{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:51:29Z","timestamp":1787061089315,"version":"build-2736575974"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Leptin is an adipokine that regulates various metabolism, but its association with secondary hyperparathyroidism (SHPT), a clinical manifestation of chronic kidney disease-mineral and bone disorder (CKD-MBD), remains obscure. Parathyroidectomy (PTX) is recommended for severe SHPT patients. Here, the associations between circulating leptin and clinical characteristics in CKD patients were investigated. Effects of PTX on leptin production were analyzed\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    . Controls and CKD patients had approximate serum leptin levels in that a larger proportion of CKD patients with body mass index (BMI) &lt;23\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    . Serum leptin was related to anemia, albumin, and bone metabolism disorders in CKD patients. Lower intact parathyroid hormone (PTH) was related with higher leptin in PTX patients group. Severe SHPT inhibited uremia-enhanced leptin production in 3T3-L1 adipocytes, which was attenuated after PTX. High levels of PTH were found to reduce Akt phosphorylation and leptin production\n                    <jats:italic>in vitro<\/jats:italic>\n                    but high levels of calcium and phosphorus were not. Successful PTX was found to improve anemia and malnutrition in severe SHPT patients, and this was correlated with increased circulating leptin levels via up-regulated Akt signaling in adipocytes. These findings indicated the therapeutic potential of leptin and related target pathway for improving survival and quality of life in CKD.\n                  <\/jats:p>","DOI":"10.1038\/srep27918","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T05:48:36Z","timestamp":1466056116000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of Increased Serum Leptin with Ameliorated Anemia and Malnutrition in Stage 5 Chronic Kidney Disease Patients after Parathyroidectomy"],"prefix":"10.1038","volume":"6","author":[{"given":"Yao","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanggang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changying","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"BFsrep27918_CR1","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1046\/j.1523-1755.1998.00929.x","volume":"53","author":"K Sharma","year":"1998","unstructured":"Sharma, K. & Considine, R. V. The Ob protein (leptin) and the kidney. Kidney Int 53, 1483\u20131487, doi: 10.1046\/j.1523-1755.1998.00929.x (1998).","journal-title":"Kidney Int"},{"key":"BFsrep27918_CR2","doi-asserted-by":"publisher","first-page":"e0122009","DOI":"10.1371\/journal.pone.0122009","volume":"10","author":"CC Lim","year":"2015","unstructured":"Lim, C. C. et al. Elevated serum leptin, adiponectin and leptin to adiponectin ratio is associated with chronic kidney disease in asian adults. PLoS One 10, e0122009, doi: 10.1371\/journal.pone.0122009 (2015).","journal-title":"PLoS One"},{"key":"BFsrep27918_CR3","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s40620-013-0015-2","volume":"27","author":"MC Maggio","year":"2014","unstructured":"Maggio, M. C. et al. Adiponectin, resistin and leptin in paediatric chronic renal failure: correlation with auxological and endocrine profiles. J Nephrol 27, 275\u2013279, doi: 10.1007\/s40620-013-0015-2 (2014).","journal-title":"J Nephrol"},{"key":"BFsrep27918_CR4","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1681\/ASN.V891423","volume":"8","author":"O Heimburger","year":"1997","unstructured":"Heimburger, O., Lonnqvist, F., Danielsson, A., Nordenstrom, J. & Stenvinkel, P. Serum immunoreactive leptin concentration and its relation to the body fat content in chronic renal failure. J Am Soc Nephrol 8, 1423\u20131430, doi: 1046-6673\/0809-1423$03.00\/0 (1997).","journal-title":"J Am Soc Nephrol"},{"key":"BFsrep27918_CR5","doi-asserted-by":"publisher","first-page":"S206","DOI":"10.1681\/asn.2006080916","volume":"17","author":"SG de Vinuesa","year":"2006","unstructured":"de Vinuesa, S. G. et al. Insulin resistance, inflammatory biomarkers, and adipokines