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Owing to its central role, DNA replication machinery has emerged as a prime target for the development of antimicrobial drugs. Here, we report 2\u00c5 structure of \u03b2-clamp from <jats:italic>H. pylori<\/jats:italic> (Hp\u03b2-clamp), which is one of the critical components of DNA polymerase III. Despite of similarity in the overall fold of eubacterial \u03b2-clamp structures, some distinct features in DNA interacting loops exists that have not been reported previously. The <jats:italic>in silico<\/jats:italic> prediction identified the potential binders of \u03b2-clamp such as alpha subunit of DNA pol III and DNA ligase with identification of \u03b2-clamp binding regions in them and validated by SPR studies. Hp\u03b2-clamp interacts with DNA ligase in micromolar binding affinity. Moreover, we have successfully determined the co-crystal structure of \u03b2-clamp with peptide from DNA ligase (not reported earlier in prokaryotes) revealing the region from ligase that interacts with \u03b2-clamp.<\/jats:p>","DOI":"10.1038\/srep31181","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T09:13:41Z","timestamp":1470647621000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Structural insight into \u03b2-Clamp and its interaction with DNA Ligase in Helicobacter pylori"],"prefix":"10.1038","volume":"6","author":[{"given":"Preeti","family":"Pandey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaja Faisal","family":"Tarique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Arif Abdul","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilima","family":"kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samudrala","family":"Gourinath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"BFsrep31181_CR1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.chembiol.2014.02.009S1074-5521(14)00067-2","volume":"21","author":"Z Yin","year":"2014","unstructured":"Yin, Z. et al. 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