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Ten SNPs among the\n                    <jats:italic>FGF<\/jats:italic>\n                    and\n                    <jats:italic>FGFR<\/jats:italic>\n                    genes were selected and their associations with NSOC susceptibility were investigated in a case-control study of 602 patients with NSOC and 605 healthy controls.\n                    <jats:italic>FGF2<\/jats:italic>\n                    \/rs1048201,\n                    <jats:italic>FGF5<\/jats:italic>\n                    \/rs3733336 and\n                    <jats:italic>FGF9<\/jats:italic>\n                    \/rs546782 showed suggestive association with NSOC susceptibility. In the combination analysis, the observed odds ratios (ORs) decreased with the number of protective alleles (rs1048201-T, rs3733336-G and rs546782-T) but were not statistically significant beyond the first comparison. Hsa-miRNA-496, hsa-miRNA-145 and hsa-miRNA-187 were predicted to be miRNAs with binding sites within\/near these SNPs and were expressed in lip tissues. Decreased\n                    <jats:italic>FGF2<\/jats:italic>\n                    ,\n                    <jats:italic>FGF5<\/jats:italic>\n                    and\n                    <jats:italic>FGF9<\/jats:italic>\n                    expression was observed in three cell lines transfected with the corresponding miRNAs. Moreover, the three SNPs could contribute to differential binding efficacy between hsa-miRNA-496 and\n                    <jats:italic>FGF2<\/jats:italic>\n                    , hsa-miRNA-145 and\n                    <jats:italic>FGF5<\/jats:italic>\n                    , hsa-miRNA-187 and\n                    <jats:italic>FGF9<\/jats:italic>\n                    in luciferase assay. The results suggest that\n                    <jats:italic>FGF2<\/jats:italic>\n                    \/rs1048201,\n                    <jats:italic>FGF5<\/jats:italic>\n                    \/rs3733336 and\n                    <jats:italic>FGF9<\/jats:italic>\n                    \/rs546782 are associated with the risk of NSOC and that these miRNA-\n                    <jats:italic>FGF<\/jats:italic>\n                    interactions may affect NSOC development.\n                  <\/jats:p>","DOI":"10.1038\/srep31054","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T05:33:48Z","timestamp":1470893628000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Associations between microRNA binding site SNPs in FGFs and FGFRs and the risk of non-syndromic orofacial cleft"],"prefix":"10.1038","volume":"6","author":[{"given":"Dandan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhendong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"BFsrep31054_CR1","doi-asserted-by":"publisher","first-page":"6414","DOI":"10.1038\/ncomms7414","volume":"6","author":"Y Sun","year":"2015","unstructured":"Sun, Y. et al. 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