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Our previous studies have shown that the human cumulus expansion and steroidogenesis can be regulated by GDF-8. However, thus far, the expression profile of GDF-8 in serum and whether the level of serum GDF-8 influences pregnancy results for patients treated with <jats:italic>in vitro<\/jats:italic> fertilization\/intracytoplasmic sperm injection-embryo transfer (IVF\/ICSI-ET) is totally unknown. In this study, we showed that GDF-8 had a dynamic trend during controlled ovarian hyperstimulation (COH) procedure. On human chorionic gonadotropin (hCG) administration day, patients with a GDF-8 level higher than 4.7\u2009ng\/ml had lower progesterone levels and a higher pregnancy rate. From hCG day to oocyte pick-up day, patients with a GDF-8 decrease greater than 1.3\u2009ng\/ml had a higher progesterone increase and a higher pregnancy rate. Importantly, the levels of GDF-8 were negatively correlated with progesterone levels. Our findings provide evidences that GDF-8 plays an important role in ensuring successful pregnancy by regulating progesterone levels.<\/jats:p>","DOI":"10.1038\/srep28036","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T22:07:03Z","timestamp":1466633223000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Serum GDF-8 levels change dynamically during controlled ovarian hyperstimulation in patients undergoing IVF\/ICSI-ET"],"prefix":"10.1038","volume":"6","author":[{"given":"Lanlan","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Pu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"key":"BFsrep28036_CR1","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.fertnstert.2009.02.066","volume":"93","author":"BS Joo","year":"2010","unstructured":"Joo, B. 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