{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:26:51Z","timestamp":1791235611688,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T00:00:00Z","timestamp":1465171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Recent neuroscience research suggests that tinnitus may reflect synaptic loss in the cochlea that does not express in the audiogram but leads to neural changes in auditory pathways that reduce sound level tolerance (SLT). Adolescents (N\u2009=\u2009170) completed a questionnaire addressing their prior experience with tinnitus, potentially risky listening habits, and sensitivity to ordinary sounds, followed by psychoacoustic measurements in a sound booth. Among all adolescents 54.7% reported by questionnaire that they had previously experienced tinnitus, while 28.8% heard tinnitus in the booth. Psychoacoustic properties of tinnitus measured in the sound booth corresponded with those of chronic adult tinnitus sufferers. Neither hearing thresholds (\u226415\u2009dB HL to 16\u2009kHz) nor otoacoustic emissions discriminated between adolescents reporting or not reporting tinnitus in the sound booth, but loudness discomfort levels (a psychoacoustic measure of SLT) did so, averaging 11.3\u2009dB lower in adolescents experiencing tinnitus in the acoustic chamber. Although risky listening habits were near universal, the teenagers experiencing tinnitus and reduced SLT tended to be more protective of their hearing. Tinnitus and reduced SLT could be early indications of a vulnerability to hidden synaptic injury that is prevalent among adolescents and expressed following exposure to high level environmental sounds.<\/jats:p>","DOI":"10.1038\/srep27109","type":"journal-article","created":{"date-parts":[[2016,6,6]],"date-time":"2016-06-06T09:12:01Z","timestamp":1465204321000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Tinnitus is associated with reduced sound level tolerance in adolescents with normal audiograms and otoacoustic emissions"],"prefix":"10.1038","volume":"6","author":[{"given":"Tanit Ganz","family":"Sanchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Casseb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaci","family":"Cota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry E.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,6]]},"reference":[{"key":"BFsrep27109_CR1","doi-asserted-by":"publisher","first-page":"e70297","DOI":"10.1371\/journal.pone.0070297","volume":"8","author":"A Gilles","year":"2013","unstructured":"Gilles, A., Van Hal, G., De Ridder, D., Wouters, K. & Van de Heyning, P. Epidemiology of noise-induced tinnitus and the attitudes and beliefs towards noise and hearing protection in adolescents. PLoS One 8, e70297. doi: 10.1371\/journal.pone.0070297 (2013).","journal-title":"PLoS One"},{"key":"BFsrep27109_CR2","doi-asserted-by":"publisher","first-page":"14980","DOI":"10.1523\/JNEUROSCI.4283-10.2010","volume":"30","author":"LE Roberts","year":"2010","unstructured":"Roberts, L. E. et al. Ringing ears: The neuroscience of tinnitus. J. Neurosci. 30, 14980\u201314986 (2010).","journal-title":"J. Neurosci."},{"key":"BFsrep27109_CR3","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.heares.2010.12.003","volume":"276","author":"JATinnitus Kaltenbach","year":"2011","unstructured":"Kaltenbach, J.A. Tinnitus : Models and mechanisms. Hear. Res. 276, 52\u201360 (2011).","journal-title":"Hear. Res."