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Thirty three 36-week old male mice were divided into four groups: normal control (<jats:italic>db\/m<\/jats:italic>) (n\u2009=\u20097), leptin receptor-deficient T2DM (<jats:italic>db\/db<\/jats:italic>) (n\u2009=\u20098), human C-reactive protein (CRP) transgenic normal control (<jats:italic>crp\/db\/m<\/jats:italic>) (n\u2009=\u20097) and human CRP transgenic T2DM (<jats:italic>crp\/db\/db<\/jats:italic>) (n\u2009=\u200911). Lumber vertebrae (L5) and bilateral lower limbs were scanned by micro-CT to analyze trabecular and cortical bone quality. Right femora were used for three-point bending to analyze the mechanical properties. Trabecular bone quality at L5 was better in <jats:italic>db\/db<\/jats:italic> or <jats:italic>crp\/db\/db<\/jats:italic> group in terms of bone mineral density (BMD), bone volume fraction, connectivity density, trabecular number and separation (all p\u2009&lt;\u20090.05). However the indices measured at proximal tibia showed comparable trabecular BMD and microarchitecture among the four groups. Femur length in <jats:italic>crp\/db\/db<\/jats:italic> group was significantly shorter than <jats:italic>db\/m<\/jats:italic> group (p\u2009&lt;\u20090.05) and cortices were thinner in <jats:italic>db\/db<\/jats:italic> and <jats:italic>crp\/db\/db<\/jats:italic> groups (p\u2009&gt;\u20090.05). Maximum loading and energy yield in mechanical test were similar among groups while the elastic modulus in <jats:italic>db\/db<\/jats:italic> and <jats:italic>crp\/db\/db<\/jats:italic> significantly lower than <jats:italic>db\/m<\/jats:italic>. The leptin-receptor mice is not a proper model for secondary osteoporosis associated with T2DM.<\/jats:p>","DOI":"10.1038\/srep27745","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T09:20:49Z","timestamp":1465550449000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Validity of leptin receptor-deficiency (db\/db) type 2 diabetes mellitus mice as a model of secondary osteoporosis"],"prefix":"10.1038","volume":"6","author":[{"given":"Le","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-ke","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy Y","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-zhen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-ru","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-yao","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"key":"BFsrep27745_CR1","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s00467-007-0733-6","volume":"23","author":"H Ziolkowska","year":"2008","unstructured":"Ziolkowska, H., Brzewski, M. & Roszkowska-Blaim, M. 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