{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:08:16Z","timestamp":1777270096158,"version":"3.51.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T00:00:00Z","timestamp":1470182400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T00:00:00Z","timestamp":1470182400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study is to evaluate the visual outcome and identify its crucial related factors in children undergoing cataract surgery for bilateral total congenital cataract (CC). This prospective study included consecutive bilateral total cataract patients undergoing primary surgery at Zhongshan Ophthalmic Center (ZOC), Guangzhou, China from Jan 2010 to May 2014. Visual outcome was estimated by best-corrected visual acuity (BCVA) at last follow-up. Potential related factors, including gender, age at last follow-up, age at primary surgery, surgical procedure, postoperative complications (PCs), frequency of follow-up and changes in spectacles were evaluated. Eighty-eight children (176 eyes) were included in the cohort. The mean post-operative BCVA (logMAR) was 1.07\u2009\u00b1\u20090.53 at the mean follow-up duration 31.07\u2009\u00b1\u200919.36 months. Multivariable generalized estimating equations (GEEs) showed BCVA was significantly associated with PCs, age at last follow-up and age at primary surgery. Partial correlation analysis indicated age at primary surgery was positively correlated with BCVA controlling for the other factors, both for the whole age range (R\u2009=\u20090.415, P\u2009&lt;\u20090.001) and age &gt;6 months (R\u2009=\u20090.867, P\u2009&lt;\u20090.001). Better visual acuity was related to early primary surgery and low PC occurrence in children with bilateral total CC. Timely surgical intervention and strict control of PCs would be potential steps to achieving better visual outcome.<\/jats:p>","DOI":"10.1038\/srep31307","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T09:09:21Z","timestamp":1470215361000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Visual Outcome and Related Factors in Bilateral Total Congenital Cataract Patients: A Prospective Cohort Study"],"prefix":"10.1038","volume":"6","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duoru","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erping","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenzhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianzhong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixia","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinchao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuhua","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haotian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weirong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yizhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,8,3]]},"reference":[{"key":"BFsrep31307_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.2188\/jea.JE20110063","volume":"22","author":"LH Pi","year":"2012","unstructured":"Pi, L. H. et al. Prevalence of eye diseases and causes of visual impairment in school-aged children in Western China. J Epidemiol 22, 37\u201344 (2012).","journal-title":"J Epidemiol"},{"key":"BFsrep31307_CR2","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S0886-3350(97)80040-5","volume":"23","author":"A Foster","year":"1997","unstructured":"Foster, A., Gilbert, C. & Rahi, J. Epidemiology of cataract in childhood: a global perspective. Journal of cataract and refractive surgery 23 Suppl 1, 601\u2013604 (1997).","journal-title":"Journal of cataract and refractive surgery"},{"key":"BFsrep31307_CR3","doi-asserted-by":"publisher","first-page":"e0134864","DOI":"10.1371\/journal.pone.0134864","volume":"10","author":"X Rong","year":"2015","unstructured":"Rong, X., Ji, Y., Fang, Y., Jiang, Y. & Lu, Y. Long-Term Visual Outcomes of Secondary Intraocular Lens Implantation in Children with Congenital Cataracts. PloS