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However, the mechanisms of <jats:italic>S. suis<\/jats:italic> 2 survival in human blood are not well understood. In our previous study, we identified muramidase-released protein (MRP), a novel human fibrinogen (hFg)-binding protein (FBP) in <jats:italic>S. suis<\/jats:italic> 2 that is an important epidemic infection marker with an unknown mechanism in pathogenesis. The present study demonstrates that the N-terminus of MRP (a.a. 283\u2013721) binds to both the A\u03b1 and B\u03b2 chains of the D fragment of hFg. Strikingly, the hFg-MRP interaction improved the survival of <jats:italic>S. suis<\/jats:italic> 2 in human blood and led to the aggregation and exhaustion of polymorphonuclear neutrophils (PMNs) via an \u03b1<jats:sub>X<\/jats:sub>\u03b2<jats:sub>2<\/jats:sub> integrin-dependent mechanism. Other Fg-binding proteins, such as M1 (GAS) and FOG (GGS), also induced PMNs aggregation; however, the mechanisms of these FBP-hFg complexes in the evasion of PMN-mediated innate immunity remain unclear. MRP is conserved across highly virulent strains in Europe and Asia and these data shed new light on the function of MRP in <jats:italic>S. suis<\/jats:italic> pathogenesis.<\/jats:p>","DOI":"10.1038\/srep26966","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T09:12:43Z","timestamp":1464340363000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Binding of Human Fibrinogen to MRP Enhances Streptococcus suis Survival in Host Blood in a \u03b1X\u03b22 Integrin-dependent Manner"],"prefix":"10.1038","volume":"6","author":[{"given":"Yaya","family":"Pian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,5,27]]},"reference":[{"key":"BFsrep26966_CR1","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1371\/journal.pmed.0030151","volume":"3","author":"J Tang","year":"2006","unstructured":"Tang, J. et al. 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