{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:42:17Z","timestamp":1791639737192,"version":"4.3.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T00:00:00Z","timestamp":1468886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Emerging evidence demonstrates that the blockade of intracellular Ca<jats:sup>2+<\/jats:sup> signals may protect pancreatic acinar cells against Ca<jats:sup>2+<\/jats:sup> overload, intracellular protease activation, and necrosis. The activation of cannabinoid receptor subtype 2 (CB<jats:sub>2<\/jats:sub>R) prevents acinar cell pathogenesis in animal models of acute pancreatitis. However, whether CB<jats:sub>2<\/jats:sub>Rs modulate intracellular Ca<jats:sup>2+<\/jats:sup> signals in pancreatic acinar cells is largely unknown. We evaluated the roles of CB<jats:sub>2<\/jats:sub>R agonist, GW405833 (GW) in agonist-induced Ca<jats:sup>2+<\/jats:sup> oscillations in pancreatic acinar cells using multiple experimental approaches with acute dissociated pancreatic acinar cells prepared from wild type, CB<jats:sub>1<\/jats:sub>R-knockout (KO), and CB<jats:sub>2<\/jats:sub>R-KO mice. Immunohistochemical labeling revealed that CB<jats:sub>2<\/jats:sub>R protein was expressed in mouse pancreatic acinar cells. Electrophysiological experiments showed that activation of CB<jats:sub>2<\/jats:sub>Rs by GW reduced acetylcholine (ACh)-, but not cholecystokinin (CCK)-induced Ca<jats:sup>2+<\/jats:sup> oscillations in a concentration-dependent manner; this inhibition was prevented by a selective CB<jats:sub>2<\/jats:sub>R antagonist, AM630, or was absent in CB<jats:sub>2<\/jats:sub>R-KO but not CB<jats:sub>1<\/jats:sub>R-KO mice. In addition, GW eliminated L-arginine-induced enhancement of Ca<jats:sup>2+<\/jats:sup> oscillations, pancreatic amylase, and pulmonary myeloperoxidase. Collectively, we provide novel evidence that activation of CB<jats:sub>2<\/jats:sub>Rs eliminates ACh-induced Ca<jats:sup>2+<\/jats:sup> oscillations and L-arginine-induced enhancement of Ca<jats:sup>2+<\/jats:sup> signaling in mouse pancreatic acinar cells, which suggests a potential cellular mechanism of CB<jats:sub>2<\/jats:sub>R-mediated protection in acute pancreatitis.<\/jats:p>","DOI":"10.1038\/srep29757","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T09:25:08Z","timestamp":1468920308000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cannabinoid receptor subtype 2 (CB2R) agonist, GW405833 reduces agonist-induced Ca2+ oscillations in mouse pancreatic acinar cells"],"prefix":"10.1038","volume":"6","author":[{"given":"Zebing","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunkun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald P.","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingrong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengxiong","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuegong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"BFsrep29757_CR1","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1053\/j.gastro.2007.01.055","volume":"132","author":"SJ Pandol","year":"2007","unstructured":"Pandol, S. J., Saluja, A. K., Imrie, C. W. & Banks, P. A. Acute pancreatitis: bench to the bedside. Gastroenterology 132, 1127\u20131151 (2007).","journal-title":"Gastroenterology"},{"key":"BFsrep29757_CR2","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/nrgastro.2014.39","volume":"11","author":"OJ Bakker","year":"2014","unstructured":"Bakker, O. J. et al. Treatment options for acute pancreatitis. Nature reviews. Gastroenterology & hepatology 11, 462\u2013469 (2014).","journal-title":"Nature reviews. Gastroenterology & hepatology"},{"key":"BFsrep29757_CR3","doi-asserted-by":"publisher","first-page":"13186","DOI":"10.1073\/pnas.1300910110","volume":"110","author":"JV Gerasimenko","year":"2013","unstructured":"Gerasimenko, J. V. et al. Ca2+ release-activated Ca2+ channel blockade as a potential tool in antipancreatitis therapy. Proceedings of the National Academy of Sciences of the United States of America 110, 13186\u201313191 (2013).