},{"key":"BFsrep27109_CR4","doi-asserted-by":"crossref","unstructured":"Eggermont, J. J. The Neuroscience of Tinnitus Oxford University Press, Oxford, UK (2012).","DOI":"10.1093\/acprof:oso\/9780199605606.001.0001"},{"key":"BFsrep27109_CR5","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.heares.2012.09.010","volume":"295","author":"AJ Nore\u00f1a","year":"2013","unstructured":"Nore\u00f1a, A. J. & Farley, B. J. Tinnitus-related neural activity: Theories of generation, propagation, and centralization. Hear. Res. 295, 161\u2013171 (2013).","journal-title":"Hear. Res."},{"key":"BFsrep27109_CR6","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1007\/s10162-008-0136-9","volume":"9","author":"LE Roberts","year":"2008","unstructured":"Roberts, L. E., Moffat, G., Baumann, M., Ward, L. M. & Bosnyak, D. J. Residual inhibition functions overlap tinnitus spectra and the region of auditory threshold shift. J. Assoc. Res. Otolaryngol. 9, 417\u2013435 (2008).","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"BFsrep27109_CR7","doi-asserted-by":"publisher","first-page":"14077","DOI":"10.1523\/JNEUROSCI.2845-09.2009","volume":"29","author":"SG Kujawa","year":"2009","unstructured":"Kujawa, S. G. & Liberman, M. C. Adding insult to injury: cochlear nerve degeneration after \u201ctemporary\u201d noise-induced hearing loss. J. Neurosci. 29, 14077\u201314085 (2009).","journal-title":"J. Neurosci."},{"key":"BFsrep27109_CR8","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1152\/jn.00164.2013","volume":"110","author":"AC Furman","year":"2013","unstructured":"Furman, A. C., Kujawa, S. G. & Liberman, M. C. Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates. J. Neurophysiol. 110, 577\u2013586 (2013).","journal-title":"J. Neurophysiol."},{"key":"BFsrep27109_CR9","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1152\/jn.00184.2013","volume":"111","author":"AE Hickox","year":"2014","unstructured":"Hickox, A. E. & Liberman, M. C. Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus? J. Neurophysiol. 111, 552\u2013564 (2014).","journal-title":"J. Neurophysiol."},{"key":"BFsrep27109_CR10","first-page":"13","volume":"8","author":"E Emmerich","year":"2002","unstructured":"Emmerich, E. et al. Effects of discotheque music on audiometric results and central acoustic evoked neuromagnetic responses. Int. Tinnitus J. 8, 13\u20139 (2002).","journal-title":"Int. Tinnitus J."},{"key":"BFsrep27109_CR11","doi-asserted-by":"publisher","first-page":"13452","DOI":"10.1523\/JNEUROSCI.2156-11.2011","volume":"31","author":"R Schaette","year":"2011","unstructured":"Schaette, R. & McAlpine, D. Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model. J. Neurosci. 31, 13452\u201313457 (2011).","journal-title":"J. Neurosci."},{"key":"BFsrep27109_CR12","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s10162-012-0344-1","volume":"13","author":"JW Gu","year":"2012","unstructured":"Gu, J. W., Herrmann, B. S., Levine, R. A. & Melcher, J. R. Brainstem auditory evoked potentials suggest a role for the ventral cochlear nucleus in tinnitus. J. Assoc. Res. Otolaryngol. 13, 819\u2013833 (2012).","journal-title":"J. Assoc. Res. Otolaryngol."},{"key":"BFsrep27109_CR13","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1523\/JNEUROSCI.3461-12.2013","volume":"33","author":"S H\u00e9bert","year":"2013","unstructured":"H\u00e9bert, S., Fournier, P. & Nore\u00f1a, A. J. The auditory sensitivity is increased in tinnitus ears. J. Neurosci. 33, 2356\u20132364 (2013).","journal-title":"J. Neurosci."},{"key":"BFsrep27109_CR14","doi-asserted-by":"publisher","first-page":"7509","DOI":"10.1523\/JNEUROSCI.5138-14.2015","volume":"35","author":"KA Fernandez","year":"2015","unstructured":"Fernandez, K. A., Jeffers, P. W. C., Lall, K., Liberman, M. C. & Kujawa, S. G. Aging after Noise Exposure: Acceleration of Cochlear Synaptopathy in \u201cRecovered\u201d Ears. J. Neurosci. 