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We investigated the association of common carotid artery intima-media thickness (CCA-IMT) with snoring sounds in OSA patients. A total of 30 newly diagnosed OSA patients with no history of cardiovascular diseases were prospectively enrolled for measuring mean CCA-IMT with B-mode ultrasonography, body mass index, metabolic syndrome, 10-year cardiovascular disease risk score, high-sensitivity C-reactive protein, and homocysteine. Good-quality signals of full-night snoring sounds in an ordinary sleep condition obtained from 15 participants were further acoustically analyzed (Included group). All variables of interest were not significantly different (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05) between the included and non-included groups except for diastolic blood pressure (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.037). In the included group, CCA-IMT was significantly correlated with snoring sound energies of 0\u201320\u2009Hz (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.608,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.036) and 652\u20131500\u2009Hz (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.632,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.027) and was not significantly associated with that of 20\u2013652\u2009Hz (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.366,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.242) after adjustment for age and sex. Our findings suggest that underlying snoring sounds may cause carotid wall thickening and support the large-scale evaluation of snoring sound characters as markers of surveillance and for risk stratification at diagnosis.\n                  <\/jats:p>","DOI":"10.1038\/srep30559","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T05:14:28Z","timestamp":1469769268000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The Frequency and Energy of Snoring Sounds Are Associated with Common Carotid Artery Intima-Media Thickness in Obstructive Sleep Apnea Patients"],"prefix":"10.1038","volume":"6","author":[{"given":"Guo-She","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Yung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning-Hung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan-Jen","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Guei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Nuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsueh-Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,29]]},"reference":[{"key":"BFsrep30559_CR1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.pcad.2008.08.002","volume":"51","author":"A Atkeson","year":"2009","unstructured":"Atkeson, A. et al. 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