in patients with chronic kidney disease: effects of angiotensin II blockade. J Am Soc Nephrol 17, S206\u2013212, doi: 10.1681\/asn.2006080916 (2006).","journal-title":"J Am Soc Nephrol"},{"key":"BFsrep27918_CR6","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.jpeds.2014.06.030","volume":"165","author":"E Nehus","year":"2014","unstructured":"Nehus, E., Furth, S., Warady, B. & Mitsnefes, M. Correlates of leptin in children with chronic kidney disease. J Pediatr 165, 825\u2013829, doi: 10.1016\/j.jpeds.2014.06.030 (2014).","journal-title":"J Pediatr"},{"key":"BFsrep27918_CR7","doi-asserted-by":"publisher","first-page":"e76902","DOI":"10.1371\/journal.pone.0076902","volume":"8","author":"KT Mills","year":"2013","unstructured":"Mills, K. T. et al. Circulating adipocytokines and chronic kidney disease. PLoS One 8, e76902, doi: 10.1371\/journal.pone.0076902 (2013).","journal-title":"PLoS One"},{"key":"BFsrep27918_CR8","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1097\/01.ASN.0000083903.18724.93","volume":"14","author":"D Teta","year":"2003","unstructured":"Teta, D. et al. Acidosis downregulates leptin production from cultured adipocytes through a glucose transport-dependent post-transcriptional mechanism. J Am Soc Nephrol 14, 2248\u20132254 (2003).","journal-title":"J Am Soc Nephrol"},{"key":"BFsrep27918_CR9","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1053\/j.jrn.2010.11.009","volume":"21","author":"E Kalbacher","year":"2011","unstructured":"Kalbacher, E. et al. Human uremic plasma and not urea induces exuberant secretion of leptin in 3T3-L1 adipocytes. J Ren Nutr 21, 72\u201375, doi: 10.1053\/j.jrn.2010.11.009 (2011).","journal-title":"J Ren Nutr"},{"key":"BFsrep27918_CR10","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.2337\/diab.45.12.1744","volume":"45","author":"A Kosaki","year":"1996","unstructured":"Kosaki, A., Yamada, K. & Kuzuya, H. Reduced expression of the leptin gene (ob) by catecholamine through a G(S) protein-coupled pathway in 3T3-L1 adipocytes. Diabetes 45, 1744\u20131749 (1996).","journal-title":"Diabetes"},{"key":"BFsrep27918_CR11","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1016\/j.yexcr.2008.04.003","volume":"314","author":"A Zeigerer","year":"2008","unstructured":"Zeigerer, A., Rodeheffer, M. S., McGraw, T. E. & Friedman, J. M. Insulin regulates leptin secretion from 3T3-L1 adipocytes by a PI 3 kinase independent mechanism. Exp Cell Res 314, 2249\u20132256, doi: 10.1016\/j.yexcr.2008.04.003 (2008).","journal-title":"Exp Cell Res"},{"key":"BFsrep27918_CR12","doi-asserted-by":"publisher","first-page":"272","DOI":"10.2337\/diabetes.48.2.272","volume":"48","author":"RL Bradley","year":"1999","unstructured":"Bradley, R. L. & Cheatham, B. Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes. Diabetes 48, 272\u2013278 (1999).","journal-title":"Diabetes"},{"key":"BFsrep27918_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2337\/diabetes.52.1.43","volume":"52","author":"NG Patel","year":"2003","unstructured":"Patel, N. G., Holder, J. C., Smith, S. A., Kumar, S. & Eggo, M. C. Differential regulation of lipogenesis and leptin production by independent signaling pathways and rosiglitazone during human adipocyte differentiation. Diabetes 52, 43\u201350, doi: 10.2337\/diabetes.52.1.43 (2003).","journal-title":"Diabetes"},{"key":"BFsrep27918_CR14","doi-asserted-by":"publisher","first-page":"913","DOI":"10.2215\/cjn.06040710","volume":"6","author":"J Cunningham","year":"2011","unstructured":"Cunningham, J., Locatelli, F. & Rodriguez, M. Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options. Clin J Am Soc Nephrol 6, 913\u2013921, doi: 10.2215\/cjn.06040710 (2011).","journal-title":"Clin J Am Soc Nephrol"},{"key":"BFsrep27918_CR15","doi-asserted-by":"crossref","unstructured":"Kidney Disease: Improving Global Outcomes, C. K. D. M. B. D. W. G. KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD). Kidney Int Suppl S1\u2013130, doi: 10.1038\/ki.2009.188 (2009).","DOI":"10.1038\/ki.2009.188"},{"key":"BFsrep27918_CR16","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.2215\/cjn.10381012","volume":"8","author":"J Zhang","year":"2013","unstructured":"Zhang, J. et