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We therefore explored the link between PFAR and yeast prion [<jats:italic>PSI<\/jats:italic><jats:sup>+<\/jats:sup>] using both PFAR-enriched mutants and site-directed methylation. We demonstrate that PFAR is involved in propagation and <jats:italic>de novo<\/jats:italic> formation of [<jats:italic>PSI<\/jats:italic><jats:sup>+<\/jats:sup>]. PFAR and the yeast heat-shock protein Hsp104 partially compensate each other for [<jats:italic>PSI<\/jats:italic><jats:sup>+<\/jats:sup>] propagation. Our data also provide insight into new functions for the ribosome in basal thermotolerance and heat-shocked protein refolding. PFAR is thus an evolutionarily conserved cell component implicated in the prion life cycle, and we propose that it could be a potential therapeutic target for human protein misfolding diseases.<\/jats:p>","DOI":"10.1038\/srep32117","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T09:30:24Z","timestamp":1474018224000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Protein Folding Activity of the Ribosome is involved in Yeast Prion Propagation"],"prefix":"10.1038","volume":"6","author":[{"given":"Marc","family":"Blondel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavie","family":"Soubigou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Evrard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phu hai","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naushaba","family":"Hasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Ch\u00e9din","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reynald","family":"Gillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Astrid","family":"Contesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Friocourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Stahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Voisset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,9,16]]},"reference":[{"key":"BFsrep32117_CR1","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1534\/genetics.111.137760","volume":"191","author":"SW Liebman","year":"2012","unstructured":"Liebman, S. 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