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Previous research on associations between <jats:italic>KIAA0319<\/jats:italic> genetic variations and DD has yielded inconsistent results. It is important to establish a more precise estimate of the DD risk associated with these genetic variations. We carried out a meta-analysis of association studies involving <jats:italic>KIAA0319<\/jats:italic> polymorphisms and DD risk. The results of pooled analysis indicated that none of the six investigated markers in or near the <jats:italic>KIAA0319<\/jats:italic> gene are associated with DD. However, a stratified analysis by the study population revealed opposite associations involving <jats:italic>KIAA0319<\/jats:italic> rs4504469 in European and Asian subgroups. The stratified analysis also showed that the <jats:italic>KIAA0319<\/jats:italic> rs9461045 minor allele (T allele) has a protective effect in Asians. This meta-analysis has allowed us to establish the effects of specific <jats:italic>KIAA0319<\/jats:italic> polymorphisms on DD risk with greater precision, as they vary across populations; analyzing one single nucleotide polymorphism at a time could not fully explain the genetic association for DD.<\/jats:p>","DOI":"10.1038\/srep30454","type":"journal-article","created":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T12:14:47Z","timestamp":1469708087000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Opposite Associations between Individual KIAA0319 Polymorphisms and Developmental Dyslexia Risk across Populations: A Stratified Meta-Analysis by the Study Population"],"prefix":"10.1038","volume":"6","author":[{"given":"Shanshan","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingfei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,28]]},"reference":[{"key":"BFsrep30454_CR1","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/S0140-6736(12)60198-6","volume":"379","author":"RL Peterson","year":"2012","unstructured":"Peterson, R. 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