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The aim of this exploratory study was to evaluate whether there are associations between <jats:italic>TLR7<\/jats:italic> rs179008, <jats:italic>TLR8<\/jats:italic> rs2407992, <jats:italic>TLR9<\/jats:italic> rs187084 or <jats:italic>TLR10<\/jats:italic> rs4129009 polymorphisms and viral findings, clinical characteristics or subsequent wheezing in infants with bronchiolitis. In all, 135 full-term infants were hospitalized for bronchiolitis at age less than 6 months: 129 of them were followed-up until the age of 1.5 years. The outcome measures were repeated wheezing, use of inhaled corticosteroids, atopic dermatitis during the first 1.5 years of life and total serum immunoglobulin E (IgE). There were no significant associations between the genotypes or allele frequencies of <jats:italic>TLR7<\/jats:italic> rs179008, <jats:italic>TLR8<\/jats:italic> rs2407992, <jats:italic>TLR9<\/jats:italic> rs187084 or <jats:italic>TLR10<\/jats:italic> rs4129009 polymorphisms and clinical characteristics or the severity of bronchiolitis during hospitalization. During follow-up, repeated wheezing was more common in children with <jats:italic>TLR9<\/jats:italic> rs187084 variant genotype CC (30.5%) than in children with <jats:italic>TLR9<\/jats:italic> wild-type genotype TT (12.2%) (p\u2009=\u20090.02, aOR 2.73, 95% CI 1.02\u20137.29). The <jats:italic>TLR10<\/jats:italic> rs4129009 minor allele G was associated with elevated total serum IgE. <jats:italic>TLR9<\/jats:italic> rs187084 gene polymorphism may be associated with post-bronchiolitis wheezing and <jats:italic>TLR10<\/jats:italic> rs4129009 gene polymorphism may be associated with atopy.<\/jats:p>","DOI":"10.1038\/srep31165","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T09:34:18Z","timestamp":1470648858000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Post-bronchiolitis wheezing is associated with toll-like receptor 9 rs187084 gene polymorphism"],"prefix":"10.1038","volume":"6","author":[{"given":"Kirsi","family":"Nuolivirta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"T\u00f6rm\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Ter\u00e4sj\u00e4rvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juho","family":"Vuononvirta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petri","family":"Koponen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merja","family":"Helminen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Peltola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"BFsrep31165_CR1","doi-asserted-by":"crossref","unstructured":"AAP. 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