{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:43:50Z","timestamp":1774226630438,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T00:00:00Z","timestamp":1464912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the present study was to comprehensively evaluate the clinical features and long-term outcomes of congenital aural stenosis (CAS). This study presents a retrospective review of patients who underwent meatoplasty for CAS at a tertiary referral hospital from 2008 to 2015. A total of 246 meatoplasty procedures were performed on 232 patients in the present study. We performed multivariate regression analysis. Except in the age\u2009&lt;\u20096 years group, no significant difference was observed among different age groups for cholesteatoma formation, p\u2009&gt;\u20090.05. Except for the stenosis of the external auditory canal (EAC) (&gt;4\u2009mm) group, the other stenosis of EAC groups were not associated with cholesteatoma formation, p\u2009&gt;\u20090.05. Postoperative air-bone gaps (ABG) less than 30 dB occurred in 77.3% (99\/128) of the patients, and the Jahrsdoerfer score was associated with postoperative ABG, p\u2009&lt;\u20090.001. The complication rate of CAS was 13.8% (20\/144), and males showed a higher risk for postoperative complications (OR, 6.563; 95% CI, 1.268\u201333.966, p\u2009=\u20090.025). These results indicate that meatoplasty was an effective surgical intervention for CAS, showing a stable hearing outcome with prolonged follow-up. There was no significant difference between the cholesteatoma and no cholesteatoma groups for hearing outcomes, p\u2009&gt;\u20090.05.<\/jats:p>","DOI":"10.1038\/srep27063","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T09:40:50Z","timestamp":1464946850000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Congenital Aural Stenosis: Clinical Features and Long-term Outcomes"],"prefix":"10.1038","volume":"6","author":[{"given":"Chen-long","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-zheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao-yao","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,3]]},"reference":[{"key":"BFsrep27063_CR1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1288\/00005537-199006000-00004","volume":"100","author":"RR Cole","year":"1990","unstructured":"Cole, R. R. & Jahrsdoerfer, R. A. The risk of cholesteatoma in congenital aural stenosis. Laryngoscope 100, 576\u2013578 (1990).","journal-title":"Laryngoscope"},{"key":"BFsrep27063_CR2","first-page":"53","volume":"18","author":"TE Mayer","year":"1997","unstructured":"Mayer, T. E., Brueckmann, H., Siegert, R., Witt, A. & Weerda, H. High-resolution CT of the temporal bone in dysplasia of the auricle and external auditory canal. AJNR Am J Neuroradiol 18, 53\u201365 (1997).","journal-title":"AJNR Am J Neuroradiol"},{"key":"BFsrep27063_CR3","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.ejrad.2007.10.019","volume":"69","author":"S Kosling","year":"2009","unstructured":"Kosling, S., Omenzetter, M. & Bartel-Friedrich, S. Congenital malformations of the external and middle ear. Eur J Radiol 69, 269\u2013279 (2009).","journal-title":"Eur J Radiol"},{"key":"BFsrep27063_CR4","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/MOO.0b013e32833da84e","volume":"18","author":"P Dubach","year":"2010","unstructured":"Dubach, P., Mantokoudis, G. & Caversaccio, M. Ear canal cholesteatoma: meta-analysis of clinical characteristics with update on classification, staging and treatment. Curr Opin Otolaryngol Head Neck Surg 18, 369\u2013376 (2010).","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"BFsrep27063_CR5","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1097\/MAO.0000000000000495","volume":"35","author":"G Casale","year":"2014","unstructured":"Casale, G., Nicholas, B. D. & Kesser, B. W. Acquired ear canal cholesteatoma in congenital aural atresia\/stenosis. Otol Neurotol 35, 1474\u20131479 (2014).","journal-title":"Otol Neurotol"},{"key":"BFsrep27063_CR6","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1097\/MAO.0000000000000335","volume":"35","author":"T Sakamoto","year":"2014","unstructured":"Sakamoto, T. et al. Favorable prognostic factors for long-term postoperative hearing results after canal tympanoplasty for congenital aural stenosis. Otol Neurotol 35, 966\u2013971 (2014).","journal-title":"Otol Neurotol"},{"key":"BFsrep27063_CR7","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1016\/j.ijporl.2009.07.021","volume":"73","author":"RF Yellon","year":"2009","unstructured":"Yellon, R. F. Congenital