{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:10:28Z","timestamp":1790115028057,"version":"4.0.1"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T00:00:00Z","timestamp":1466985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The secreted glycoprotein Reelin is believed to play critical roles in the pathogenesis of several neuropsychiatric disorders. The highly basic C-terminal region (CTR) of Reelin is necessary for efficient activation of its downstream signaling and the brain structure of knock-in mice that lack the CTR (\u0394C-KI mice) is impaired. Here, we performed a comprehensive behavioral test battery on \u0394C-KI mice, in order to evaluate the effects of partial loss-of-function of Reelin on brain functions. The \u0394C-KI mice were hyperactive and exhibited reduced anxiety-like and social behaviors. The working memory in \u0394C-KI mice was impaired in a T-maze test. There was little difference in spatial reference memory, depression-like behavior, prepulse inhibition, or fear memory between \u0394C-KI and wild-type mice. These results suggest that CTR-dependent Reelin functions are required for some specific normal brain functions and that \u0394C-KI mice recapitulate some aspects of neuropsychiatric disorders, such as schizophrenia, bipolar disorder and autism spectrum disorder.<\/jats:p>","DOI":"10.1038\/srep28636","type":"journal-article","created":{"date-parts":[[2016,6,27]],"date-time":"2016-06-27T09:11:17Z","timestamp":1467018677000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Mice that lack the C-terminal region of Reelin exhibit behavioral abnormalities related to neuropsychiatric disorders"],"prefix":"10.1038","volume":"6","author":[{"given":"Kaori","family":"Sakai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Kohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Miyakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuharu","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,27]]},"reference":[{"key":"BFsrep28636_CR1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/374719a0","volume":"374","author":"G D\u2019Arcangelo","year":"1995","unstructured":"D\u2019Arcangelo, G. et al. A protein related to extracellular matrix proteins deleted in the mouse mutant reeler. Nature 374, 719\u2013723 (1995).","journal-title":"Nature"},{"key":"BFsrep28636_CR2","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.1523\/JNEUROSCI.18-19-07779.1998","volume":"18","author":"S Alcantara","year":"1998","unstructured":"Alcantara, S. et al. Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse. J Neurosci 18, 7779\u20137799 (1998).","journal-title":"J Neurosci"},{"key":"BFsrep28636_CR3","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.arr.2013.01.005","volume":"12","author":"AM Stranahan","year":"2013","unstructured":"Stranahan, A. M., Erion, J. R. & Wosiski-Kuhn, M. Reelin signaling in development, maintenance and plasticity of neural networks. 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