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"BFsrep29757_CR4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/365061a0","volume":"365","author":"S Munro","year":"1993","unstructured":"Munro, S., Thomas, K. L. & Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 365, 61\u201365 (1993).","journal-title":"Nature"},{"key":"BFsrep29757_CR5","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/0006-2952(96)00480-7","volume":"52","author":"NE Kaminski","year":"1996","unstructured":"Kaminski, N. E. Immune regulation by cannabinoid compounds through the inhibition of the cyclic AMP signaling cascade and altered gene expression. Biochemical pharmacology 52, 1133\u20131140 (1996).","journal-title":"Biochemical pharmacology"},{"key":"BFsrep29757_CR6","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/S0006-2952(97)00630-8","volume":"55","author":"AC Herring","year":"1998","unstructured":"Herring, A. C., Koh, W. S. & Kaminski, N. E. Inhibition of the cyclic AMP signaling cascade and nuclear factor binding to CRE and kappaB elements by cannabinol, a minimally CNS-active cannabinoid. Biochemical pharmacology 55, 1013\u20131023 (1998).","journal-title":"Biochemical pharmacology"},{"key":"BFsrep29757_CR7","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.4049\/jimmunol.1102195","volume":"187","author":"S Basu","year":"2011","unstructured":"Basu, S., Ray, A. & Dittel, B. N. Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses. Journal of immunology 187, 5720\u20135732 (2011).","journal-title":"Journal of immunology"},{"key":"BFsrep29757_CR8","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1517\/13543784.16.7.951","volume":"16","author":"Y Cheng","year":"2007","unstructured":"Cheng, Y. & Hitchcock, S. A. Targeting cannabinoid agonists for inflammatory and neuropathic pain. Expert opinion on investigational drugs 16, 951\u2013965 (2007).","journal-title":"Expert opinion on investigational drugs"},{"key":"BFsrep29757_CR9","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/sj.bjp.0707442","volume":"153","author":"RG Pertwee","year":"2008","unstructured":"Pertwee, R. G. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. British journal of pharmacology 153, 199\u2013215 (2008).","journal-title":"British journal of pharmacology"},{"key":"BFsrep29757_CR10","doi-asserted-by":"publisher","first-page":"G181","DOI":"10.1152\/ajpgi.00133.2012","volume":"304","author":"T Michler","year":"2013","unstructured":"Michler, T. et al. Activation of cannabinoid receptor 2 reduces inflammation in acute experimental pancreatitis via intra-acinar activation of p38 and MK2-dependent mechanisms. American journal of physiology. Gastrointestinal and liver physiology 304, G181\u2013G192 (2013).","journal-title":"American journal of physiology. Gastrointestinal and liver physiology"},{"key":"BFsrep29757_CR11","doi-asserted-by":"publisher","first-page":"5780","DOI":"10.1073\/pnas.96.10.5780","volume":"96","author":"A Zimmer","year":"1999","unstructured":"Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. & Bonner, T. I. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America 96, 5780\u20135785 (1999).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"BFsrep29757_CR12","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0014-2999(00)00211-9","volume":"396","author":"NE Buckley","year":"2000","unstructured":"Buckley, N. E. et al. Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. European journal of pharmacology 396, 141\u2013149 (2000).","journal-title":"European journal of pharmacology"},{"key":"BFsrep29757_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0014-5793(96)00646-1","volume":"390","author":"J Wu","year":"1996","unstructured":"Wu, J. et al. Thimerosal modulates the agonist-specific cytosolic Ca2+ oscillatory patterns in single pancreatic acinar cells of mouse. FEBS Lett 390, 149\u2013152 (1996).","journal-title":"FEBS Lett"},{"key":"BFsrep29757_CR14","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1124\/mol.58.6.1368","volume":"58","author":"J Wu","year":"2000","unstructured":"Wu, J. et al. 2-Aminoethoxydiphenyl borate modulates kinetics of intracellular Ca(2+) signals mediated by inositol 1,4,5-trisphosphate-sensitive Ca(2+) stores in single pancreatic acinar cells of mouse. Mol Pharmacol 58, 1368\u20131374 (2000).","journal-title":"Mol Pharmacol"},{"key":"BFsrep29757_CR15","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1038\/aps.2014.94","volume":"35","author":"ZB Huang","year":"2014","unstructured":"Huang, Z. B. et al. Congo red modulates ACh-induced Ca(2+) oscillations in single pancreatic acinar cells of mice. Acta pharmacologica Sinica 35, 1514\u20131520 (2014).","journal-title":"Acta pharmacologica Sinica"},{"key":"BFsrep29757_CR16","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1113\/jphysiol.2008.162743","volume":"587","author":"K Yang","year":"2009","unstructured":"Yang, K. et al. Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons. J Physiol 587, 345\u2013361 (2009).","journal-title":"J Physiol"},{"key":"BFsrep29757_CR17","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1007\/s00424-004-1295-0","volume":"448","author":"J Wu","year":"2004","unstructured":"Wu, J. et al. 2-aminoethoxydiphenyl borate inhibits agonist-induced Ca2+ signals by blocking inositol trisphosphate formation in acutely dissociated mouse pancreatic acinar cells. Pflugers Archiv: European journal of physiology 448, 592\u2013595 (2004).","journal-title":"Pflugers Archiv: European journal of physiology"},{"key":"BFsrep29757_CR18","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/339317a0","volume":"339","author":"M Wakui","year":"1989","unstructured":"Wakui, M., Potter, B. V. & Petersen, O. H. Pulsatile intracellular calcium release does not depend on fluctuations in inositol trisphosphate concentration. Nature 339, 317\u2013320 (1989).","journal-title":"Nature"},{"key":"BFsrep29757_CR19","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/0092-8674(90)90505-9","volume":"63","author":"M Wakui","year":"1990","unstructured":"Wakui, M., Osipchuk, Y. V. & Petersen, O. H. Receptor-activated cytoplasmic Ca2+ spiking mediated by inositol trisphosphate is due to Ca2(+)-induced Ca2+ release. Cell 63, 1025\u20131032 (1990).","journal-title":"Cell"},{"key":"BFsrep29757_CR20","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/j.1460-2075.1990.tb08162.x","volume":"9","author":"YV Osipchuk","year":"1990","unstructured":"Osipchuk, Y. V., Wakui, M., Yule, D. I., Gallacher, D. V. & Petersen, O. H. Cytoplasmic Ca2+ oscillations evoked by receptor stimulation, G-protein activation, internal application of inositol trisphosphate or Ca2+: simultaneous microfluorimetry and Ca2+ dependent Cl- current recording in single pancreatic acinar cells. The EMBO journal 9, 697\u2013704 (1990).","journal-title":"The EMBO journal"},{"key":"BFsrep29757_CR21","doi-asserted-by":"publisher","first-page":"3534","DOI":"10.1073\/pnas.1118167109","volume":"109","author":"FS den Boon","year":"2012","unstructured":"den Boon, F. S. et al. Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors. Proceedings of the National Academy of Sciences of the United States of America 109, 3534\u20133539 (2012).","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"BFsrep29757_CR22","first-page":"1135","volume":"29","author":"J Zhang","year":"2014","unstructured":"Zhang, J. & Rouse, R. L. Histopathology and pathogenesis of caerulein-, duct ligation-, and arginine-induced acute pancreatitis in Sprague-Dawley rats and C57BL6 mice. Histology and histopathology 29, 1135\u20131152 (2014).","journal-title":"Histology and histopathology"},{"key":"BFsrep29757_CR23","doi-asserted-by":"publisher","first-page":"e0117588","DOI":"10.1371\/journal.pone.0117588","volume":"10","author":"B