al. Parathyroidectomy and heart rate variability in patients with stage 5 CKD. Clin J Am Soc Nephrol 8, 1378\u20131387, doi: 10.2215\/cjn.10381012 (2013).","journal-title":"Clin J Am Soc Nephrol"},{"key":"BFsrep27918_CR17","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.cmet.2013.05.010","volume":"18","author":"M Dalamaga","year":"2013","unstructured":"Dalamaga, M. et al. Leptin at the intersection of neuroendocrinology and metabolism: current evidence and therapeutic perspectives. Cell Metab 18, 29\u201342, doi: 10.1016\/j.cmet.2013.05.010 (2013).","journal-title":"Cell Metab"},{"key":"BFsrep27918_CR18","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.metabol.2014.08.004","volume":"64","author":"HK Park","year":"2015","unstructured":"Park, H. K. & Ahima, R. S. Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism 64, 24\u201334, doi: 10.1016\/j.metabol.2014.08.004 (2015).","journal-title":"Metabolism"},{"key":"BFsrep27918_CR19","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1681\/ASN.2009121285","volume":"21","author":"G Contreras","year":"2010","unstructured":"Contreras, G. et al. Malnutrition-inflammation modifies the relationship of cholesterol with cardiovascular disease. J Am Soc Nephrol 21, 2131\u20132142, doi: 10.1681\/ASN.2009121285 (2010).","journal-title":"J Am Soc Nephrol"},{"key":"BFsrep27918_CR20","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1038\/sj.ki.5002585","volume":"73","author":"D Fouque","year":"2008","unstructured":"Fouque, D. et al. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 73, 391\u2013398, doi: 10.1038\/sj.ki.5002585 (2008).","journal-title":"Kidney Int"},{"key":"BFsrep27918_CR21","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s00198-014-2862-7","volume":"26","author":"LN Zhang","year":"2015","unstructured":"Zhang, L. N. et al. Plasma FGF23 levels and heart rate variability in patients with stage 5 CKD. Osteoporos Int 26, 395\u2013405, doi: 10.1007\/s00198-014-2862-7 (2015).","journal-title":"Osteoporos Int"},{"key":"BFsrep27918_CR22","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/ki.2015.72","volume":"88","author":"H Komaba","year":"2015","unstructured":"Komaba, H. et al. Parathyroidectomy and survival among Japanese hemodialysis patients with secondary hyperparathyroidism. Kidney Int 88, 350\u2013359, doi: 10.1038\/ki.2015.72 (2015).","journal-title":"Kidney Int"},{"key":"BFsrep27918_CR23","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.mce.2009.03.024","volume":"307","author":"E Chang","year":"2009","unstructured":"Chang, E., Donkin, S. S. & Teegarden, D. Parathyroid hormone suppresses insulin signaling in adipocytes. Mol Cell Endocrinol 307, 77\u201382, doi: 10.1016\/j.mce.2009.03.024 (2009).","journal-title":"Mol Cell Endocrinol"},{"key":"BFsrep27918_CR24","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1074\/jbc.M107923200","volume":"277","author":"JE Reusch","year":"2002","unstructured":"Reusch, J. E. & Klemm, D. J. Inhibition of cAMP-response element-binding protein activity decreases protein kinase B\/Akt expression in 3T3-L1 adipocytes and induces apoptosis. J Biol Chem 277, 1426\u20131432, doi: 10.1074\/jbc.M107923200 (2002).","journal-title":"J Biol Chem"},{"key":"BFsrep27918_CR25","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1042\/bj20131176","volume":"458","author":"Y Wang","year":"2014","unstructured":"Wang, Y. et al. Insulin-stimulated leptin secretion requires calcium and PI3K\/Akt activation. Biochem J 458, 491\u2013498, doi: 10.1042\/bj20131176 (2014).","journal-title":"Biochem J"},{"key":"BFsrep27918_CR26","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s11255-013-0623-8","volume":"46","author":"J Zhang","year":"2014","unstructured":"Zhang, J. & Wang, N. Leptin in chronic kidney disease: a link between hematopoiesis, bone metabolism, and nutrition. Int Urol Nephrol 46, 1169\u20131174, doi: 10.1007\/s11255-013-0623-8 (2014).","journal-title":"Int Urol Nephrol"},{"key":"BFsrep27918_CR27","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1081\/JDI-120026030","volume":"25","author":"JY Wang","year":"2003","unstructured":"Wang, J. Y., Lu, K. C., Lin, Y. F. & Hu, W. M. Correlation of serum leptin