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However, the underlying molecular mechanisms remain ill-defined. Here, we showed that MSC transplantation reduced the activities of NF-\u03baB signaling and decreased microRNA-548e (miR-548e) levels in the joint tissue in CIA-mice, seemingly through activation of transforming growth factor \u03b2 receptor signaling. Bioinformatics analyses revealed that miR-548e inhibited protein translation of the NF-\u03baB inhibitor, I\u03baB, through binding to the 3\u2032-UTR of the I\u03baB mRNA. MSCs co-transplanted with adeno-associated virus (AAV) carrying miR-548e abolished the therapeutic effects of MSCs on CIA. On the other hand, transplantation of AAV carrying antisense of miR-548e (as-miR-548e) partially mimicked the effects of MSC transplantation on CIA. Together, these data suggest that MSC transplantation may alleviate experimental RA partially through suppressing miR-548e-mediated I\u03baB inhibition.<\/jats:p>","DOI":"10.1038\/srep28915","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T10:06:01Z","timestamp":1467194761000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated I\u03baB expression"],"prefix":"10.1038","volume":"6","author":[{"given":"Xin","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yurong","family":"Cen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"BFsrep28915_CR1","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1038\/nrrheum.2014.110","volume":"10","author":"RH Straub","year":"2014","unstructured":"Straub, R. 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