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Here we explored whether variations within three related-dyslexia genes, namely <jats:italic>KIAA0319<\/jats:italic>, <jats:italic>DCDC2<\/jats:italic>, and <jats:italic>CNTNAP<\/jats:italic>, might affect cortical thickness measures in FTD patients. 112 FTD patients underwent clinical and neuropsychological examination, genetic analyses and brain Magnetic Resonance Imaging (MRI). <jats:italic>KIAA0319<\/jats:italic> rs17243157 G\/A, <jats:italic>DCDC2<\/jats:italic> rs793842 A\/G and <jats:italic>CNTNAP2<\/jats:italic> rs17236239 A\/G genetic variations were assessed. Cortical thickness was analysed by Freesurfer. Patients carrying <jats:italic>KIAA0319<\/jats:italic> A*(AG or AA) carriers showed greater cortical thickness atrophy in the left fusiform and inferior temporal gyri, compared to <jats:italic>KIAA0319<\/jats:italic> GG (p\u2009\u2264\u20090.001). Patients carrying <jats:italic>CNTNAP2 G<\/jats:italic>*(<jats:italic>GA or GG<\/jats:italic>) showed reduced cortical thickness in the left insula then<jats:italic>CNTNAP2<\/jats:italic> AA carriers (p\u22640.001). When patients with both <jats:italic>at-risk<\/jats:italic> polymorphisms were considered (<jats:italic>KIAA0319<\/jats:italic> A* and <jats:italic>CNTNAP<\/jats:italic>2 G*), greater and addictive cortical thickness atrophy of the left insula and the inferior temporal gyrus was demonstrated (p\u2009\u2264\u20090.001). No significant effect of <jats:italic>DCDC2<\/jats:italic> was found. In FTD, variations of <jats:italic>KIAA0319<\/jats:italic> and <jats:italic>CNTNAP2<\/jats:italic> genes were related to cortical thickness abnormalities in those brain areas involved in language abilities. These findings shed light on genetic predisposition in defining phenotypic variability in FTD.<\/jats:p>","DOI":"10.1038\/srep30848","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T09:33:54Z","timestamp":1470216834000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Frontotemporal dementia and language networks: cortical thickness reduction is driven by dyslexia susceptibility genes"],"prefix":"10.1038","volume":"6","author":[{"given":"Donata","family":"Paternic\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Manes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Premi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Cosseddu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gazzina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Alberici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Archetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bonomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Sofia","family":"Cotelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cotelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella","family":"Turla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Micheli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Gasparotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"BFsrep30848_CR1","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","volume":"51","author":"D Neary","year":"1998","unstructured":"Neary, D. et al. 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