35, 7509\u20137520 (2015).","journal-title":"J. Neurosci."},{"key":"BFsrep27109_CR15","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.ijporl.2012.11.009","volume":"77","author":"DM Baguley","year":"2013","unstructured":"Baguley, D. M., Bartnik, G., Kleinjung, T., Savastano, M. & Hough, E. Troublesome tinnitus in childhood and adolescence: Data from expert centres. Intern. J. Ped. Otorhinolaryngol. 77, 248\u2013251 (2013).","journal-title":"Intern. J. Ped. Otorhinolaryngol."},{"key":"BFsrep27109_CR16","first-page":"133","volume":"12","author":"RH Nodar","year":"1972","unstructured":"Nodar, R. H. Tinnitus aurium in school age children: a survey. J. Auditory Research 12, 133\u2013135 (1972).","journal-title":"J. Auditory Research"},{"key":"BFsrep27109_CR17","first-page":"172","volume":"85","author":"JM Graham","year":"1981","unstructured":"Graham, J. M. Tinnitus in children with hearing loss. Ciba Found. Symp. 85, 172\u2013192 (1981).","journal-title":"Ciba Found. Symp."},{"key":"BFsrep27109_CR18","unstructured":"Leonard, G., Black, F. & Schramm, J. Tinnitus in children. In, Bluestone C. D., Stool S., Arjona S., Eds. Pediatric Otolaryngology, Philadelphia: W. Saunders, 271\u2013277 (1983)."},{"key":"BFsrep27109_CR19","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0165-5876(84)80050-6","volume":"7","author":"RP Mills","year":"1984","unstructured":"Mills, R. P. & Cherry, J. R. Subjective tinnitus in children with otological disorders. Int. J. Pediatr. Otorhinolaryngol. 7, 21\u201327 (1984).","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"BFsrep27109_CR20","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1017\/S1755146300090521","volume":"9","author":"R Nodar","year":"1984","unstructured":"Nodar, R. & Lezak, M. Paediatric tinnitus: a thesis revisited. J. Laryng. Otol. 9, 234\u2013235 (1984).","journal-title":"J. Laryng. Otol."},{"key":"BFsrep27109_CR21","unstructured":"Stouffer, J., Tyler, R. & Booth, J. In Tinnitus 91 \u2013 Proceedings of IV International Tinnitus Seminar, Vol.1 (ed Aran, J. M. ) 255\u2013258 (Kugler, 1991)."},{"key":"BFsrep27109_CR22","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s00431-003-1183-1","volume":"162","author":"KM Holgers","year":"2003","unstructured":"Holgers, K. M. Tinnitus in 7-year-old children. Eur. J. Pediatr. 162, 276\u2013278 (2003).","journal-title":"Eur. J. Pediatr."},{"key":"BFsrep27109_CR23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0079-6123(07)66016-6","volume":"166","author":"CCB Coelho","year":"2007","unstructured":"Coelho, C. C. B., Sanchez, T. G. & Tyler, R. S. Tinnitus in children and associated risk factors. Prog. Brain. Res. 166, 179\u2013191 (2007).","journal-title":"Prog. Brain. Res."},{"key":"BFsrep27109_CR24","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1016\/j.ijporl.2009.04.018","volume":"73","author":"SF Bulbul","year":"2009","unstructured":"Bulbul, S. F., Muluk, N. B., Cakir, E. P. & Tufan, E. Subjective tinnitus and hearing problems in adolescents. Int. J. Pediatr. Otorhinolaryngol. 73, 1124\u20131131 (2009).","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"BFsrep27109_CR25","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1080\/14992020902971331","volume":"48","author":"AM Zocoli","year":"2009","unstructured":"Zocoli, A. M., Morata, T. C., Marques, J. M. & Corteletti, L. J. Brazilian young adults and noise: attitudes, habits, and audiological characteristics. Int. J. Audiol 48, 692\u2013699 (2009).","journal-title":"Int. J. Audiol"},{"key":"BFsrep27109_CR26","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jadohealth.2010.06.014","volume":"48","author":"AL