one 10, e0134864, doi: 10.1371\/journal.pone.0134864 (2015).","journal-title":"PloS one"},{"key":"BFsrep31307_CR4","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1136\/bjo.85.5.540","volume":"85","author":"L Cassidy","year":"2001","unstructured":"Cassidy, L., Rahi, J., Nischal, K., Russell-Eggitt, I. & Taylor, D. Outcome of lens aspiration and intraocular lens implantation in children aged 5 years and under. The British journal of ophthalmology 85, 540\u2013542 (2001).","journal-title":"The British journal of ophthalmology"},{"key":"BFsrep31307_CR5","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1016\/S0161-6420(97)30033-5","volume":"104","author":"HV Gimbel","year":"1997","unstructured":"Gimbel, H. V., Basti, S., Ferensowicz, M. & DeBroff, B. M. Results of bilateral cataract extraction with posterior chamber intraocular lens implantation in children. Ophthalmology 104, 1737\u20131743 (1997).","journal-title":"Ophthalmology"},{"key":"BFsrep31307_CR6","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/S0161-6420(00)00141-X","volume":"107","author":"MW Peterseim","year":"2000","unstructured":"Peterseim, M. W. & Wilson, M. E. Bilateral intraocular lens implantation in the pediatric population. Ophthalmology 107, 1261\u20131266 (2000).","journal-title":"Ophthalmology"},{"key":"BFsrep31307_CR7","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.ajo.2004.06.068","volume":"138","author":"AR Vasavada","year":"2004","unstructured":"Vasavada, A. R., Raj, S. M. & Nihalani, B. Rate of axial growth after congenital cataract surgery. American journal of ophthalmology 138, 915\u2013924, doi: 10.1016\/j.ajo.2004.06.068 (2004).","journal-title":"American journal of ophthalmology"},{"key":"BFsrep31307_CR8","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1016\/S0886-3350(03)00220-7","volume":"29","author":"ME Wilson Jr.","year":"2003","unstructured":"Wilson, M. E. Jr., Bartholomew, L. R. & Trivedi, R. H. Pediatric cataract surgery and intraocular lens implantation: practice styles and preferences of the 2001 ASCRS and AAPOS memberships. Journal of cataract and refractive surgery 29, 1811\u20131820 (2003).","journal-title":"Journal of cataract and refractive surgery"},{"key":"BFsrep31307_CR9","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1001\/jamaophthalmol.2014.1042","volume":"132","author":"A Mataftsi","year":"2014","unstructured":"Mataftsi, A. et al. Postoperative glaucoma following infantile cataract surgery: an individual patient data meta-analysis. JAMA ophthalmology 132, 1059\u20131067, doi: 10.1001\/jamaophthalmol.2014.1042 (2014).","journal-title":"JAMA ophthalmology"},{"key":"BFsrep31307_CR10","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.jaapos.2011.12.158","volume":"16","author":"Z Lim","year":"2012","unstructured":"Lim, Z., Rubab, S., Chan, Y. H. & Levin, A. V. Management and outcomes of cataract in children: the Toronto experience. J AAPOS 16, 249\u2013254, doi: 10.1016\/j.jaapos.2011.12.158 (2012).","journal-title":"J AAPOS"},{"key":"BFsrep31307_CR11","doi-asserted-by":"publisher","first-page":"77","DOI":"10.2147\/OPTH.S59009","volume":"9","author":"A Medsinge","year":"2015","unstructured":"Medsinge, A. & Nischal, K. K. Pediatric cataract: challenges and future directions. Clin Ophthalmol 9, 77\u201390, doi: 10.2147\/OPTH.S59009 (2015).","journal-title":"Clin Ophthalmol"},{"key":"BFsrep31307_CR12","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1016\/j.ophtha.2007.01.030","volume":"114","author":"RJ Bowman","year":"2007","unstructured":"Bowman, R. J., Kabiru, J., Negretti, G. & Wood, M. L. Outcomes of bilateral cataract surgery in Tanzanian children. Ophthalmology 114, 2287\u20132292, doi: 10.1016\/j.ophtha.2007.01.030 (2007).","journal-title":"Ophthalmology"},{"key":"BFsrep31307_CR13","doi-asserted-by":"publisher","first-page":"4262","DOI":"10.1167\/iovs.05-1160","volume":"47","author":"M