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The present case-control study aimed to explore the potential relationship between putative periodontopathic bacteria and herpesviruses in maternal chronic periodontitis.Saliva samples were collected from 36 pregnant women with chronic periodontitis (cases) and 36 pregnant women with healthy periodontal status (controls). Six putative periodontopathic bacteria (<jats:italic>Porphyromonas gingivalis<\/jats:italic>[Pg],<jats:italic>Aggregatibacer actinomycetemcomitans<\/jats:italic>[Aa],<jats:italic>Fusobacterium nucleatum<\/jats:italic>[Fn],<jats:italic>Prevotella intermedia<\/jats:italic>[Pi],<jats:italic>Tannerella forsythia<\/jats:italic>[Tf], and<jats:italic>Treponema denticola<\/jats:italic>[Td]) and three herpesviruses (Epstein-Barr virus [EBV], human cytomegalovirus [HCMV], and herpes simplex virus [HSV]) were detected. Socio-demographic data and oral health related behaviors, and salivary estradiol and progesterone levels were also collected. The results showed no significant differences in socio-demographic background, oral health related behaviors, and salivary estradiol and progesterone levels between the two groups (all<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). The detection rates of included periodontopathic microorganisms were not significantly different between the two groups (all<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05), but the coinfection rate of EBV and Pg was significantly higher in the case group than in the control group (<jats:italic>P<\/jats:italic>\u2009=\u20090.028). EBV and Pg coinfection may promote the development of chronic periodontitis among pregnant women.<\/jats:p>","DOI":"10.1038\/srep27796","type":"journal-article","created":{"date-parts":[[2016,6,15]],"date-time":"2016-06-15T16:34:33Z","timestamp":1466008473000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Putative periodontopathic bacteria and herpesviruses in pregnant women: a case-control study"],"prefix":"10.1038","volume":"6","author":[{"given":"Haixia","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danying","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,15]]},"reference":[{"key":"BFsrep27796_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jri.2015.05.002","volume":"112","author":"B Penova-Veselinovic","year":"2015","unstructured":"Penova-Veselinovic, B., Keelan, J. 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