external auditory canal stenosis and partial atretic plate. Int J Pediatr Otorhinolaryngol 73, 1545\u20131549 (2009).","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"BFsrep27063_CR8","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/00016480600794511","volume":"127","author":"H Yamane","year":"2007","unstructured":"Yamane, H., Takayama, M., Sunami, K., Tochino, R. & Morinaka, M. Disregard of cholesteatoma in congenital aural stenosis. Acta Otolaryngol 127, 221\u2013224 (2007).","journal-title":"Acta Otolaryngol"},{"key":"BFsrep27063_CR9","doi-asserted-by":"publisher","first-page":"476","DOI":"10.3109\/14992027.2014.890295","volume":"53","author":"C Li","year":"2014","unstructured":"Li, C., Zhang, T., Fu, Y., Qing, F. & Chi, F. Congenital aural atresia and stenosis: surgery strategies and long-term results. Int J Audiol 53, 476\u2013481 (2014).","journal-title":"Int J Audiol"},{"key":"BFsrep27063_CR10","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1017\/S0022215111002052","volume":"125","author":"A Mazita","year":"2011","unstructured":"Mazita, A., Zabri, M., Aneeza, W. H., Asma, A. & Saim, L. Cholesteatoma in patients with congenital external auditory canal anomalies: retrospective review. J Laryngol Otol 125, 1116\u20131120 (2011).","journal-title":"J Laryngol Otol"},{"key":"BFsrep27063_CR11","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1017\/S0022215113001850","volume":"127","author":"M Sayles","year":"2013","unstructured":"Sayles, M., Kamel, H. A. & Fahmy, F. F. Operative management of external auditory canal cholesteatoma: case series and literature review. J Laryngol Otol 127, 859\u2013866 (2013).","journal-title":"J Laryngol Otol"},{"key":"BFsrep27063_CR12","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1016\/j.ijporl.2014.09.001","volume":"78","author":"CL Li","year":"2014","unstructured":"Li, C. L. et al. Phenotypic characterization and risk factors for microtia in East China, a case-control study. Int J Pediatr Otorhinolaryngol 78, 2060\u20132063 (2014).","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"BFsrep27063_CR13","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1002\/ajmg.a.35888","volume":"161A","author":"DV Luquetti","year":"2013","unstructured":"Luquetti, D. V. et al. Preferential associated anomalies in 818 cases of microtia in South America. Am J Med Genet A 161A, 1051\u20131057 (2013).","journal-title":"Am J Med Genet A"},{"key":"BFsrep27063_CR14","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1038\/ejhg.2013.287","volume":"22","author":"I Barisic","year":"2014","unstructured":"Barisic, I. et al. Prevalence, prenatal diagnosis and clinical features of oculo-auriculo-vertebral spectrum: a registry-based study in Europe. Eur J Hum Genet 22, 1026\u20131033 (2014).","journal-title":"Eur J Hum Genet"},{"key":"BFsrep27063_CR15","doi-asserted-by":"publisher","first-page":"3179","DOI":"10.1007\/s00405-013-2820-6","volume":"271","author":"CW Kim","year":"2014","unstructured":"Kim, C. W., Baek, S. H., Lee, S. H., Kim, G. W. & Cho, B. K. Clinical characteristics of spontaneous cholesteatoma of the external auditory canal in children comparing with cholesteatoma in adults. Eur Arch Otorhinolaryngol 271, 3179\u20133185 (2014).","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"BFsrep27063_CR16","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1001\/archotol.131.4.326","volume":"131","author":"S Ishimoto","year":"2005","unstructured":"Ishimoto, S. et al. Correlation between microtia and temporal bone malformation evaluated using grading systems. Arch Otolaryngol Head Neck Surg 131, 326\u2013329 (2005).","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"BFsrep27063_CR17","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1002\/lary.24769","volume":"124","author":"BP Perry","year":"2014","unstructured":"Perry, B. P. & Cody, J. D. Otologic characteristics of individuals with deletions of distal 18q. Laryngoscope 124, 2606\u20132609 (2014).","journal-title":"Laryngoscope"},{"key":"BFsrep27063_CR18","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1067\/j.cpradiol.2015.05.001","volume":"44","author":"A Chawla","year":"2015","unstructured":"Chawla, A., Ezhil, B. J., Lim, T. C., Shenoy, J. N. & Krishnan, V. Computed Tomography Features of External Auditory Canal Cholesteatoma: A Pictorial Review. Curr Probl Diagn Radiol 44, 511\u2013516 (2015).","journal-title":"Curr Probl Diagn Radiol"},{"key":"BFsrep27063_CR19","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1097\/RCT.0000000000000237","volume":"39","author":"K