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There is only a limited number of effective drugs to combat these NTD. Medicinal plants are a viable source of parasiticides. In this study, we have investigated six of the 19 phytochemicals isolated from two Bhutanese medicinal plants, <jats:italic>Corydalis crispa<\/jats:italic> and <jats:italic>Pleurospermum amabile<\/jats:italic>, for their anthelmintic properties. We used the xWORM technique and Scanning Electron Microscope-based imaging to determine the activity of the compounds. Of the six compounds tested, isomyristicin and bergapten showed significant anthelmintic activity against <jats:italic>Schistosoma mansoni<\/jats:italic> and <jats:italic>Trichuris muris<\/jats:italic> with bergapten being the most efficacious compound one against both parasites (<jats:italic>S. mansoni<\/jats:italic> IC<jats:sub>50<\/jats:sub>\u2009=\u20098.6 \u03bcg\/mL and <jats:italic>T. muris<\/jats:italic> IC<jats:sub>50<\/jats:sub>\u2009=\u200910.6\u2009\u03bcg\/mL) and also against the schistosomulum stage of <jats:italic>S. mansoni<\/jats:italic>. These two compounds induced tegumental damage to <jats:italic>S. mansoni<\/jats:italic> and affected the cuticle, bacillary bands and bacillary glands of <jats:italic>T. muris<\/jats:italic>. The efficacy against multiple phylogenetically distinct parasites and different life stages, especially the schistosomulum where praziquantel is ineffective, makes isomyristicin and bergapten novel scaffolds for broad-spectrum anthelmintic drug development that could be used for the control of helminths infecting humans and animals.<\/jats:p>","DOI":"10.1038\/srep32101","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T09:38:42Z","timestamp":1472549922000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms"],"prefix":"10.1038","volume":"6","author":[{"given":"Phurpa","family":"Wangchuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul R.","family":"Giacomin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Smout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Loukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"BFsrep32101_CR1","unstructured":"WHO. 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