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We hypothesized that NT-pro-BNP, in combination with other clinical factors in terms of a novel NT-pro BNP-based score, may provide even better predictive power for in-hospital mortality among patients with HF. A retrospective study enrolled adult patients with hospitalization-requiring HF who fulfilled the predefined criteria during the period from January 2011 to December 2013. We proposed a novel scoring system consisting of several independent predictors including NT-pro-BNP for predicting in-hospital mortality, and then compared the prognosis-predictive power of the novel NT-pro BNP-based score with other prognosis-predictive scores. A total of 269 patients were enrolled in the current study. Factors such as \u201cserum NT-pro-BNP level above 8100\u2009mg\/dl,\u201d \u201cage above 79 years,\u201d \u201cwithout taking angiotensin converting enzyme inhibitors\/angiotensin receptor blocker,\u201d \u201cwithout taking beta-blocker,\u201d \u201cwithout taking loop diuretics,\u201d \u201cwith mechanical ventilator support,\u201d \u201cwith non-invasive ventilator support,\u201d \u201cwith vasopressors use,\u201d and \u201cexperience of cardio-pulmonary resuscitation\u201d were found as independent predictors. A novel NT-pro BNP-based score composed of these risk factors was proposed with excellent predictability for in-hospital mortality. The proposed novel NT-pro BNP-based score was extremely effective in predicting in-hospital mortality in HF patients.<\/jats:p>","DOI":"10.1038\/srep29590","type":"journal-article","created":{"date-parts":[[2016,7,14]],"date-time":"2016-07-14T11:08:38Z","timestamp":1468494518000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["N-terminal pro b-type natriuretic peptide (NT-pro-BNP) \u2013based score can predict in-hospital mortality in patients with heart failure"],"prefix":"10.1038","volume":"6","author":[{"given":"Ya-Ting","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Teng","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tung-Wei","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Yu","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woung-Ru","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chung","family":"Shiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,14]]},"reference":[{"key":"BFsrep29590_CR1","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1136\/heart.83.5.596","volume":"83","author":"JJ McMurray","year":"2000","unstructured":"McMurray, J. 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