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In the present study we investigated the interference of\n                    <jats:italic>Lactobacillus crispatus<\/jats:italic>\n                    ,\n                    <jats:italic>L. gasseri<\/jats:italic>\n                    and\n                    <jats:italic>L. vaginalis<\/jats:italic>\n                    , known to be dominant species in the vaginal microbiome, with the infection process of\n                    <jats:italic>C. trachomatis<\/jats:italic>\n                    . Lactobacilli exerted a strong inhibitory effect on\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    infectivity mainly through the action of secreted metabolites in a concentration\/pH dependent mode. Short contact times were the most effective in the inhibition, suggesting a protective role of lactobacilli in the early steps of\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    infection. The best anti-\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    profile was shown by\n                    <jats:italic>L. crispatus<\/jats:italic>\n                    species. In order to delineate metabolic profiles related to anti-\n                    <jats:italic>Chlamydia<\/jats:italic>\n                    activity,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    supernatants were analysed by\n                    <jats:sup>1<\/jats:sup>\n                    H-NMR. Production of lactate and acidification of the vaginal environment seemed to be crucial for the activity, in addition to the consumption of the carbonate source represented by glucose. The main conclusion of this study is that high concentrations of\n                    <jats:italic>L. crispatus<\/jats:italic>\n                    inhibit infectivity of\n                    <jats:italic>C. trachomatis in vitro<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1038\/srep29024","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T07:16:35Z","timestamp":1467184595000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Lactobacillus crispatus inhibits the infectivity of Chlamydia trachomatis elementary bodies, in vitro study"],"prefix":"10.1038","volume":"6","author":[{"given":"Paola","family":"Nardini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogers Alberto","family":"\u00d1ahui Palomino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Parolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Laghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Foschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cevenini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Vitali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Marangoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"BFsrep29024_CR1","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1086\/318710","volume":"32","author":"B Larsen","year":"2001","unstructured":"Larsen, B. & Monif, G. 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