Kui","year":"2015","unstructured":"Kui, B. et al. New insights into the methodology of L-arginine-induced acute pancreatitis. PloS one 10, e0117588 (2015).","journal-title":"PloS one"},{"key":"BFsrep29757_CR24","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.mce.2015.12.002","volume":"422","author":"LT Yu","year":"2016","unstructured":"Yu, L. T. et al. Recombinant Reg3alpha protein protects against experimental acute pancreatitis in mice. Molecular and cellular endocrinology 422, 150\u2013159 (2016).","journal-title":"Molecular and cellular endocrinology"},{"key":"BFsrep29757_CR25","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.phrs.2008.11.002","volume":"59","author":"G Linari","year":"2009","unstructured":"Linari, G. et al. Involvement of cannabinoid CB1- and CB2-receptors in the modulation of exocrine pancreatic secretion. Pharmacological research: the official journal of the Italian Pharmacological Society 59, 207\u2013214 (2009).","journal-title":"Pharmacological research: the official journal of the Italian Pharmacological Society"},{"key":"BFsrep29757_CR26","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1590\/S0100-879X2009000100003","volume":"42","author":"OH Petersen","year":"2009","unstructured":"Petersen, O.H. Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology. Braz J Med Biol Res 42, 9\u201316 (2009).","journal-title":"Braz J Med Biol Res"},{"key":"BFsrep29757_CR27","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2174\/156802608783498014","volume":"8","author":"KS Marriott","year":"2008","unstructured":"Marriott, K. S. & Huffman, J. W. Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. Current topics in medicinal chemistry 8, 187\u2013204 (2008).","journal-title":"Current topics in medicinal chemistry"},{"key":"BFsrep29757_CR28","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.2174\/1381612003399347","volume":"6","author":"JW Huffman","year":"2000","unstructured":"Huffman, J. W. The search for selective ligands for the CB2 receptor. Current pharmaceutical design 6, 1323\u20131337 (2000).","journal-title":"Current pharmaceutical design"},{"key":"BFsrep29757_CR29","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1016\/S0968-0896(99)00219-9","volume":"7","author":"JW Huffman","year":"1999","unstructured":"Huffman, J. W. et al. 3-(1\u2032,1\u2032-Dimethylbutyl)-1-deoxy-delta8-THC and related compounds: synthesis of selective ligands for the CB2 receptor. Bioorganic & medicinal chemistry 7, 2905\u20132914 (1999).","journal-title":"Bioorganic & medicinal chemistry"},{"key":"BFsrep29757_CR30","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/sj.bjp.0705529","volume":"140","author":"C Zoratti","year":"2003","unstructured":"Zoratti, C., Kipmen-Korgun, D., Osibow, K., Malli, R. & Graier, W. F. Anandamide initiates Ca(2+) signaling via CB2 receptor linked to phospholipase C in calf pulmonary endothelial cells. Br J Pharmacol 140, 1351\u20131362 (2003).","journal-title":"Br J Pharmacol"},{"key":"BFsrep29757_CR31","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1242\/jcs.088930","volume":"125","author":"O Kopach","year":"2012","unstructured":"Kopach, O. et al. Cannabinoid receptors in submandibular acinar cells: functional coupling between saliva fluid and electrolytes secretion and Ca2+ signalling. Journal of cell science 125, 1884\u20131895 (2012).","journal-title":"Journal of cell science"},{"key":"BFsrep29757_CR32","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/S0024-3205(01)01242-5","volume":"69","author":"KJ Chou","year":"2001","unstructured":"Chou, K. J. et al. CP55,940 increases intracellular Ca2+ levels in Madin-Darby canine kidney cells. Life sciences 69, 1541\u20131548 (2001).","journal-title":"Life sciences"},{"key":"BFsrep29757_CR33","first-page":"33","volume":"45","author":"CR Jan","year":"2002","unstructured":"Jan, C. R. et al. Novel effect of CP55,940, a CB1\/CB2 cannabinoid receptor agonist, on intracellular free