Berg","year":"2011","unstructured":"Berg, A. L. & Serpanos, Y. C. High frequency hearing sensitivity in adolescent females of a lower socioeconomic status over a period of 24 years (1985-2008). J. Adolesc. Health 48, 203\u2013208 (2011).","journal-title":"J. Adolesc. Health"},{"key":"BFsrep27109_CR27","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1590\/S1516-18462010005000129","volume":"13","author":"ABM Lacerda","year":"2011","unstructured":"Lacerda, A. B. M., Gon\u00e7alves, C. G. O., Zocoli, A. M. F., Diaz, C. & Paula, K. H\u00e1bitos auditivos e comportamento de adolescentes diante das atividades de lazer ruidosas. Rev. CEFAC 13, 322\u2013329 (2011).","journal-title":"Rev. CEFAC"},{"key":"BFsrep27109_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1136\/archdischild-2011-300270","volume":"97","author":"J Juul","year":"2012","unstructured":"Juul, J., Barren\u00e4s, M. L. & Holgers, K. M. Tinnitus and hearing in 7-year-old children. Arch. Dis. Child. 97, 28\u201330 (2012).","journal-title":"Arch. Dis. Child."},{"key":"BFsrep27109_CR29","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1002\/lary.23482","volume":"122","author":"YH Kim","year":"2012","unstructured":"Kim, Y. H. et al. Tinnitus in children: association with stress and trait anxiety. Laryngoscope 122, 2279\u20132284 (2012).","journal-title":"Laryngoscope"},{"key":"BFsrep27109_CR30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.5935\/1808-8694.20120005","volume":"78","author":"KAB Knobel","year":"2012","unstructured":"Knobel, K. A. B. & Lima, M. C. M. P. Os pais conhecem as queixas auditivas de seus filhos? Braz J. Otorhinolaryngol. 78, 27\u201337 (2012).","journal-title":"Braz J. Otorhinolaryngol."},{"key":"BFsrep27109_CR31","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1159\/000066156","volume":"7","author":"A Nore\u00f1a","year":"2002","unstructured":"Nore\u00f1a, A., Micheyl, C., Ch\u00e9ry-Croze, S. & Collet, L. Psychoacoustic characterization of the tinnitus spectrum: Implications for the underlying mechanisms of tinnitus. Audiol. Neurootol. 7, 358\u2013369 (2002).","journal-title":"Audiol. Neurootol."},{"key":"BFsrep27109_CR32","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1159\/000080267","volume":"9","author":"C Cuny","year":"2004","unstructured":"Cuny, C., Nore\u00f1a, A., El Massioui, F. & Ch\u00e9ry-Croze, S. Reduced attention shift in response to auditory changes in subjects with tinnitus. Audiol. Neurootol, 9, 294\u2013302 (2004).","journal-title":"Audiol. Neurootol"},{"key":"BFsrep27109_CR33","doi-asserted-by":"crossref","unstructured":"Paul, B. T., Bruce, I. C., Bosnyak, D. J., Thompson, D. C. & Roberts, L. E. Modulation of electrocortical brain activity by attention in individuals with and without tinnitus. Neural Plasticity, Article ID 127824 doi: 10.1155\/2014\/127824 (2014).","DOI":"10.1155\/2014\/127824"},{"key":"BFsrep27109_CR34","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1016\/j.neubiorev.2013.07.007","volume":"37","author":"LE Roberts","year":"2013","unstructured":"Roberts, L. E., Husain, F. T. & Eggermont, J. J. Role of attention in the generation and modulation of tinnitus. Neuroscience and Biobehavioral Reviews, 37, 1754\u20131773 (2013).","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"BFsrep27109_CR35","doi-asserted-by":"crossref","unstructured":"H\u00e9bert, S., Canlon, B. & Hasson, D. Emotional exhaustion as a predictor of tinnitus. Psychother Psychosom 81, 324\u2013326. doi: 10.1159\/00033504.","DOI":"10.1159\/000335043"},{"key":"BFsrep27109_CR36","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1472-6815-12-4","volume":"12","author":"VL