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Hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) can be up-regulated by 50% dietary restriction (DR) for 7-day and can block mitochondrial oxidative stress. H<jats:sub>2<\/jats:sub>S production exerts a critical role in yeast, worm and fruit fly models of DR-mediated longevity. In this study, we found that renal aging could be attenuated by 30% DR for 6-month (DR-6M) and life-long (DR-LL), but not for 6-week (DR-6W). The expressions of cystathionine-\u03b3-lyase (CGL) and cystathionine-\u03b2- synthase (CBS) were improved by DR-6M and DR-LL. Endogenous H<jats:sub>2<\/jats:sub>S production shared the same trend with CBS and CGL, while glutathione (GSH) didn\u2019t. When comparing efficiencies of DR for different durations, more evident production of H<jats:sub>2<\/jats:sub>S was found in DR-6M and DR-LL than in DR-6W. Finally the level of oxidative stress was improved by DR-6M and DR-LL rather than by DR-6W. It concluded that aged rats had the ability to produce enough H<jats:sub>2<\/jats:sub>S on 30% DR interventions protecting against renal aging and the effect of DR for long-term were more significant than that of DR for short-term.<\/jats:p>","DOI":"10.1038\/srep30292","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T09:40:15Z","timestamp":1469526015000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Hydrogen sulfide mediates the protection of dietary restriction against renal senescence in aged F344 rats"],"prefix":"10.1038","volume":"6","author":[{"given":"Wen-juan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-yan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-chun","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-yuan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-meng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Bu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-feng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"BFsrep30292_CR1","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1038\/ki.2008.319","volume":"74","author":"XJ Zhou","year":"2008","unstructured":"Zhou, X. 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