Ca2+ levels in bladder cancer cells. The Chinese journal of physiology 45, 33\u201339 (2002).","journal-title":"The Chinese journal of physiology"},{"key":"BFsrep29757_CR34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.regpep.2007.08.009","volume":"145","author":"M Nakata","year":"2008","unstructured":"Nakata, M. & Yada, T. Cannabinoids inhibit insulin secretion and cytosolic Ca2+ oscillation in islet beta-cells via CB1 receptors. Regulatory peptides 145, 49\u201353 (2008).","journal-title":"Regulatory peptides"},{"key":"BFsrep29757_CR35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ceca.2005.10.005","volume":"39","author":"P Juan-Pico","year":"2006","unstructured":"Juan-Pico, P. et al. Cannabinoid receptors regulate Ca(2+) signals and insulin secretion in pancreatic beta-cell. Cell calcium 39, 155\u2013162 (2006).","journal-title":"Cell calcium"},{"key":"BFsrep29757_CR36","doi-asserted-by":"publisher","first-page":"e63386","DOI":"10.1371\/journal.pone.0063386","volume":"8","author":"Q Li","year":"2013","unstructured":"Li, Q., Cui, N., Du, Y., Ma, H. & Zhang, Y. Anandamide reduces intracellular Ca2+ concentration through suppression of Na+\/Ca2+ exchanger current in rat cardiac myocytes. PloS one 8, e63386 (2013).","journal-title":"PloS one"},{"key":"BFsrep29757_CR37","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1084\/jem.20120242","volume":"209","author":"W Xiong","year":"2012","unstructured":"Xiong, W. et al. Cannabinoids suppress inflammatory and neuropathic pain by targeting alpha3 glycine receptors. The Journal of experimental medicine 209, 1121\u20131134 (2012).","journal-title":"The Journal of experimental medicine"},{"key":"BFsrep29757_CR38","doi-asserted-by":"crossref","first-page":"22436","DOI":"10.1016\/S0021-9258(18)41548-7","volume":"268","author":"R Doi","year":"1993","unstructured":"Doi, R., Chowdhury, P. & Rayford, P. L. Agonist-regulated alteration of the affinity of pancreatic muscarinic cholinergic receptors. The Journal of biological chemistry 268, 22436\u201322443 (1993).","journal-title":"The Journal of biological chemistry"},{"key":"BFsrep29757_CR39","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1749-6632.2012.06559.x","volume":"1266","author":"R Mohle","year":"2012","unstructured":"Mohle, R. & Drost, A. C. G protein-coupled receptor crosstalk and signaling in hematopoietic stem and progenitor cells. Annals of the New York Academy of Sciences 1266, 63\u201367 (2012).","journal-title":"Annals of the New York Academy of Sciences"},{"key":"BFsrep29757_CR40","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1242\/jcs.115.3.455","volume":"115","author":"LM Luttrell","year":"2002","unstructured":"Luttrell, L. M. & Lefkowitz, R. J. The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. Journal of cell science 115, 455\u2013465 (2002).","journal-title":"Journal of cell science"},{"key":"BFsrep29757_CR41","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1076\/ejom.36.2.97.4774","volume":"36","author":"JR Martinez","year":"1998","unstructured":"Martinez, J. R. & Zhang, G. H. Cross-talk in signal transduction pathways of rat submandibular acinar cells. European journal of morphology 36 Suppl, 190\u2013193 (1998).","journal-title":"European journal of morphology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep29757.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep29757","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep29757.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T06:46:12Z","timestamp":1672901172000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep29757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,19]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,7,28]]}},"alternative-id":["BFsrep29757"],"URL":"https:\/\/doi.org\/10.1038\/srep29757","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,19]]},"assertion":[{"value":"8 April 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29757"}}