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Based on published data indicating that MMP-9 is upregulated upon T cell activation and also in the thymus upon the induction of negative selection, we investigated the contribution of MMP-9 into mouse T cell development and differentiation in the thymus. Our data suggest that MMP-9 deficiency does not result in major abnormalities in the development of any conventionally selected or agonist selected subsets and does not interfere with thymocyte apoptosis and clearance, and that MMP-9 expression is not induced in immature T cells at any stage of their thymic development.<\/jats:p>","DOI":"10.1038\/srep29852","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T09:26:18Z","timestamp":1468920378000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Thymocyte development in the absence of matrix metalloproteinase-9\/gelatinase B"],"prefix":"10.1038","volume":"6","author":[{"given":"Natalia V.","family":"Gounko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Martens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghislain","family":"Opdenakker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasily","family":"Rybakin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"BFsrep29852_CR1","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3109\/10409238.2013.770819","volume":"48","author":"J Vandooren","year":"2013","unstructured":"Vandooren, J., Van den Steen, P. 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