Chen","year":"2015","unstructured":"Chen, K. et al. Morphological Characteristics of Round Window Niche in Congenital Aural Atresia and Stenosis Patients. J Comput Assist Tomogr 39, 547\u2013551 (2015).","journal-title":"J Comput Assist Tomogr"},{"key":"BFsrep27063_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/MAO.0000000000000769","volume":"36","author":"Y Chen","year":"2015","unstructured":"Chen, Y. & Zhang, T. Modified meatoplasty for external auditory canal stenosis with endoaural-conchal incision. Otol Neurotol 36, 1\u20133 (2015).","journal-title":"Otol Neurotol"},{"key":"BFsrep27063_CR21","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.ijporl.2015.03.032","volume":"79","author":"CL Li","year":"2015","unstructured":"Li, C. L., Dai, P. D., Yang, L. & Zhang, T. Y. A meta-analysis of the long-term hearing outcomes and complications associated with atresiaplasty. Int J Pediatr Otorhinolaryngol 79, 793\u2013797 (2015).","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"BFsrep27063_CR22","doi-asserted-by":"crossref","unstructured":"Zhang, L. et al. Bone conduction hearing in congenital aural atresia. Eur Arch Otorhinolaryngol, 10.1007\/s00405-015-3727-1 (2015).","DOI":"10.1007\/s00405-015-3727-1"},{"key":"BFsrep27063_CR23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1288\/00005537-198201000-00016","volume":"92","author":"PF Anthony","year":"1982","unstructured":"Anthony, P. F. & Anthony, W. P. Surgical treatment of external auditory canal cholesteatoma. Laryngoscope 92, 70\u201375 (1982).","journal-title":"Laryngoscope"},{"key":"BFsrep27063_CR24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/BF00457906","volume":"243","author":"K Makino","year":"1986","unstructured":"Makino, K. & Amatsu, M. Epithelial migration on the tympanic membrane and external canal. Arch Otorhinolaryngol 243, 39\u201342 (1986).","journal-title":"Arch Otorhinolaryngol"},{"key":"BFsrep27063_CR25","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1017\/S0022215109992763","volume":"124","author":"L Louw","year":"2010","unstructured":"Louw, L. Acquired cholesteatoma pathogenesis: stepwise explanations. J Laryngol Otol 124, 587\u2013593 (2010).","journal-title":"J Laryngol Otol"},{"key":"BFsrep27063_CR26","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1097\/01.mlg.0000157847.70907.42","volume":"115","author":"R Naim","year":"2005","unstructured":"Naim, R., Linthicum, F. J., Shen, T., Bran, G. & Hormann, K. Classification of the external auditory canal cholesteatoma. Laryngoscope 115, 455\u2013460 (2005).","journal-title":"Laryngoscope"},{"key":"BFsrep27063_CR27","unstructured":"Marx, H. Die Missbildungen des Ohres. In: Henke F., Lubarsh O., eds., In Handbuch der Spez Path anatomie Histologie 620\u2013625 (Springer, Berlin, Germany; 1926)."},{"key":"BFsrep27063_CR28","first-page":"6","volume":"13","author":"RA Jahrsdoerfer","year":"1992","unstructured":"Jahrsdoerfer, R. A., Yeakley, J. W., Aguilar, E. A., Cole, R. R. & Gray, L. C. Grading system for the selection of patients with congenital aural atresia. Am J Otol 13, 6\u201312 (1992).","journal-title":"Am J Otol"},{"key":"BFsrep27063_CR29","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/01.mao.0000227897.73032.95","volume":"28","author":"GP Digoy","year":"2007","unstructured":"Digoy, G. P. & Cueva, R. A. Congenital aural atresia: review of short- and long-term surgical results. Otol Neurotol 28, 54\u201360 (2007).","journal-title":"Otol Neurotol"},{"key":"BFsrep27063_CR30","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1007\/s00405-013-2710-y","volume":"271","author":"Q Du","year":"2014","unstructured":"Du Q. & Zhang, T. Comparison of scalp and abdomen as split-thickness skin graft donor sites for aural stenosis repair. Eur Arch Otorhinolaryngol 271, 2159\u20132164 (2014).","journal-title":"Eur Arch Otorhinolaryngol"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep27063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep27063","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep27063.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T09:48:35Z","timestamp":1718617715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep27063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,3]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,6,29]]}},"alternative-id":["BFsrep27063"],"URL":"https:\/\/doi.org\/10.1038\/srep27063","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,3]]},"assertion":[{"value":"3 November 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27063"}}