Chak","year":"2006","unstructured":"Chak, M., Wade, A. & Rahi, J. S. Long-term visual acuity and its predictors after surgery for congenital cataract: findings of the British congenital cataract study. Investigative ophthalmology & visual science 47, 4262\u20134269, doi: 10.1167\/iovs.05-1160 (2006).","journal-title":"Investigative ophthalmology & visual science"},{"key":"BFsrep31307_CR14","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.ophtha.2015.01.013","volume":"122","author":"GS Negretti","year":"2015","unstructured":"Negretti, G. S. et al. Cataract surgery outcomes in bangladeshi children. Ophthalmology 122, 882\u2013887, doi: 10.1016\/j.ophtha.2015.01.013 (2015).","journal-title":"Ophthalmology"},{"key":"BFsrep31307_CR15","doi-asserted-by":"publisher","first-page":"186","DOI":"10.4103\/0301-4738.128630","volume":"62","author":"PM Gogate","year":"2014","unstructured":"Gogate, P. M. et al. Long term outcomes of bilateral congenital and developmental cataracts operated in Maharashtra, India. Miraj pediatric cataract study III. Indian journal of ophthalmology 62, 186\u2013195, doi: 10.4103\/0301-4738.128630 (2014).","journal-title":"Indian journal of ophthalmology"},{"key":"BFsrep31307_CR16","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/eye.2015.211","volume":"30","author":"P Gogate","year":"2016","unstructured":"Gogate, P. et al. Surgery for sight: outcomes of congenital and developmental cataracts operated in Durban, South Africa. Eye (London, England) 30, 406\u2013412, doi: 10.1038\/eye.2015.211 (2016).","journal-title":"Eye (London, England)"},{"key":"BFsrep31307_CR17","first-page":"227","volume":"79","author":"C Gilbert","year":"2001","unstructured":"Gilbert, C. & Foster, A. Childhood blindness in the context of VISION 2020\u2013the right to sight. Bull World Health Organ 79, 227\u2013232 (2001).","journal-title":"Bull World Health Organ"},{"key":"BFsrep31307_CR18","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1136\/bjo.85.3.267","volume":"85","author":"D Yorston","year":"2001","unstructured":"Yorston, D., Wood, M. & Foster, A. Results of cataract surgery in young children in east Africa. The British journal of ophthalmology 85, 267\u2013271 (2001).","journal-title":"The British journal of ophthalmology"},{"key":"BFsrep31307_CR19","doi-asserted-by":"crossref","unstructured":"Solebo, A. L., Russell-Eggitt, I., Cumberland, P. M. & Rahi, J. S. Risks and outcomes associated with primary intraocular lens implantation in children under 2 years of age: the IoLunder2 cohort study. The British journal of ophthalmology, doi: 10.1136\/bjophthalmol-2014-306394 (2015).","DOI":"10.1016\/S0140-6736(14)62201-7"},{"key":"BFsrep31307_CR20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.4103\/0301-4738.107194","volume":"61","author":"RC Khanna","year":"2013","unstructured":"Khanna, R. C., Foster, A., Krishnaiah, S., Mehta, M. K. & Gogate, P. M. Visual outcomes of bilateral congenital and developmental cataracts in young children in south India and causes of poor outcome. Indian journal of ophthalmology 61, 65\u201370, doi: 10.4103\/0301-4738.107194 (2013).","journal-title":"Indian journal of ophthalmology"},{"key":"BFsrep31307_CR21","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1016\/j.jcrs.2007.06.025","volume":"33","author":"NG Congdon","year":"2007","unstructured":"Congdon, N. G., Ruiz, S., Suzuki, M. & Herrera, V. Determinants of pediatric cataract program outcomes and follow-up in a large series in Mexico. Journal of cataract and refractive surgery 33, 1775\u20131780, doi: 10.1016\/j.jcrs.2007.06.025 (2007).","journal-title":"Journal of cataract and refractive surgery"},{"key":"BFsrep31307_CR22","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1016\/j.jcrs.2003.12.047","volume":"30","author":"J Thakur","year":"2004","unstructured":"Thakur, J. et al. Pediatric cataract surgery in Nepal. Journal of cataract and refractive surgery 30, 