Simoens","year":"2012","unstructured":"Simoens, V. L. & H\u00e9bert, S. Cortisol suppression and hearing thresholds in tinnitus after low-dose dexamethasone challenge. BMC Ear, Nose and Throat Disorders 12, 4 (2012).","journal-title":"BMC Ear, Nose and Throat Disorders"},{"key":"BFsrep27109_CR37","doi-asserted-by":"publisher","first-page":"14974","DOI":"10.1073\/pnas.1107998108","volume":"108","author":"S Yang","year":"2011","unstructured":"Yang, S., Weiner, B. D., Zhang, L. S., Cho, S. J. & Bao, S. Homeostatic plasticity drives tinnitus perception in an animal model. Proc. Nat. Acad. Sci. USA 108, 14974\u201314979 (2011).","journal-title":"Proc. Nat. Acad. Sci. USA"},{"key":"BFsrep27109_CR38","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nrn1327","volume":"5","author":"GG Turrigiano","year":"2004","unstructured":"Turrigiano, G. G. & Nelson, S. B. Homeostatic plasticity in the developing nervous system. Nat Rev Neurosci 5, 97\u2013107 (2004)","journal-title":"Nat Rev Neurosci"},{"key":"BFsrep27109_CR39","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neuron.2010.04.028","volume":"66","author":"K Pozo","year":"2010","unstructured":"Pozo, K. & Goda, Y. Unraveling mechanisms of homeostatic synaptic plasticity. Neuron 66, 337\u2013351 (2010).","journal-title":"Neuron"},{"key":"BFsrep27109_CR40","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1523\/JNEUROSCI.0208-09.2009","volume":"29","author":"C Zeng","year":"2009","unstructured":"Zeng, C., Nannapaneni, N., Zhou, J., Hughes, L. F. & Shore, S. Cochlear damage changes the distribution of vesicular glutamate transporters associated with auditory and nonauditory inputs to the cochlear nucleus. J Neurosci 29, 4210\u20134217 (2009).","journal-title":"J Neurosci"},{"key":"BFsrep27109_CR41","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1523\/JNEUROSCI.3915-14.2015","volume":"35","author":"HM Bharadwaj","year":"2015","unstructured":"Bharadwaj, H. M., Masud, S., Mehraei, G., Verhulst, S. & Shinn-Cunningham, B. G. Individual differences reveal correlates of hidden hearing deficits. J Neurosci 35, 2161\u20132172 (2015).","journal-title":"J Neurosci"},{"key":"BFsrep27109_CR42","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/S0378-5955(99)00223-3","volume":"141","author":"GA Gates","year":"2000","unstructured":"Gates, G. A., Schmid, P., Kujawa, S. G., Nam, B. & D\u2019Agostino, R. Longitudinal threshold changes in older men with audiometric notches. Hear. Res. 141, 220\u2013228 (2000).","journal-title":"Hear. Res."},{"key":"BFsrep27109_CR43","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1002\/lary.24015","volume":"123","author":"H Mahboubi","year":"2013","unstructured":"Mahboubi, H., Oliaei, S., Kiumehr, S., Dwabe, S. & Djalilian, H. R. The prevalence and characteristics of tinnitus in the youth population of the United States. Laryngoscope 123, 2001\u20132008 (2013).","journal-title":"Laryngoscope"},{"key":"BFsrep27109_CR44","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1044\/0161-1461.1401.22","volume":"14","author":"C Woodford","year":"1983","unstructured":"Woodford, C. & O\u2019Farrel, M. High-frequency loss of hearing in secondary school students: an investigation of possible etiologic factors. Language, Speech, and Hearing Services in Schools 14, 22\u201328 (1983).","journal-title":"Language, Speech, and Hearing Services in Schools"},{"key":"BFsrep27109_CR45","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1044\/0161-1461.2201.308","volume":"22","author":"GD Chemark","year":"1991","unstructured":"Chemark, G. D. & Peters-McCarthy, E. The effectiveness of an educational