concentrations with body composition and gender in Taiwanese hemodialysis patients without diabetes. Ren Fail 25, 953\u2013966, doi: 10.1081\/JDI-120026030 (2003).","journal-title":"Ren Fail"},{"key":"BFsrep27918_CR28","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jss.2012.08.043","volume":"179","author":"KJ Ho","year":"2013","unstructured":"Ho, K. J. et al. Impact of uremia on human adipose tissue phenotype. J Surg Res 179, 175\u2013182, doi: 10.1016\/j.jss.2012.08.043 (2013).","journal-title":"J Surg Res"},{"key":"BFsrep27918_CR29","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1046\/j.1523-1755.1998.00088.x","volume":"54","author":"L Nordfors","year":"1998","unstructured":"Nordfors, L. et al. Low leptin gene expression and hyperleptinemia in chronic renal failure. Kidney Int 54, 1267\u20131275, doi: 10.1046\/j.1523-1755.1998.00088.x (1998).","journal-title":"Kidney Int"},{"key":"BFsrep27918_CR30","doi-asserted-by":"publisher","first-page":"442","DOI":"10.5414\/CNP72442","volume":"72","author":"S Kim","year":"2009","unstructured":"Kim, S. et al. Effective removal of leptin via hemodiafiltration with on-line endogenous reinfusion therapy. Clin Nephrol 72, 442\u2013448 (2009).","journal-title":"Clin Nephrol"},{"key":"BFsrep27918_CR31","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1093\/ndt\/gfh122","volume":"19","author":"A van Tellingen","year":"2004","unstructured":"van Tellingen, A. et al. Enhanced long-term reduction of plasma leptin concentrations by super-flux polysulfone dialysers. Nephrol Dial Transplant 19, 1198\u20131203, doi: 10.1093\/ndt\/gfh122 (2004).","journal-title":"Nephrol Dial Transplant"},{"key":"BFsrep27918_CR32","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1053\/j.ajkd.2005.06.004","volume":"46","author":"J Axelsson","year":"2005","unstructured":"Axelsson, J. et al. Body fat mass and serum leptin levels influence epoetin sensitivity in patients with ESRD. Am J Kidney Dis 46, 628\u2013634, doi: 10.1053\/j.ajkd.2005.06.004 (2005).","journal-title":"Am J Kidney Dis"},{"key":"BFsrep27918_CR33","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1053\/j.ajkd.2005.02.020","volume":"45","author":"SC Hung","year":"2005","unstructured":"Hung, S. C., Tung, T. Y., Yang, C. S. & Tarng, D. C. High-calorie supplementation increases serum leptin levels and improves response to rHuEPO in long-term hemodialysis patients. Am J Kidney Dis 45, 1073\u20131083, doi: 10.1053\/j.ajkd.2005.02.020 (2005).","journal-title":"Am J Kidney Dis"},{"key":"BFsrep27918_CR34","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1681\/ASN.2011111078","volume":"23","author":"JL Babitt","year":"2012","unstructured":"Babitt, J. L. & Lin, H. Y. Mechanisms of anemia in CKD. J Am Soc Nephrol 23, 1631\u20131634, doi: 10.1681\/ASN.2011111078 (2012).","journal-title":"J Am Soc Nephrol"},{"key":"BFsrep27918_CR35","doi-asserted-by":"publisher","first-page":"576","DOI":"10.2215\/CJN.04710709","volume":"5","author":"AE Gaweda","year":"2010","unstructured":"Gaweda, A. E., Goldsmith, L. J., Brier, M. E. & Aronoff, G. R. Iron, inflammation, dialysis adequacy, nutritional status, and hyperparathyroidism modify erythropoietic response. Clin J Am Soc Nephrol 5, 576\u2013581, doi: 10.2215\/CJN.04710709 (2010).","journal-title":"Clin J Am Soc Nephrol"},{"key":"BFsrep27918_CR36","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1182\/blood.V89.5.1507","volume":"89","author":"AA Mikhail","year":"1997","unstructured":"Mikhail, A. A. et al. Leptin stimulates fetal and adult erythroid and myeloid development. Blood 89, 1507\u20131512 (1997).","journal-title":"Blood"},{"key":"BFsrep27918_CR37","first-page":"25","volume":"84","author":"G Conzo","year":"2013","unstructured":"Conzo, G. et al. Role of parathyroidectomy on anemia control and erythropoiesis-stimulating agent need in secondary hyperparathyroidism of chronic kidney disease. A retrospective study in 30 hemodialysis patients. Ann Ital Chir 84, 25\u201331 (2013).","journal-title":"Ann Ital Chir"},{"key":"BFsrep27918_CR38","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.surg.2008.07.026","volume":"144","author":"JA