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RCTs with cardiac biomarkers, in MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials from 1975\u20132013 were reviewed considering all cause mortality, recurrent non-fatal myocardial infarction (MI) and their combination. Follow-up lasted from 6\u201324 months and the use of routine invasive strategy up to its end was associated with a significantly lower composite of all-cause mortality and recurrent non-fatal MI (Relative Risk [RR] 0.79; 95% confidence interval [CI], 0.70\u20130.90) in UA\/NSTEMI. In NSTEMI, by the invasive strategy, there was no benefit (RR 1.19; 95%\u2009CI, 1.03\u20131.38). In the shorter time period, from randomization to discharge, a routine invasive strategy was associated with significantly higher odds of the combined end-point among UA\/NSTEMI (RR 1.29; 95%\u2009CI, 1.05\u20131.58) and NSTEMI (RR 1.82; 95%\u2009CI, 1.34\u20132.48) patients. Therefore, in trials recruiting a large number of UA patients, by routine invasive strategy the largest benefit was seen, whereas in NSTEMI patients death and non-fatal MI were not lowered. Routine invasive treatment in UA patients is accordingly supported by the present study.<\/jats:p>","DOI":"10.1038\/srep27345","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T09:10:14Z","timestamp":1465290614000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Early Invasive Strategy for Unstable Angina: a New Meta-Analysis of Old Clinical Trials"],"prefix":"10.1038","volume":"6","author":[{"given":"Olivia","family":"Manfrini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada","family":"Dormi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo Emilio","family":"Puddu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edina","family":"Cenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Bugiardini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,7]]},"reference":[{"key":"BFsrep27345_CR1","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1161\/CIR.0b013e318256f1e0","volume":"126","author":"H Jneid","year":"2012","unstructured":"Writing Committee Members. 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