Federation of Endocrine Societies 149, 301\u2013306 (2003).","journal-title":"European journal of endocrinology \/ European Federation of Endocrine Societies"},{"key":"BFsrep26841_CR11","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1067\/msy.2000.110431","volume":"128","author":"J Lokey","year":"2000","unstructured":"Lokey, J. et al. Intraoperative decay profile of intact (1\u201384) parathyroid hormone in surgery for renal hyperparathyroidism\u2013a consecutive series of 80 patients. Surgery 128, 1029\u20131034, 10.1067\/msy.2000.110431 (2000).","journal-title":"Surgery"},{"key":"BFsrep26841_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4174\/jkss.2012.83.1.1","volume":"83","author":"WY Kim","year":"2012","unstructured":"Kim, W. Y., Lee, J. B. & Kim, H. Y. Efficacy of intraoperative parathyroid hormone monitoring to predict success of parathyroidectomy for secondary hyperparathyroidism. Journal of the Korean Surgical Society 83, 1\u20136, 10.4174\/jkss.2012.83.1.1 (2012).","journal-title":"Journal of the Korean Surgical Society"},{"key":"BFsrep26841_CR13","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1002\/lary.21023","volume":"120","author":"M Kara","year":"2010","unstructured":"Kara, M. et al. Evaluation of intraoperative parathormone measurement for predicting successful surgery in patients undergoing subtotal\/total parathyroidectomy due to secondary hyperparathyroidism. The Laryngoscope 120, 1538\u20131544, 10.1002\/lary.21023 (2010).","journal-title":"The Laryngoscope"},{"key":"BFsrep26841_CR14","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/ki.2015.72","volume":"88","author":"H Komaba","year":"2015","unstructured":"Komaba, H. et al. Parathyroidectomy and survival among Japanese hemodialysis patients with secondary hyperparathyroidism. 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Medicine (Baltimore) 94, e1213, 10.1097\/md.0000000000001213 (2015).","journal-title":"Medicine (Baltimore)"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep26841.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep26841","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep26841.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T05:42:59Z","timestamp":1672897379000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep26841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,27]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,6,27]]}},"alternative-id":["BFsrep26841"],"URL":"https:\/\/doi.org\/10.1038\/srep26841","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,27]]},"assertion":[{"value":"10 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"26841"}}