Trunzo","year":"2008","unstructured":"Trunzo, J. A., McHenry, C. R., Schulak, J. A. & Wilhelm, S. M. Effect of parathyroidectomy on anemia and erythropoietin dosing in end-stage renal disease patients with hyperparathyroidism. Surgery 144, 5, doi: 10.1016\/j.surg.2008.07.026 (2008).","journal-title":"Surgery"},{"key":"BFsrep27918_CR39","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/ndt\/17.2.191","volume":"17","author":"A Wiecek","year":"2002","unstructured":"Wiecek, A., Kokot, F., Chudek, J. & Adamczak, M. The adipose tissue\u2013a novel endocrine organ of interest to the nephrologist. Nephrol Dial Transplant 17, 191\u2013195 (2002).","journal-title":"Nephrol Dial Transplant"},{"key":"BFsrep27918_CR40","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1159\/000045781","volume":"86","author":"A Rodriguez-Carmona","year":"2000","unstructured":"Rodriguez-Carmona, A., Perez Fontan, M., Cordido, F., Garcia Falcon, T. & Garcia-Buela, J. Hyperleptinemia is not correlated with markers of protein malnutrition in chronic renal failure. A cross-sectional study in predialysis, peritoneal dialysis and hemodialysis patients. Nephron 86, 274\u2013280, doi: 45781 (2000).","journal-title":"Nephron"},{"key":"BFsrep27918_CR41","doi-asserted-by":"publisher","first-page":"c76","DOI":"10.1159\/000078634","volume":"97","author":"M Bossola","year":"2004","unstructured":"Bossola, M. et al. Anorexia and serum leptin levels in hemodialysis patients. Nephron Clin Pract 97, c76\u201382, doi: 10.1159\/000078634 (2004).","journal-title":"Nephron Clin Pract"},{"key":"BFsrep27918_CR42","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1038\/oby.2007.191","volume":"15","author":"A Scholze","year":"2007","unstructured":"Scholze, A., Rattensperger, D., Zidek, W. & Tepel, M. Low serum leptin predicts mortality in patients with chronic kidney disease stage 5. Obesity (Silver Spring) 15, 1617\u20131622, doi: 10.1038\/oby.2007.191 (2007).","journal-title":"Obesity (Silver Spring)"},{"key":"BFsrep27918_CR43","doi-asserted-by":"publisher","first-page":"147","DOI":"10.5414\/CN108409","volume":"83","author":"E Kara","year":"2015","unstructured":"Kara, E. et al. Elevated serum leptin levels are associated with good nutritional status in non-obese chronic hemodialysis patients. Clin Nephrol 83, 147\u2013153, doi: 10.5414\/CN108409 (2015).","journal-title":"Clin Nephrol"},{"key":"BFsrep27918_CR44","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1464-5491.2004.01341.x","volume":"22","author":"JA Gimeno-Orna","year":"2005","unstructured":"Gimeno-Orna, J. A., Faure-Nogueras, E. & Sancho-Serrano, M. A. Usefulness of total cholesterol\/HDL-cholesterol ratio in the management of diabetic dyslipidaemia. Diabet Med 22, 26\u201331, doi: 10.1111\/j.1464-5491.2004.01341.x (2005).","journal-title":"Diabet Med"},{"key":"BFsrep27918_CR45","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1056\/Nejm200003233421202","volume":"342","author":"PM Ridker","year":"2000","unstructured":"Ridker, P. M., Hennekens, C. H., Buring, J. E. & Rifai, N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. New England Journal of Medicine 342, 836\u2013843, doi: Doi 10.1056\/Nejm200003233421202 (2000).","journal-title":"New England Journal of Medicine"},{"key":"BFsrep27918_CR46","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.2337\/diabetes.54.7.1994","volume":"54","author":"ED Javor","year":"2005","unstructured":"Javor, E. D. et al. Long-term efficacy of leptin replacement in patients with generalized lipodystrophy. Diabetes 54, 1994\u20132002, doi: 10.2337\/diabetes.54.7.1994 (2005).","journal-title":"Diabetes"},{"key":"BFsrep27918_CR47","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s11255-014-0844-5","volume":"47","author":"AM Bales","year":"2015","unstructured":"Bales, A. M. et al. Correction of metabolic acidosis in hemodialysis: consequences on serum leptin and mineral metabolism. Int Urol Nephrol 47, 177\u2013182, doi: 10.1007\/s11255-014-0844-5 (2015).","journal-title":"Int Urol Nephrol"},{"key":"BFsrep27918_CR48","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1681\/ASN.V1171303","volume":"11","author":"P Stenvinkel","year":"2000","unstructured":"Stenvinkel, P., Lindholm, B., Lonnqvist, F., Katzarski, K. & Heimburger, O. Increases