hearing conservation program for elementary school children. Language, Speech, and Hearing Services in Schools 22, 308\u2013312 (1991).","journal-title":"Language, Speech, and Hearing Services in Schools"},{"key":"BFsrep27109_CR46","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1044\/0161-1461.2301.61","volume":"23","author":"JK Montgomery","year":"1992","unstructured":"Montgomery, J. K. & Fujikawa, S. Hearing thresholds of students in the second, eighth, and twelfth grades. Language, Speech and Hearing Services in Schools 23, 61\u201363 (1992).","journal-title":"Language, Speech and Hearing Services in Schools"},{"key":"BFsrep27109_CR47","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1093\/her\/cyq018","volume":"25","author":"I Vogel","year":"2010","unstructured":"Vogel, I., Brug, J., Van der Ploeg, C. P. & Raat, H. Discotheques and the risk of hearing loss among youth: risky listening behavior and its psychosocial correlates. Health Educ Res 25, 737\u2013747 (2010).","journal-title":"Health Educ Res"},{"key":"BFsrep27109_CR48","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1542\/peds.2010-0926","volume":"12","author":"E Henderson","year":"2011","unstructured":"Henderson, E., Testa, M. A. & Hartnick, C. Prevalence of noise-induced hearing-threshold shifts and hearing loss among US youths. Pediatrics, 12, 39\u201346. doi: 10.1542\/peds.2010-0926 (2011).","journal-title":"Pediatrics"},{"key":"BFsrep27109_CR49","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1001\/jama.2010.1124","volume":"304","author":"J Shargorodsky","year":"2010","unstructured":"Shargorodsky, J., Curhan, S. G., Curhan, G. C. & Eavey, R. Change in prevalence of hearing loss in US adolescents J Am Med Assoc 304, 772\u2013778 (2010).","journal-title":"J Am Med Assoc"},{"key":"BFsrep27109_CR50","unstructured":"Roberts, L. E. In Perspectives on Tinnitus (eds Baguley, D. & Fagelson, M. ), Ch 2 13\u201333 (Plural, 2015)."},{"key":"BFsrep27109_CR51","doi-asserted-by":"publisher","first-page":"16141","DOI":"10.1523\/JNEUROSCI.2499-12.2012","volume":"32","author":"DA Llano","year":"2012","unstructured":"Llano, D. A., Turner, J. & Caspary, D. M. Diminished cortical inhibition in an aging mouse model of chronic tinnitus. J. Neurosci. 32, 16141\u201316148 (2012).","journal-title":"J. Neurosci."},{"key":"BFsrep27109_CR52","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.heares.2015.04.014","volume":"327","author":"LM Viana","year":"2015","unstructured":"Viana, L. M. et al. Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue. Hear. Res. 327, 78\u201388, doi: 10.1016\/j.heares.2015.04.014 (2015).","journal-title":"Hear. Res."},{"key":"BFsrep27109_CR53","doi-asserted-by":"crossref","unstructured":"Shaheen, L. A., Valero, M. D. & Liberman, M. C. Towards a diagnosis of cochlear neuropathy with envelope following responses. J. Assoc Res Otolaryngol doi: 10.1007\/s10162-015-0539-3 (2015).","DOI":"10.1007\/s10162-015-0539-3"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep27109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep27109","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep27109.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T05:09:46Z","timestamp":1672895386000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep27109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,6]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,6,29]]}},"alternative-id":["BFsrep27109"],"URL":"https:\/\/doi.org\/10.1038\/srep27109","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,6]]},"assertion":[{"value":"4 January 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27109"}}