1629\u20131635, doi: 10.1016\/j.jcrs.2003.12.047 (2004).","journal-title":"Journal of cataract and refractive surgery"},{"key":"BFsrep31307_CR23","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/eye.2013.168","volume":"27","author":"A Medsinge","year":"2013","unstructured":"Medsinge, A. & Nischal, K. K. Capsular blockage syndrome in a child: a case report. Eye (London, England) 27, 1333\u20131334, doi: 10.1038\/eye.2013.168 (2013).","journal-title":"Eye (London, England)"},{"key":"BFsrep31307_CR24","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1016\/S0161-6420(95)30906-2","volume":"102","author":"JE Egbert","year":"1995","unstructured":"Egbert, J. E. et al. A prospective study of ocular hypertension and glaucoma after pediatric cataract surgery. Ophthalmology 102, 1098\u20131101 (1995).","journal-title":"Ophthalmology"},{"key":"BFsrep31307_CR25","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/S0886-3350(97)80052-1","volume":"23","author":"KM Brady","year":"1997","unstructured":"Brady, K. M., Atkinson, C. S., Kilty, L. A. & Hiles, D. A. Glaucoma after cataract extraction and posterior chamber lens implantation in children. Journal of cataract and refractive surgery 23 Suppl 1, 669\u2013674 (1997).","journal-title":"Journal of cataract and refractive surgery"},{"key":"BFsrep31307_CR26","doi-asserted-by":"publisher","first-page":"414","DOI":"10.3109\/08820538.2014.959192","volume":"29","author":"MC Whitman","year":"2014","unstructured":"Whitman, M. C. & Vanderveen, D. K. Complications of pediatric cataract surgery. Semin Ophthalmol 29, 414\u2013420, doi: 10.3109\/08820538.2014.959192 (2014).","journal-title":"Semin Ophthalmol"},{"key":"BFsrep31307_CR27","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1136\/bjo.76.6.327","volume":"76","author":"JS Elston","year":"1992","unstructured":"Elston, J. S. & Timms, C. Clinical evidence for the onset of the sensitive period in infancy. The British journal of ophthalmology 76, 327\u2013328 (1992).","journal-title":"The British journal of ophthalmology"},{"key":"BFsrep31307_CR28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3928\/0191-3913-20020301-04","volume":"39","author":"SE Olitsky","year":"2002","unstructured":"Olitsky, S. E., Nelson, B. A. & Brooks, S. The sensitive period of visual development in humans. J Pediatr Ophthalmol Strabismus 39, 69\u201372, quiz 105\u2013106 (2002).","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"BFsrep31307_CR29","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1167\/iovs.14-15464","volume":"56","author":"EE Hartmann","year":"2015","unstructured":"Hartmann, E. E., Lynn, M. J. & Lambert, S. R. Baseline characteristics of the infant aphakia treatment study population: predicting recognition acuity at 4.5 years of age. Investigative ophthalmology & visual science 56, 388\u2013395, doi: 10.1167\/iovs.14-15464 (2015).","journal-title":"Investigative ophthalmology & visual science"},{"key":"BFsrep31307_CR30","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3928\/0191-3913-19941101-03","volume":"31","author":"MD Mills","year":"1994","unstructured":"Mills, M. D. & Robb, R. M. Glaucoma following childhood cataract surgery. J Pediatr Ophthalmol Strabismus 31, 355\u2013360; discussion 361 (1994).","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"BFsrep31307_CR31","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/S1091-8531(99)70043-1","volume":"3","author":"SR Lambert","year":"1999","unstructured":"Lambert, S. R., Buckley, E. G., Plager, D. A., Medow, N. B. & Wilson, M. E. Unilateral intraocular lens implantation during the first six months of life. J aapos 3, 344\u2013349 (1999).","journal-title":"J aapos"},{"key":"BFsrep31307_CR32","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/APO.0000000000000082","volume":"4","author":"AH Hussain","year":"2015","unstructured":"Hussain, A. H., Hossain, A., Ferdausi, N., Islam, M. Z. & Sen, U. Visual Outcomes of Congenital Cataract Surgery in a Tertiary Public Hospital in Bangladesh. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 4, 263\u2013266, doi: 10.1097\/APO.0000000000000082 (2015).","journal-title":"Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)"},{"key":"BFsrep31307_CR33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jaapos.2008.07.010","volume":"13","author":"EE Birch","year":"2009","unstructured":"Birch, E. E., Cheng, C., Stager, D. R. Jr., Weakley, D. R. Jr. & Stager, D. R. Sr. The critical period for surgical treatment of dense congenital bilateral cataracts. J aapos 13, 67\u201371, doi: 10.1016\/j.jaapos.2008.07.010 (2009).","journal-title":"J aapos"},{"key":"BFsrep31307_CR34","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.1755-3768.2010.01872.x","volume":"90","author":"DH Kim","year":"2012","unstructured":"Kim, D. H., Kim, J. H., Kim, S. J. & Yu, Y. S. Long-term results of bilateral congenital cataract treated with early cataract surgery, aphakic glasses and secondary IOL implantation. Acta Ophthalmol 90, 231\u2013236, doi: 10.1111\/j.1755-3768.2010.01872.x (2012).","journal-title":"Acta Ophthalmol"},{"key":"BFsrep31307_CR35","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.jaapos.2005.07.008","volume":"9","author":"EE Birch","year":"2005","unstructured":"Birch, E. E., Cheng, C., Stager, D. R. Jr. & Felius, J. Visual acuity development after the implantation of unilateral intraocular lenses in infants and young children. J aapos 9, 527\u2013532, doi: 10.1016\/j.jaapos.2005.07.008 (2005).","journal-title":"J aapos"},{"key":"BFsrep31307_CR36","doi-asserted-by":"publisher","first-page":"e101781","DOI":"10.1371\/journal.pone.0101781","volume":"9","author":"H Lin","year":"2014","unstructured":"Lin, H. et al. Congenital cataract: prevalence and surgery age at Zhongshan Ophthalmic Center (ZOC). PloS one 9, e101781, doi: 10.1371\/journal.pone.0101781 (2014).","journal-title":"PloS one"},{"key":"BFsrep31307_CR37","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1016\/j.ophtha.2012.06.046","volume":"119","author":"H Lin","year":"2012","unstructured":"Lin, H. et al. Effectiveness of a short message reminder in increasing compliance with pediatric cataract treatment: a randomized trial. Ophthalmology 119, 2463\u20132470, doi: 10.1016\/j.ophtha.2012.06.046 (2012).","journal-title":"Ophthalmology"},{"key":"BFsrep31307_CR38","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1007\/s00417-013-2327-2","volume":"251","author":"G Borisovsky","year":"2013","unstructured":"Borisovsky, G., Silberberg, G., Wygnanski-Jaffe, T. & Spierer, A. Results of congenital cataract surgery with and without intraocular lens implantation in infants and children. Graefe\u2019s archive for clinical and experimental ophthalmology\u2009=\u2009Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 251, 2205\u20132211, doi: 10.1007\/s00417-013-2327-2 (2013).","journal-title":"Graefe\u2019s archive for clinical and experimental ophthalmology\u2009=\u2009Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"BFsrep31307_CR39","unstructured":"Brown, B. L. & Hendrix, S. B. In Wiley StatsRef: Statistics Reference Online (John Wiley & Sons, Ltd., 2014)."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/srep31307","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep31307.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/srep31307.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T20:30:08Z","timestamp":1672864208000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/srep31307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,3]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,11,14]]}},"alternative-id":["BFsrep31307"],"URL":"https:\/\/doi.org\/10.1038\/srep31307","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,3]]},"assertion":[{"value":"5 January 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31307"}}