in serum leptin levels during peritoneal dialysis are associated with inflammation and a decrease in lean body mass. J Am Soc Nephrol 11, 1303\u20131309 (2000).","journal-title":"J Am Soc Nephrol"},{"key":"BFsrep27918_CR49","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.biochi.2014.06.024","volume":"105","author":"PM Alix","year":"2014","unstructured":"Alix, P. M., Guebre-Egziabher, F. & Soulage, C. O. Leptin as an uremic toxin: Deleterious role of leptin in chronic kidney disease. Biochimie 105, 12\u201321, doi: 10.1016\/j.biochi.2014.06.024 (2014).","journal-title":"Biochimie"},{"key":"BFsrep27918_CR50","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1093\/qjmed\/hcg069","volume":"96","author":"DC Chan","year":"2003","unstructured":"Chan, D. C., Watts, G. F., Barrett, P. H. & Burke, V. Waist circumference, waist-to-hip ratio and body mass index as predictors of adipose tissue compartments in men. QJM 96, 441\u2013447, doi: 10.1093\/qjmed\/hcg069 (2003).","journal-title":"QJM"},{"key":"BFsrep27918_CR51","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/1471-2369-15-199","volume":"15","author":"SK Chow","year":"2014","unstructured":"Chow, S. K. & Tam, B. M. Is the kidney disease quality of life-36 (KDQOL-36) a valid instrument for Chinese dialysis patients? BMC Nephrol 15, 199, doi: 10.1186\/1471-2369-15-199 (2014).","journal-title":"BMC Nephrol"},{"key":"BFsrep27918_CR52","first-page":"1094","volume":"8","author":"G Enia","year":"1993","unstructured":"Enia, G., Sicuso, C., Alati, G. & Zoccali, C. Subjective global assessment of nutrition in dialysis patients. Nephrol Dial Transplant 8, 1094\u20131098 (1993).","journal-title":"Nephrol Dial Transplant"},{"key":"BFsrep27918_CR53","doi-asserted-by":"crossref","unstructured":"KidneyDisease:ImprovingGlobalOutcomes(KDIGO) AnemiaWorkGroup. KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease. Kidney Int Suppl. 2, 279\u2013335, doi: 10.1038\/kisup.2012.33 (2012).","DOI":"10.1038\/kisup.2012.33"},{"key":"BFsrep27918_CR54","unstructured":"KidneyDisease:ImprovingGlobalOutcomes(KDIGO) LipidWorkGroup. Clinical Practice Guideline for Lipid Management in Chronic Kidney Disease. Kidney Int suppl. 3, 46 (2013)."},{"key":"BFsrep27918_CR55","doi-asserted-by":"publisher","first-page":"668","DOI":"10.2337\/diacare.28.3.668","volume":"28","author":"EB Schroeder","year":"2005","unstructured":"Schroeder, E. B. et al. Diabetes, glucose, insulin, and heart rate variability: the Atherosclerosis Risk in Communities (ARIC) study. Diabetes Care 28, 668\u2013674, doi: 10.2337\/diacare.28.3.668 (2005).","journal-title":"Diabetes Care"},{"key":"BFsrep27918_CR56","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1093\/ndt\/18.2.318","volume":"18","author":"H Fukuta","year":"2003","unstructured":"Fukuta, H. et al. Prognostic value of heart rate variability in patients with end-stage renal disease on chronic haemodialysis. Nephrol Dial Transplant 18, 318\u2013325, doi: 10.1093\/ndt\/18.2.318 (2003).","journal-title":"Nephrol Dial Transplant"},{"key":"BFsrep27918_CR57","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1093\/ndt\/gfq234","volume":"25","author":"ME Roumelioti","year":"2010","unstructured":"Roumelioti, M. E. et al. Abnormal nocturnal heart rate variability response among chronic kidney disease and dialysis patients during wakefulness and sleep. Nephrol Dial Transplant 25, 3733\u20133741, doi: 10.1093\/ndt\/gfq234 (2010).","journal-title":"Nephrol Dial Transplant"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep27918.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep27918","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep27918.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:17:55Z","timestamp":1672877875000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep27918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,16]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,6,27]]}},"alternative-id":["BFsrep27918"],"URL":"https:\/\/doi.org\/10.1038\/srep27918","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,16]]},"assertion":[{"value":"10 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27918"}}